The route's western terminus is at US 62 in west Berryville. The route runs east as Oak View Drive, passing the industrial park area of the city. State maintenance ends at a fork in the road with A. L. Carter Street to the north and Oak View Drive continuing south.
This roadway was added to the state highway system between 2001 and 2002. On June 4, 2014 a minute order was passed by the Arkansas State Highway Commission to reroute US 62S along the newly constructed intersection with the parent route.
The route's western terminus is at US 62/US 412 in west Salem. US 62B runs east along Church Street to the town square, where it turns south along Highway 9. The two concurrent routes continue south along Main Street until meeting US 62/US 412, when US 62B terminates and AR 9 continues south.
The U.S. Route 62 Truck route in Lawrenceburg, Anderson County, Kentucky, follows the U.S. Route 127 Bypass from that route's junction with US 62 to the Kentucky Route 44 junction, then it turns east onto KY 44 into downtown Lawrenceburg.
U.S. Route 62 Temporary (US 62T) is a 3.15-mile-long (5.07 km) bypass around the city of Alliance. US 62T, a four-lane highway, begins at US 62 (Atlantic Boulevard NE/State Street) in Stark County. US 62T then has a highway ramp at Beeson Street. Exit ramps provide access from US 62T to Beeson St NE, and then the highway merges onto State Route 225 (SR 225) and ends.
Although the US 62T designation is unsigned, signs on the road read "To West US 62 / To State Route 225 North". The entire route is built to freeway standards with a speed limit of 60 miles per hour (97 km/h).
U.S. Route 62 Business is a through street in Sharon and Hermitage, Pennsylvania. The route was designated in 1958, after the mainline was moved onto the Shenango Valley Freeway (which is not a true freeway, but instead features at-grade intersections). For its first mile, the route is cosigned with other highways, first Pennsylvania Route 718, then Pennsylvania Route 518. Soon afterward, it expands to four-lanes and contains the hub of commercial development for the region.
U.S. Route 62 Business follows Pine Avenue through downtown Niagara Falls, New York, spanning 2.12 miles (3.41 km) between NY 104 at its western terminus and US 62 at its eastern extent. Although it runs in a mostly east–west direction, it is signed as a north–south route due to US 62 being signed north–south as well within New York.
Pine Avenue was originally designated as part of NY 34 in the 1920s. It then became part of NY 18 after it replaced NY 34 in 1930. In 1932, US 62 was extended into New York and overlapped NY 18 between Dayton and Niagara Falls. NY 18 was truncated to Lewiston, a village north of the city, in the early 1960s, making US 62 the sole occupant of Pine Avenue. US 62 was shifted onto its current alignment through the city later in the decade, allowing Pine Avenue to become New York State Route 62A in the 1970s. NY 62A was redesignated as US 62 Business in 2006.
^Highway Map of Arkansas (Map). Cartography by Planning and Research Division. Little Rock, Arkansas: Arkansas State Highway and Transportation Department. 2001. Archived from the original(TIFF) on October 13, 2011. Retrieved December 22, 2011.
^Highway Map of Arkansas(PDF) (Map). Cartography by Planning and Research Division. Little Rock, Arkansas: Arkansas State Highway and Transportation Department. 2002. Archived from the original(PDF) on October 13, 2011. Retrieved December 22, 2011.
^Hall, Ralph (June 7, 2014). "Memorandum"(PDF). Little Rock, AR: AHTD. Retrieved July 12, 2014.
^Highway Map of Arkansas (Map). Cartography by Planning and Research Division. Little Rock, Arkansas: Arkansas State Highway and Transportation Department. 1989. Archived from the original(TIFF) on October 13, 2011. Retrieved December 22, 2011.
^Highway Map of Arkansas(TIFF) (Map). Cartography by Planning and Research Division. Little Rock, Arkansas: Arkansas State Highway and Transportation Department. 1990. Retrieved December 22, 2011.