Sphingosine N-acyltransferase

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sphingosine N-acyltransferase
Identifiers
EC number2.3.1.24
CAS number37257-09-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a sphingosine N-acyltransferase (EC 2.3.1.24) is an enzyme that catalyzes the chemical reaction

acyl-CoA + sphingosine CoA + N-acylsphingosine

Thus, the two substrates of this enzyme are acyl-CoA and sphingosine, whereas its two products are CoA and N-acylsphingosine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:sphingosine N-acyltransferase. Other names in common use include ceramide synthetase, and sphingosine acyltransferase. This enzyme participates in sphingolipid metabolism.

References[edit]

  • Sribney M (December 1966). "Enzymatic synthesis of ceramide". Biochimica et Biophysica Acta. 125 (3): 542–7. doi:10.1016/0005-2760(66)90042-7. PMID 5973195.