Collagen, type VIII, alpha 1

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Collagen, type VIII, alpha 1
Protein COL8A1 PDB 1o91.png
PDB rendering based on 1o91.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols COL8A1 ; C3orf7
External IDs OMIM120251 MGI88463 HomoloGene22423 GeneCards: COL8A1 Gene
RNA expression pattern
PBB GE COL8A1 221152 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1295 12837
Ensembl ENSG00000144810 ENSMUSG00000068196
UniProt P27658 Q00780
RefSeq (mRNA) NM_001850 NM_007739
RefSeq (protein) NP_001841 NP_031765
Location (UCSC) Chr 3:
99.36 – 99.52 Mb
Chr 16:
57.62 – 57.75 Mb
PubMed search [1] [2]

Collagen alpha-1(VIII) chain is a protein that in humans is encoded by the COL8A1 gene.[1][2]

This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same isoform have been observed.[2]

References[edit]

  1. ^ Muragaki Y, Mattei MG, Yamaguchi N, Olsen BR, Ninomiya Y (Jun 1991). "The complete primary structure of the human alpha 1 (VIII) chain and assignment of its gene (COL8A1) to chromosome 3". Eur J Biochem 197 (3): 615–22. doi:10.1111/j.1432-1033.1991.tb15951.x. PMID 2029894. 
  2. ^ a b "Entrez Gene: COL8A1 collagen, type VIII, alpha 1". 

Further reading[edit]