Tubulinyl-Tyr carboxypeptidase
| Tubulinyl-Tyr carboxypeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.17.17 | ||||||||
| CAS no. | 73050-23-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Tubulinyl-Tyr carboxypeptidase (EC 3.4.17.17, carboxypeptidase-tubulin, soluble carboxypeptidase, tubulin-tyrosine carboxypeptidase, tubulin carboxypeptidase, tubulinyltyrosine carboxypeptidase, tyrosinotubulin carboxypeptidase, tyrosyltubulin carboxypeptidase, TTCPase, brain I carboxypeptidase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Cleavage of the -Glu--Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr
This enzyme is active at neutral pH.
This activity has been linked to proteins such as AGTPBP1 in human.[4]
References
- ^ Argaraña, C.E.; Barra, H.S.; Caputto, R. (1980). "Tubulinyl-tyrosine carboxypeptidase from chicken brain: properties and partial purification". J. Neurochem. 34: 114–118. doi:10.1111/j.1471-4159.1980.tb04628.x. PMID 7452228.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Kumar, N.; Flavin, M. (1981). "Preferential action of a brain detyrosinolating carboxypeptidase on polymerized tubulin". J. Biol. Chem. 256: 7678–7686. PMID 6114100.
- ^ Arce, C.A.; Barra, H.S. (1983). "Association of tubulinyl-tyrosine carboxypeptidase with microtubules". FEBS Lett. 157: 75–78. doi:10.1016/0014-5793(83)81119-3. PMID 6862022.
- ^ Rodriguez de la Vega, M. (2007). "Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily". The FASEB Journal. 21: 851–65. doi:10.1096/fj.06-7330com. PMID 17244817.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
External links
- Tubulinyl-Tyr+carboxypeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)