The Anglican church, which was consecrated in 1837, is dedicated to St John the Evangelist, and is part of the Diocese of St Asaph. Former vicars include John David Edwards (vicar 1843-1885), whose most famous hymn tune composition is Rhosymedre.
Rhosymedre Halt railway station served the village from 1906 to 1959.
Rhosymedre is the location of the Cefn Mawr district's local football club, Cefn Druids A.F.C. who have been based at 'the Rock' on Rock Road, Rhosymedre since 2010. They currently play in the Welsh Premier League.
- "Rhosymedre". Genuki. 5 May 2004. Retrieved 1 May 2009.
- "The Parish of Rhosymedre". 2007. Retrieved 1 May 2009.
- Griffith, Robert David. "Edwards, John David (1805–1885), cleric and musician". Welsh Biography Online. National Library of Wales. Retrieved 1 May 2009.
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