|Plasmodium was a Natural sciences good articles nominee, but did not meet the good article criteria at the time. There are suggestions below for improving the article. Once these issues have been addressed, the article can be renominated. Editors may also seek a reassessment of the decision if they believe there was a mistake.|
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Evolution & Mechanism of Mosquito Infection and Transmission
Although the Evolution section of this article mentions how Plasmodium has evolved to infect the human liver and eventually red blood cells, it does not mention the evolutionary aspects and mechanism(s) that Plasmodium utilize to infect mosquitoes. User:Murtha.22 (User talk:Murtha.22)
Evolution - Mosquito Transmission
- The Evolution section of this article states that Plasmodium "survive and infect" mosquitoes. This may seem to imply that Plasmdodium decreases the fitness of mosquitoes. However, the mosquitoes that transmit Plasmdodium do not have a decreased fitness. This result indicates that vector fitness is an important selective agent shaping the evolution of Plasmodium. I have added a sentence and citation to the article. — Preceding unsigned comment added by Murtha.22 (talk • contribs) 03:10, 1 October 2014 (UTC)
couple suggestions to add to the article
- I would like to see more info on the influence of Plasmodium on the human genome. We know that humans and plasmodium have been evolving together for quite a while so, what are the resistance made by he human body to stand the illness? Some research have lead to the increase in Sickle gene in population where malaria is still endemic.
- Another suggestion is to improve the history behind the evolution of the parasite as of: how and when each type of Plasmodium ruled out many human lives.
- A last suggestion is to talk about the multiple attempts and weapons used to eradicate the disease ( malaria) caused by Plasmodium in humans; such as DDT and their effects. — Preceding unsigned comment added by Daouda.1 (talk • contribs) 03:37, 1 October 2014 (UTC)
- The first and third suggestions concern two other topics, Malaria and History of malaria, and would be best dealt with in those places (if not already covered), not in this article. The suggestion about the evolutionary history of the parasite is relevant but will require careful review of the peer-reviewed literature. Please make sure any additions are properly cited with full inline references as if you were writing a formal review paper. Chiswick Chap (talk) 06:12, 15 October 2014 (UTC)
Time for a rewrite?
Hi all! I'm currently going through and re-organizing/re-writing chunks of this article. Large chunks of this seem to be written in dense jargon, and some fairly controversial statements on taxonomy sit unreferenced. I'll try to separate my edits by topic so that if you see me doing something stupid you can easily revert the relevant edits and let me know and we can all chat here! Any thoughts, suggestions, or help are very welcome! Ajpolino (talk) 04:27, 1 June 2016 (UTC)
- I've removed the following text from the Life Cycle section:
The development from the hepatic stages to the erythrocytic stages has been obscure. In 2006 it was shown that the parasite buds off the hepatocytes in merosomes containing hundreds or thousands of merozoites. These merosomes have been subsequently shown to lodge in the pulmonary capillaries and to disintegrate there slowly over 48–72 hours releasing merozoites. Erythrocyte invasion is enhanced when blood flow is slow and the cells are tightly packed: both of these conditions are found in the alveolar capillaries.
- While it is referenced, the two references are primary sources. The two papers were done in rodent-infecting strains (P. berghei in 2006 and P. yoelii in 2007) and there's no indication (that I know of) that these mechanisms are conserved across all Plasmodium species. Perhaps this kind of thing would be more appropriate at those specific articles. But really, it'd probably be best if we find a review covering this kind of thing. It definitely seems too specific for a section on the life cycle of the genus Plasmodium... Happy to talk about it if anyone objects... Ajpolino (talk) 04:45, 1 June 2016 (UTC)
Ok! I tried to trim the tables out of the article that fit better at the list articles (Plasmodium species infecting birds, Plasmodium species infecting reptiles, etc.). This way we won't have to maintain tables at both locations and the tables can still be easily found (they're linked to at each subsection of this article). If anyone has concerns about this, let's talk about it here. Ajpolino (talk) 22:55, 10 July 2016 (UTC)
- Sturm A, Amino R, van de Sand C, et al. (September 2006). "Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids". Science. 313 (5791): 1287–90. doi:10.1126/science.1129720. PMID 16888102.
- Baer K, Klotz C, Kappe SH, Schnieder T, Frevert U (November 2007). "Release of hepatic Plasmodium yoelii merozoites into the pulmonary microvasculature". PLoS Pathog. 3 (11): e171. doi:10.1371/journal.ppat.0030171. PMC . PMID 17997605.