Actinidain

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actinidain
Actinidain 1AEC.png
Cartoon diagram of actinidain from Actinidia chinensis. From PDB 1AEC.
Identifiers
EC number 3.4.22.14
CAS number 39279-27-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Actinidain (EC 3.4.22.14, actinidin, Actinidia anionic protease, proteinase A2 of Actinidia chinensis) is a type of cysteine protease enzyme found in fruits including kiwifruit (genus Actinidia), pineapple, mango, banana and papaya. This enzyme is part of the papain-like peptidase C1 family.[1][2][3] This enzyme catalyses the following chemical reaction

Similar to that of papain.

From the kiwi fruit or Chinese gooseberry (Actinidia chinensis).

It is a known allergen and commercially useful as a meat tenderizer.

References[edit]

  1. ^ Baker, E.N., Boland, M.J., Calder, P.C. and Hardman, M.J. (1980). "The specificity of actinidin and its relationship to the structure of the enzyme". Biochim. Biophys. Acta 616: 30–34. doi:10.1016/0005-2744(80)90260-0. PMID 7002215. 
  2. ^ Kamphuis, I.G., Drenth, J. and Baker, E.N. (1985). "Thiol proteases. Comparative studies based on the high-resolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and H, and stem bromelain". J. Mol. Biol. 182: 317–329. PMID 3889350. 
  3. ^ Baker, E.N. and Drenth, J. (1987). "The thiol proteases: structure and mechanism". In Jurnak, F.A. and McPherson, A. Active Sites of Enzymes. Biological Macromolecules and Assemblies 3. New York: John Wiley and Sons. pp. 314–368. ISBN 0-471-85142-6. 

External links[edit]