NS1 antigen test: Difference between revisions
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*{{cite journal|last1=Peeling|first1=Rosanna W.|last2=Artsob|first2=Harvey|last3=Pelegrino|first3=Jose Luis|last4=Buchy|first4=Philippe|last5=Cardosa|first5=Mary J.|last6=Devi|first6=Shamala|last7=Enria|first7=Delia A.|last8=Farrar|first8=Jeremy|last9=Gubler|first9=Duane J.|last10=Guzman|first10=Maria G.|last11=Halstead|first11=Scott B.|last12=Hunsperger|first12=Elizabeth|last13=Kliks|first13=Susie|last14=Margolis|first14=Harold S.|last15=Nathanson|first15=Carl M.|last16=Nguyen|first16=Vinh Chau|last17=Rizzo|first17=Nidia|last18=Vázquez|first18=Susana|last19=Yoksan|first19=Sutee|title=Evaluation of diagnostic tests: dengue|journal=Nature Reviews Microbiology|date=1 December 2010|volume=8|pages=S30–S37|doi=10.1038/nrmicro2459|url=http://www.nature.com/nrmicro/journal/v8/n12_supp/full/nrmicro2459.html|accessdate=26 July 2016|language=en}} |
*{{cite journal|last1=Peeling|first1=Rosanna W.|last2=Artsob|first2=Harvey|last3=Pelegrino|first3=Jose Luis|last4=Buchy|first4=Philippe|last5=Cardosa|first5=Mary J.|last6=Devi|first6=Shamala|last7=Enria|first7=Delia A.|last8=Farrar|first8=Jeremy|last9=Gubler|first9=Duane J.|last10=Guzman|first10=Maria G.|last11=Halstead|first11=Scott B.|last12=Hunsperger|first12=Elizabeth|last13=Kliks|first13=Susie|last14=Margolis|first14=Harold S.|last15=Nathanson|first15=Carl M.|last16=Nguyen|first16=Vinh Chau|last17=Rizzo|first17=Nidia|last18=Vázquez|first18=Susana|last19=Yoksan|first19=Sutee|title=Evaluation of diagnostic tests: dengue|journal=Nature Reviews Microbiology|date=1 December 2010|volume=8|pages=S30–S37|doi=10.1038/nrmicro2459|url=http://www.nature.com/nrmicro/journal/v8/n12_supp/full/nrmicro2459.html|accessdate=26 July 2016|language=en}} |
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*{{cite web|title=The Importance of Accurate Diagnosis of Dengue Fever|url=http://www.medscape.com/viewarticle/756315_2|website=www.medscape.com|publisher=Medscape|accessdate=26 July 2016}} |
*{{cite web|title=The Importance of Accurate Diagnosis of Dengue Fever|url=http://www.medscape.com/viewarticle/756315_2|website=www.medscape.com|publisher=Medscape|accessdate=26 July 2016}} |
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*{{Cite journal | doi = 10.1186/1471-2334-10-142| pmid = 20509940| title = Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses| journal = BMC Infectious Diseases| volume = 10| pages = 142| year = 2010| last1 = Tricou | first1 = V. | last2 = Vu | first2 = H. T. | last3 = Quynh | first3 = N. V. | last4 = Nguyen | first4 = C. V. | last5 = Tran | first5 = H. T. | last6 = Farrar | first6 = J. | last7 = Wills | first7 = B. | last8 = Simmons | first8 = C. P. | pmc = 2895602}} |
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*{{Cite journal|title = Evaluation of Dengue NS1 Antigen Rapid Tests and ELISA Kits Using Clinical Samples|journal = PLoS ONE|date = 2014-11-20|issn = 1932-6203|pmc = 4239072|pmid = 25412170|volume = 9|issue = 11|doi = 10.1371/journal.pone.0113411|first = Subhamoy|last = Pal|first2 = Allison L.|last2 = Dauner|first3 = Indrani|last3 = Mitra|first4 = Brett M.|last4 = Forshey|first5 = Paquita|last5 = Garcia|first6 = Amy C.|last6 = Morrison|first7 = Eric S.|last7 = Halsey|first8 = Tadeusz J.|last8 = Kochel|first9 = Shuenn-Jue L.|last9 = Wu}} |
*{{Cite journal|title = Evaluation of Dengue NS1 Antigen Rapid Tests and ELISA Kits Using Clinical Samples|journal = PLoS ONE|date = 2014-11-20|issn = 1932-6203|pmc = 4239072|pmid = 25412170|volume = 9|issue = 11|doi = 10.1371/journal.pone.0113411|first = Subhamoy|last = Pal|first2 = Allison L.|last2 = Dauner|first3 = Indrani|last3 = Mitra|first4 = Brett M.|last4 = Forshey|first5 = Paquita|last5 = Garcia|first6 = Amy C.|last6 = Morrison|first7 = Eric S.|last7 = Halsey|first8 = Tadeusz J.|last8 = Kochel|first9 = Shuenn-Jue L.|last9 = Wu}} |
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*{{cite journal|last1=Paranavitane|first1=Shiran Ajith|last2=Gomes|first2=Laksiri|last3=Kamaladasa|first3=Achala|last4=Adikari|first4=Thiruni N|last5=Wickramasinghe|first5=Nilanka|last6=Jeewandara|first6=Chandima|last7=Shyamali|first7=Narangoda Liyanage Ajantha|last8=Ogg|first8=Graham Stuart|last9=Malavige|first9=Gathsaurie Neelika|title=Dengue NS1 antigen as a marker of severe clinical disease|journal=BMC Infectious Diseases|date=31 October 2014|volume=14|issue=1|doi=10.1186/s12879-014-0570-8|url=http://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-014-0570-8|accessdate=26 July 2016|language=En|issn=1471-2334}} |
*{{cite journal|last1=Paranavitane|first1=Shiran Ajith|last2=Gomes|first2=Laksiri|last3=Kamaladasa|first3=Achala|last4=Adikari|first4=Thiruni N|last5=Wickramasinghe|first5=Nilanka|last6=Jeewandara|first6=Chandima|last7=Shyamali|first7=Narangoda Liyanage Ajantha|last8=Ogg|first8=Graham Stuart|last9=Malavige|first9=Gathsaurie Neelika|title=Dengue NS1 antigen as a marker of severe clinical disease|journal=BMC Infectious Diseases|date=31 October 2014|volume=14|issue=1|doi=10.1186/s12879-014-0570-8|url=http://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-014-0570-8|accessdate=26 July 2016|language=En|issn=1471-2334}} |
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Revision as of 10:33, 24 September 2018
| NS1 antigen test | |
|---|---|
A-Crystal-Structure-of-the-Dengue-Virus (which causes Dengue fever | |
| ICD-10-PCS | A90 |
| LOINC | 75377-2 |
NS1 antigen test (nonstructural protein 1), is a test for dengue, introduced in 2006. It allows rapid detection on the first day of fever, before antibodies appear some 5 or more days later.[1] It has been adopted for use in some 40 nations. The method of detection is through enzyme-linked immunosorbent assay.[1][2] India has introduced in 2010 the NS1 test costing 1,600 rupees at a private hospital in Mumbai.[2]
Medical use
The medical use of the NS1 antigen test can be defined to diagnose dengue infections and is effective to 1st day detection. Additionally, NS1 assay is useful for differential diagnostics in regards to flaviviruses.[3]
NS1 is present in the serum of infected persons directly at the onset of clinical symptoms in primary dengue infection and produces a strong humoral response. It is detectable before the appearance of IgM antibodies.[4]
DENV by NS1 antigen is laboratory confirmation of dengue in people also assessing clinical aspects (as well as, taking into account where the individual may have traveled recently).[5] Serological tests such as an immunoglobulin M antibody capture–enzyme-linked immunosorbent assay (MAC-ELISA) and viral RNA detection by reverse transcriptase (RT-PCR) can also be used to diagnose Dengue fever.[6]
See also
References
- ^ a b Bio Rad Launches Test for Early Diagnosis of the Dengue Virus
- ^ a b Debroy, Sumitra (September 16, 2010). "Now, get dengue test results in just 48 hours". The Times of India.
- ^ "CDC - Laboratory Guidance - Dengue". www.cdc.gov. Retrieved 2015-12-01.
- ^ Amorim JH, Alves RP, Boscardin SB, Ferreira LC (March 2014). "The dengue virus non-structural 1 protein: risks and benefits". Virus Research. 181: 53–60. doi:10.1016/j.virusres.2014.01.001. PMID 24434336.
- ^ "Dengue - Chapter 3 - 2016 Yellow Book | Travelers' Health | CDC". wwwnc.cdc.gov. Retrieved 2015-12-01.
- ^ Narayan R, Raja S, Kumar S, Sambasivam M, Jagadeesan R, Arunagiri K, Krishnasamy K, Palani G (July 2016). "A novel indirect ELISA for diagnosis of dengue fever". The Indian Journal of Medical Research. 144 (1): 128–133. doi:10.4103/0971-5916.193300. PMC 5116886. PMID 27834337.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
Further reading
- Peeling, Rosanna W.; Artsob, Harvey; Pelegrino, Jose Luis; Buchy, Philippe; Cardosa, Mary J.; Devi, Shamala; Enria, Delia A.; Farrar, Jeremy; Gubler, Duane J.; Guzman, Maria G.; Halstead, Scott B.; Hunsperger, Elizabeth; Kliks, Susie; Margolis, Harold S.; Nathanson, Carl M.; Nguyen, Vinh Chau; Rizzo, Nidia; Vázquez, Susana; Yoksan, Sutee (1 December 2010). "Evaluation of diagnostic tests: dengue". Nature Reviews Microbiology. 8: S30–S37. doi:10.1038/nrmicro2459. Retrieved 26 July 2016.
- "The Importance of Accurate Diagnosis of Dengue Fever". www.medscape.com. Medscape. Retrieved 26 July 2016.
- Tricou, V.; Vu, H. T.; Quynh, N. V.; Nguyen, C. V.; Tran, H. T.; Farrar, J.; Wills, B.; Simmons, C. P. (2010). "Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses". BMC Infectious Diseases. 10: 142. doi:10.1186/1471-2334-10-142. PMC 2895602. PMID 20509940.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Pal, Subhamoy; Dauner, Allison L.; Mitra, Indrani; Forshey, Brett M.; Garcia, Paquita; Morrison, Amy C.; Halsey, Eric S.; Kochel, Tadeusz J.; Wu, Shuenn-Jue L. (2014-11-20). "Evaluation of Dengue NS1 Antigen Rapid Tests and ELISA Kits Using Clinical Samples". PLoS ONE. 9 (11). doi:10.1371/journal.pone.0113411. ISSN 1932-6203. PMC 4239072. PMID 25412170.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Paranavitane, Shiran Ajith; Gomes, Laksiri; Kamaladasa, Achala; Adikari, Thiruni N; Wickramasinghe, Nilanka; Jeewandara, Chandima; Shyamali, Narangoda Liyanage Ajantha; Ogg, Graham Stuart; Malavige, Gathsaurie Neelika (31 October 2014). "Dengue NS1 antigen as a marker of severe clinical disease". BMC Infectious Diseases. 14 (1). doi:10.1186/s12879-014-0570-8. ISSN 1471-2334. Retrieved 26 July 2016.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
