The 1886 South Carolina United States House of Representatives elections were held on November 2, 1886 to select seven Representatives for two-year terms from the state of South Carolina. Five incumbents were re-elected, the Republican incumbent was defeated, and the open seat was retained by the Democrats. The composition of the state delegation after the election was solely Democratic.
Incumbent Democratic Congressman John J. Hemphill of the 5th congressional district, in office since 1883, won the Democratic primary and was unopposed in the general election.