Small nuclear ribonucleoprotein polypeptide C

SNRPC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VRD, 3CW1, 4PJO
Identifiers
Aliases	SNRPC, U1C, Yhc1, Small nuclear ribonucleoprotein polypeptide C
External IDs	OMIM: 603522; MGI: 109489; HomoloGene: 136764; GeneCards: SNRPC; OMA:SNRPC - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	34,773,857 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	28,070,942 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; left testis; ; right testis; ; right auricle; ; left ventricle; ; mucosa of transverse colon; ; ventricular zone; ; ganglionic eminence; ; muscle of thigh; ; gastrocnemius muscle;
	Top expressed in
	yolk sac; ; ventricular zone; ; embryo; ; morula; ; embryo; ; neural layer of retina; ; muscle of thigh; ; granulocyte; ; blastocyst; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; zinc ion binding; metal ion binding; protein binding; single-stranded RNA binding; nucleic acid binding; U1 snRNA binding; pre-mRNA 5'-splice site binding; U1 snRNP binding; RNA binding; mRNA binding;
Cellular component	Cajal body; prespliceosome; U1 snRNP; nucleus; commitment complex; nucleoplasm; U2-type prespliceosome;
Biological process	spliceosomal snRNP assembly; mRNA 5'-splice site recognition; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	6631
	20630
	ENSG00000124562
	ENSMUSG00000024217
	P09234
	Q62241
	NM_003093
	NM_011432
	NP_003084
	NP_035562
	Wikidata
View/Edit Human	View/Edit Mouse

U1 small nuclear ribonucleoprotein C is a protein that in humans is encoded by the SNRPC gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

Small nuclear ribonucleoprotein polypeptide C has been shown to interact with Ewing sarcoma breakpoint region 1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124562 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024217 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sillekens PT, Beijer RP, Habets WJ, van Venrooij WJ (October 1988). "Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals". Nucleic Acids Res. 16 (17): 8307–8321. doi:10.1093/nar/16.17.8307. PMC 338560. PMID 2971157.
^ Gunnewiek JM, van Aarssen Y, Wassenaar R, Legrain P, van Venrooij WJ, Nelissen RL (February 1996). "Homodimerization of the human U1 snRNP-specific protein C". Nucleic Acids Res. 23 (23): 4864–4871. doi:10.1093/nar/23.23.4864. PMC 307476. PMID 8532530.
^ "Entrez Gene: SNRPC small nuclear ribonucleoprotein polypeptide C".
^ Knoop, L L; Baker S J (August 2000). "The splicing factor U1C represses EWS/FLI-mediated transactivation". J. Biol. Chem. 275 (32). UNITED STATES: 24865–24871. doi:10.1074/jbc.M001661200. ISSN 0021-9258. PMID 10827180. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

v t e RNA-binding protein: Ribonucleoproteins
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200
hnRNP	A0 C L R
Other transcription	Telomerase
Translation	Ribosome
Vault ribonucleoprotein particles	Major vault protein
Other	Signal recognition particle

Interactions

References

Further reading