Tissue factor pathway inhibitor

TFPI
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DTG, 1ADZ, 1IRH, 1TFX, 4BQD
Identifiers
Aliases	TFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor
External IDs	OMIM: 152310; MGI: 1095418; HomoloGene: 4579; GeneCards: TFPI; OMA:TFPI - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	187,565,760 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	84,307,119 bp
RNA expression pattern
	Top expressed in
	right lung; ; lower lobe of lung; ; visceral pleura; ; upper lobe of lung; ; placenta; ; upper lobe of left lung; ; stromal cell of endometrium; ; liver; ; pericardium; ; right lobe of liver;
	Top expressed in
	gastrula; ; placenta; ; decidua; ; atrioventricular valve; ; vas deferens; ; dermis; ; endocardial cushion; ; endothelial cell of lymphatic vessel; ; efferent ductule; ; belly cord;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	organelle membrane; extracellular region; cell surface; anchored component of membrane; plasma membrane; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle; extracellular space; caveola;
Biological process	hemostasis; blood coagulation, extrinsic pathway; negative regulation of peptidase activity; blood coagulation; response to lipopolysaccharide; response to estradiol; cellular response to lipopolysaccharide; negative regulation of endopeptidase activity; cellular response to interleukin-1; negative regulation of blood coagulation; cellular response to steroid hormone stimulus;
	Sources:Amigo / QuickGO
Orthologs
	7035
	21788
	ENSG00000003436
	ENSMUSG00000027082
	P10646
	O54819
NM_001032281; NM_006287; NM_001318941; NM_001329239; NM_001329240;
	NM_001329241
	NM_001177319; NM_001177320; NM_011576; NM_001355271; NM_001355273
NP_001027452; NP_001305870; NP_001316168; NP_001316169; NP_001316170;
	NP_006278
	NP_001170790; NP_001170791; NP_035706; NP_001342200; NP_001342202
	Wikidata
View/Edit Human	View/Edit Mouse

Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.

Genetics

The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. The gene has not been completely sequenced yet. A similar gene, termed TFPI2, has been identified on chromosome 7q22; in addition to TFPI activity, its product also has retinal pigment epithelial cell growth-promoting properties.

Protein structure

TFPI has a relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal region.

TFPI consists of a highly negatively charged amino-terminus, three tandemly linked Kunitz domains, and a highly positively charged carboxy-terminus. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypsin inhibitor and bovine basic pancreatic trypsin inhibitor.

Interactions

Tissue factor pathway inhibitor has been shown to interact with Factor X.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000003436 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027082 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Broze, G J; Warren L A; Novotny W F; Higuchi D A; Girard J J; Miletich J P (Feb 1988). "The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action". Blood. 71 (2). UNITED STATES: 335–43. ISSN 0006-4971. PMID 3422166. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)