Plasminogen activator inhibitor-2

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SERPINB2
Protein SERPINB2 PDB 1by7.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SERPINB2, HsT1201, PAI, PAI-2, PAI2, PLANH2, serpin family B member 2
External IDs OMIM: 173390 MGI: 97609 HomoloGene: 20571 GeneCards: 5055
RNA expression pattern
PBB GE SERPINB2 204614 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002575
NM_001143818

NM_001174170
NM_011111

RefSeq (protein)

NP_001137290.1
NP_002566.1

NP_001167641.1
NP_035241.1

Location (UCSC) Chr 18: 63.87 – 63.9 Mb Chr 1: 107.51 – 107.54 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Plasminogen activator inhibitor-2 (placental PAI), a serine protease inhibitor of the serpin superfamily, is a coagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60-kDa extracellular glycosylated form and a 43-kDa intracellular form.

Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.

It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosis during pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.

Interactions[edit]

Plasminogen activator inhibitor-2 (SerpinB2) has been reported to bind a series of intracellular and extracellular proteins. Whether SerpinB2's physiological function is inhibition of the extracellular protease urokinase and/or whether SerpinB2 has intracellular activities remains controversial. At least one of SerpinB2's physiological functions may involve regulation of adaptive immunity.[1]

See also[edit]

Further reading[edit]

References[edit]

  1. ^ Schroder WA, Major L, Suhrbier A (2011). "The role of SerpinB2 in immunity". Crit. Rev. Immunol. 31 (1): 15–30. doi:10.1615/critrevimmunol.v31.i1.20. PMID 21395508. 

External links[edit]