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{{PBB|geneid=9618}}
{{PBB|geneid=9618}}
'''TNF receptor-associated factor 4''' is a [[protein]] that in humans is encoded by the ''TRAF4'' [[gene]].<ref name="pmid7592751">{{cite journal | author = Regnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC | title = Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma | journal = J Biol Chem | volume = 270 | issue = 43 | pages = 25715–21 | year = 1995 | month = Dec | pmid = 7592751 | pmc = | doi =10.1074/jbc.270.43.25715 }}</ref><ref name="pmid7490069">{{cite journal | author = Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC | title = Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17 | journal = Genomics | volume = 28 | issue = 3 | pages = 367–76 | year = 1996 | month = Jan | pmid = 7490069 | pmc = | doi = 10.1006/geno.1995.1163 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRAF4 TNF receptor-associated factor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9618| accessdate = }}</ref>
'''TNF receptor-associated factor 4''' (TRAF4) also known as '''RING finger protein 83''' (RNF83) is a [[protein]] that in humans is encoded by the ''TRAF4'' [[gene]].<ref name="pmid7592751">{{cite journal | author = Regnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC | title = Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma | journal = J Biol Chem | volume = 270 | issue = 43 | pages = 25715–21 | year = 1995 | month = Dec | pmid = 7592751 | pmc = | doi =10.1074/jbc.270.43.25715 }}</ref><ref name="pmid7490069">{{cite journal | author = Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC | title = Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17 | journal = Genomics | volume = 28 | issue = 3 | pages = 367–76 | year = 1996 | month = Jan | pmid = 7490069 | pmc = | doi = 10.1006/geno.1995.1163 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRAF4 TNF receptor-associated factor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9618| accessdate = }}</ref>


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TRAF4 is a member of the TNF receptor associated factor (TRAF) family, a family of [[scaffold protein]]s.<ref name="pmid11384837">{{cite journal | author = Wajant H, Henkler F, Scheurich P | title = The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators | journal = Cell. Signal. | volume = 13 | issue = 6 | pages = 389–400 | year = 2001 | month = June | pmid = 11384837 | doi = | url = | issn = }}</ref> TRAF proteins connect [[interleukin-1 receptor|IL-1R]]/Toll and [[tumor necrosis factor receptor |TNF receptors]] with signaling factors that lead to the activation of [[NF-κB]] and [[mitogen-activated protein kinase]]s. However, TRAF4 is not known to interact with TNF receptors and its cellular functions are not well understood.<ref name="pmid17633017">{{cite journal | author = Kedinger V, Rio MC | title = TRAF4, the unique family member | journal = Adv. Exp. Med. Biol. | volume = 597 | issue = | pages = 60–71 | year = 2007 | pmid = 17633017 | doi = 10.1007/978-0-387-70630-6_5 | url = | issn = }}</ref>
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{{PBB_Summary
| section_title =
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| summary_text = This gene encodes a member of the TNF receptor associated factor (TRAF) family, a family of [[scaffold protein]]s. <ref> {{cite | author=Wajant et al. |title = The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. |journal = Cell Signal (2001) vol. 13 (6) pp. 389-400.}}</ref> [[TRAF]] proteins connect IL-1R/Toll and TNF receptors with signaling factors that lead to the activation of NF-kß and mitogen-activated protein kinases. However, TRAF4 is not known to interact with TNF receptors and its cellular functions are not well understood.<ref> {{cite | author= Kedinger and Rio. Chapter 5 TRAF4, the Unique Family Member. Advances in experimental medicine and biology (2007) pp. 1-12}}</ref>


==TRAF4 Protein Interactions==
== Protein interactions ==
TRAF4 has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: TRAF4 TNF receptor-associated factor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9618| accessdate = }}</ref>
}}


TRAF4 has been shown to [[Protein-protein_interaction|interact]] with [[Low affinity nerve growth factor receptor]].<ref name=pmid10514511>{{cite journal |last=Ye |first=X |authorlink= |coauthors=Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang J J, Leo E, Zapata J, Hauser C A, Reed J C, Bredesen D E |year=[[1999]]|month=Oct. |title=TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction |journal=J. Biol. Chem. |volume=274 |issue=42 |pages=30202–8 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10514511 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.42.30202 }}</ref><ref name=pmid9626059>{{cite journal |unused_data=DUPLICATE DATA: pmid = 9846990 |last=Krajewska |first=M |authorlink= |coauthors=Krajewski S, Zapata J M, Van Arsdale T, Gascoyne R D, Berern K, McFadden D, Shabaik A, Hugh J, Reynolds A, Clevenger C V, Reed J C |year=[[1998]]|month=Jun. |title=TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues |journal=Am. J. Pathol. |volume=152 |issue=6 |pages=1549–61 |publisher= |location = UNITED STATES| issn = 0002-9440| pmid = 9626059 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1858434 }}</ref>
TRAF4 has been shown to interact with [[nerve growth factor receptor|neurotrophin receptor]], [[low-affinity nerve growth factor receptor|p75]] (NTR/NTSR1),<ref name="pmid10514511">{{cite journal | author = Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE | title = TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction | journal = J. Biol. Chem. | volume = 274 | issue = 42 | pages = 30202–8 | year = 1999 | month = October | pmid = 10514511 | doi = | url = | issn = }}</ref><ref name="pmid9626059">{{cite journal | author = Krajewska M, Krajewski S, Zapata JM, Van Arsdale T, Gascoyne RD, Berern K, McFadden D, Shabaik A, Hugh J, Reynolds A, Clevenger CV, Reed JC | title = TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues | journal = Am. J. Pathol. | volume = 152 | issue = 6 | pages = 1549–61 | year = 1998 | month = June | pmid = 9626059 | pmc = 1858434 | doi = | url = | issn = }}</ref> and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to [[neutrophil cytosolic factor 1|p47phox]], a cytosolic regulatory factor included in a multi-protein complex known as [[NAD(P)H oxidase]]. This protein thus, is thought to be involved in the oxidative activation of [[MAPK8]]/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: TRAF4 TNF receptor-associated factor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9618| accessdate = }}</ref>


==References==
==References==
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{{reflist}}
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==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
{{PBB_Further_reading
| citations =
| citations =
*{{cite journal | author=Wajant H, Henkler F, Scheurich P |title=The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. |journal=Cell. Signal. |volume=13 |issue= 6 |pages= 389–400 |year= 2001 |pmid= 11384837 |doi=10.1016/S0898-6568(01)00160-7 }}
*{{cite journal | author=Bradley JR, Pober JS |title=Tumor necrosis factor receptor-associated factors (TRAFs). |journal=Oncogene |volume=20 |issue= 44 |pages= 6482–91 |year= 2001 |pmid= 11607847 |doi= 10.1038/sj.onc.1204788 }}
*{{cite journal | author=Bradley JR, Pober JS |title=Tumor necrosis factor receptor-associated factors (TRAFs). |journal=Oncogene |volume=20 |issue= 44 |pages= 6482–91 |year= 2001 |pmid= 11607847 |doi= 10.1038/sj.onc.1204788 }}
*{{cite journal | author=Masson R, Régnier CH, Chenard MP, ''et al.'' |title=Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development. |journal=Mech. Dev. |volume=71 |issue= 1-2 |pages= 187–91 |year= 1998 |pmid= 9507120 |doi=10.1016/S0925-4773(97)00192-5 }}
*{{cite journal | author=Masson R, Régnier CH, Chenard MP, ''et al.'' |title=Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development. |journal=Mech. Dev. |volume=71 |issue= 1-2 |pages= 187–91 |year= 1998 |pmid= 9507120 |doi=10.1016/S0925-4773(97)00192-5 }}
*{{cite journal | author=Krajewska M, Krajewski S, Zapata JM, ''et al.'' |title=TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. |journal=Am. J. Pathol. |volume=152 |issue= 6 |pages= 1549–61 |year= 1998 |pmid= 9626059 |doi= | pmc=1858434 }}
*{{cite journal | author=Ye X, Mehlen P, Rabizadeh S, ''et al.'' |title=TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30202–8 |year= 1999 |pmid= 10514511 |doi=10.1074/jbc.274.42.30202 }}
*{{cite journal | author=Zapata JM, Pawlowski K, Haas E, ''et al.'' |title=A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24242–52 |year= 2001 |pmid= 11279055 |doi= 10.1074/jbc.M100354200 }}
*{{cite journal | author=Zapata JM, Pawlowski K, Haas E, ''et al.'' |title=A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24242–52 |year= 2001 |pmid= 11279055 |doi= 10.1074/jbc.M100354200 }}
*{{cite journal | author=Régnier CH, Masson R, Kedinger V, ''et al.'' |title=Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 8 |pages= 5585–90 |year= 2002 |pmid= 11943846 |doi= 10.1073/pnas.052124799 | pmc=122813 }}
*{{cite journal | author=Régnier CH, Masson R, Kedinger V, ''et al.'' |title=Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 8 |pages= 5585–90 |year= 2002 |pmid= 11943846 |doi= 10.1073/pnas.052124799 | pmc=122813 }}

Revision as of 04:12, 29 October 2010

Template:PBB TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.[1][2][3]

TRAF4 is a member of the TNF receptor associated factor (TRAF) family, a family of scaffold proteins.[4] TRAF proteins connect IL-1R/Toll and TNF receptors with signaling factors that lead to the activation of NF-κB and mitogen-activated protein kinases. However, TRAF4 is not known to interact with TNF receptors and its cellular functions are not well understood.[5]

Protein interactions

TRAF4 has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1),[6][7] and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.[3]

References

  1. ^ Regnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC (1995). "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma". J Biol Chem. 270 (43): 25715–21. doi:10.1074/jbc.270.43.25715. PMID 7592751. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  2. ^ Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ a b "Entrez Gene: TRAF4 TNF receptor-associated factor 4".
  4. ^ Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. Signal. 13 (6): 389–400. PMID 11384837. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  5. ^ Kedinger V, Rio MC (2007). "TRAF4, the unique family member". Adv. Exp. Med. Biol. 597: 60–71. doi:10.1007/978-0-387-70630-6_5. PMID 17633017.
  6. ^ Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. PMID 10514511. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  7. ^ Krajewska M, Krajewski S, Zapata JM, Van Arsdale T, Gascoyne RD, Berern K, McFadden D, Shabaik A, Hugh J, Reynolds A, Clevenger CV, Reed JC (1998). "TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues". Am. J. Pathol. 152 (6): 1549–61. PMC 1858434. PMID 9626059. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

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