MPPF

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MPPF
MPPF.png
Names
IUPAC name
4-Fluoro-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridyl)benzamide
Identifiers
3D model (JSmol)
ChemSpider
Properties
C25H27FN4O2
Molar mass 434.51 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

MPPF, with the full name 2'-methoxyphenyl-(N-2'-pyridinyl)-p-fluoro-benzamidoethyipiperazine, is a compound that binds to the serotonin-1A receptor. Labeled with fluorine-18 it has been used as a radioligand with positron emission tomography.[1] It has, e.g., been used to examine the difference in neuroreceptor binding in the human brain across sex and age.[2]

See also[edit]

References[edit]

  1. ^ D. Le Bars (May 1998). "High-Yield Radiosynthesis and Preliminary In Vivo Evaluation of p-18FMPPF, a Fluoro Analog of WAY-100635". Nuclear Medicine and Biology. 25 (4): 343&ndash, 350. doi:10.1016/S0969-8051(97)00229-1.
  2. ^ Nicolas Costes; Merlet, I; Ostrowsky, K; Faillenot, I; Lavenne, F; Zimmer, L; Ryvlin, P; Le Bars, D (December 2005). "A18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging". the Journal of Nuclear Medicine. 46 (12): 1980&ndash, 1989. PMID 16330560.