Bacterial neuraminidase

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BNR/Asp-box repeat
PDB 1euu EBI.jpg
Structure of a bacterial sialidase.[1]
Identifiers
Symbol BNR
Pfam PF02012
Pfam clan CL0434
InterPro IPR002860
SCOP 1euu
SUPERFAMILY 1euu

Bacterial neuraminidase is type of neuraminidase and a virulence factor for many bacteria including Bacteroides fragilis and Pseudomonas aeruginosa. Its function is to cleave a sialic acid residue off ganglioside-GM1 (a modulator of cell surface and receptor activity) turning it into asialo-GM1 to which type 4 pilli (attachment factors) bind preferentially.

References[edit]

  1. ^ Gaskell A, Crennell S, Taylor G (November 1995). "The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll". Structure 3 (11): 1197–205. doi:10.1016/s0969-2126(01)00255-6. PMID 8591030.