Maltase-glucoamylase

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"MGAM" redirects here. For other uses, see MGAM (disambiguation).
Maltase-glucoamylase (alpha-glucosidase)
PDB 2qly EBI.png
PDB rendering based on 2qly.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MGAM ; MG; MGA
External IDs OMIM154360 MGI1203495 HomoloGene130099 ChEMBL: 2074 GeneCards: MGAM Gene
EC number 3.2.1.20, 3.2.1.3
Orthologs
Species Human Mouse
Entrez 8972 232714
Ensembl ENSG00000257335 ENSMUSG00000068587
UniProt O43451 B5THE2
RefSeq (mRNA) NM_004668 NM_001171003
RefSeq (protein) NP_004659 NP_001164474
Location (UCSC) Chr 7:
141.61 – 141.81 Mb
Chr 6:
40.63 – 40.77 Mb
PubMed search [1] [2]

Maltase-glucoamylase, intestinal is an enzyme that in humans is encoded by the MGAM gene.[1][2]

Maltase-glucoamylase is alpha-glucosidase digestive enzyme. It consists of two subunits with differing substrate specificity. Recombinant enzyme studies have shown that its N-terminal catalytic domain has highest activity against maltose, while the C-terminal domain has a broader substrate specificity and activity against glucose oligomers.[3] In the small intestine, this enzyme works in synergy with sucrase-isomaltase and alpha-amylase to digest the full range of dietary starches.

See also[edit]

References[edit]

  1. ^ "Entrez Gene: maltase-glucoamylase (alpha-glucosidase)". 
  2. ^ Nichols BL, Eldering J, Avery S, Hahn D, Quaroni A, Sterchi E (January 1998). "Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase". J. Biol. Chem. 273 (5): 3076–81. doi:10.1074/jbc.273.5.3076. PMID 9446624. 
  3. ^ Quezada-Calvillo R, Sim L, Ao Z, Hamaker BR, Quaroni A, Brayer GD, Sterchi EE, Robayo-Torres CC, Rose DR, Nichols BL (2008). "Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit". J. Nutr. 138 (4): 685–92. PMID 18356321. 

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