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Heparanase 2 (inactive)
Symbols HPSE2 ; HPA2; HPR2; UFS; UFS1
External IDs OMIM613469 HomoloGene19680 GeneCards: HPSE2 Gene
RNA expression pattern
PBB GE HPSE2 220927 s at tn.png
More reference expression data
Species Human Mouse
Entrez 60495 545291
Ensembl ENSG00000172987 ENSMUSG00000074852
UniProt Q8WWQ2 B2RY83
RefSeq (mRNA) NM_001166244 NM_001081257
RefSeq (protein) NP_001159716 NP_001074726
Location (UCSC) Chr 10:
100.22 – 101 Mb
Chr 19:
42.79 – 43.39 Mb
PubMed search [1] [2]

Heparanase-2 is an enzyme that in humans is encoded by the HPSE2 gene.[1][2]

It may be associated with urofacial syndrome.[3]


  1. ^ McKenzie E, Tyson K, Stamps A, Smith P, Turner P, Barry R, Hircock M, Patel S, Barry E, Stubberfield C, Terrett J, Page M (Oct 2000). "Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member". Biochem Biophys Res Commun 276 (3): 1170–7. doi:10.1006/bbrc.2000.3586. PMID 11027606. 
  2. ^ "Entrez Gene: HPSE2 heparanase 2". 
  3. ^ Daly SB, Urquhart JE, Hilton E et al. (June 2010). "Mutations in HPSE2 Cause Urofacial Syndrome". Am J Hum Genet 86 (6): 963–969. doi:10.1016/j.ajhg.2010.05.006. PMC 3032078. PMID 20560210. 

Further reading[edit]

  • D'Souza SS, Fazleabas AT, Banerjee P et al. (2008). "Decidual heparanase activity is increased during pregnancy in the baboon (Papio anubis) and in in vitro decidualization of human stromal cells". Biol. Reprod. 78 (2): 316–23. doi:10.1095/biolreprod.107.063891. PMID 17989358. 
  • Bar-Sela G, Kaplan-Cohen V, Ilan N et al. (2006). "Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival". Histopathology 49 (2): 188–93. doi:10.1111/j.1365-2559.2006.02469.x. PMID 16879396. 
  • Beckhove P, Helmke BM, Ziouta Y et al. (2005). "Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis". Clin. Cancer Res. 11 (8): 2899–906. doi:10.1158/1078-0432.CCR-04-0664. PMID 15837740. 
  • Ogishima T, Shiina H, Breault JE et al. (2005). "Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer". Clin. Cancer Res. 11 (3): 1028–36. PMID 15709168. 
  • Wang Z, Xu H, Jiang L et al. (2005). "Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma". Mod. Pathol. 18 (2): 205–11. doi:10.1038/modpathol.3800282. PMID 15475937. 
  • Deloukas P, Earthrowl ME, Grafham DV et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.