In some traditions, the Lovers represent relationships and choices. Its appearance in a spread indicates some decision about an existing relationship, a temptation of the heart, or a choice of potential partners. Often an aspect of the Querent's life will have to be sacrificed; a bachelor(ette)'s lifestyle may be sacrificed and a relationship gained (or vice versa), or one potential partner may be chosen while another is turned down. Whatever the choice, it should not be made lightly, as the ramifications will be lasting.
The Lovers card, along with the other Tarot cards of the Major Arcana, appears in the 2011 video game, The Binding of Isaac, and its 2014 remake, The Binding of Isaac: Rebirth, where they act as consumable items with varying effects. The Lovers creates healing items for the player.
It also appears on a video game, Persona 4 as an arcana card, where the character Rise Kujikawa is the player's Social Link to The Lovers arcana, displaying friendship.
It also appears in Persona 3 as an arcana card, where the character Yukari Takeba is the player's Social Link to the Lovers arcana, displaying friendship.