On 15 November 2009, Aldo's brother Antonio who played for AE Larissa died from a heart attack at the age of 31. In the first game after his brother's death he dedicated his only goal to him in an Apertura 2009 playoff game against América on 21 November 2009 in the second minute of the second half. He then scored two goals against Toluca in the semi-final. He also scored in the final against Cruz Azul, giving Monterrey the lead, and eventually dedicating the winning championship to his late brother.
He was called up to the Mexico national football team for the friendly matches against Bolivia on 24 February 2010 and New Zealand on 3 March 2010. Mexico defeated Bolivia 5-0, in which de Nigris entered to the game as a substitute. He started in his first game for Mexico against New Zealand, in which he played the first forty-five minutes, until being taken off at half-time. Mexico would win 2-0. Aldo would be left out of Javier Aguirre's 23-man squad for the 2010 FIFA World Cup due to an ankle injury, in which he took 12 weeks to recover.
de Nigris was named in the 23-man squad to participate in the CONCACAF Gold Cup. On 5 June he scored the second goal in the 5-0 over El Salvador after coming on as a substitute in the second-half. On 9 June de Nigris again scored after coming off the bench in a 5-0 win over Cuba. Three days later, he would score again coming on in the second half in the quarter-final match against Guatemala. After Mexico and Honduras held each other to a 0-0 draw in the semi-final match, de Nigris opened the score in the first half of extra-time, heading in a corner kick. Mexico would win the match 2-0, thus advancing to the final.