The Qadhadhfa (also al-Qaddafa, Gaddadfa, Qaddadfa, Gaddafa; Arabic: القذاذفـة) is one of the branches of the Houara tribe, living in the Sirte District in present-day northwestern Libya as one of the greatest and powerful tribes in the country itself. They are now mostly centered at Sabha.
The tribe has supported the idea of Arab unity as an Arab tribe in Libya itself. They are notable for their role in the 1969 coup d'état deposing King Idris of Libya and as the tribe of Muammar Gaddafi. The tribe is one of the most powerful and influential tribes in Libya and its ongoing civil war. The enormous tribe is known for its active presence in Sirte. Their presence caused Sirte to grow and be comparable to Tripoli and Benghazi. Qadhadhfa influence caused Sirte and Sabha to become completely loyal to leader Muammar Gaddafi.
The Qadhadhfa fought for and supported the Great Socialist People's Libyan Arab Jamahiriya and the Green Resistance throughout the Second Libyan Civil War and the Libyan Crisis.  After Gaddafi's death in October 2011, leading members of the Qadhadhfa demanded the return of his body by Misratan fighters for burial by relatives in Sirte.
- Current biography yearbook, Volume 53, H.W. Wilson Company, 1992, p. 457.
- Jean-François Bayart, Global subjects: a political critique of globalization, Polity, 2007, ISBN 978-0-7456-3668-9, p. 56.
- Dirk J. Vandewalle, Libya since 1969: Qadhafi's revolution revisited, Palgrave Macmillan, 2008, ISBN 978-0-230-60765-1, p. 73.
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