Collagen, type XVI, alpha 1

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Collagen, type XVI, alpha 1
Identifiers
Symbols COL16A1 ; 447AA
External IDs OMIM120326 MGI1095396 HomoloGene1397 GeneCards: COL16A1 Gene
RNA expression pattern
PBB GE COL16A1 204345 at tn.png
PBB GE COL16A1 gnf1h03616 at tn.png
PBB GE COL16A1 gnf1h03617 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1307 107581
Ensembl ENSG00000084636 ENSMUSG00000040690
UniProt Q07092 Q8BLX7
RefSeq (mRNA) NM_001856 NM_028266
RefSeq (protein) NP_001847 NP_082542
Location (UCSC) Chr 1:
32.12 – 32.17 Mb
Chr 4:
130.05 – 130.1 Mb
PubMed search [1] [2]

Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene.[1][2]

Function[edit]

This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion.[2]

References[edit]

  1. ^ Pan TC, Zhang RZ, Mattei MG, Timpl R, Chu ML (Aug 1992). "Cloning and chromosomal location of human alpha 1(XVI) collagen". Proc Natl Acad Sci U S A 89 (14): 6565–9. doi:10.1073/pnas.89.14.6565. PMC 49542. PMID 1631157. 
  2. ^ a b "Entrez Gene: COL16A1 collagen, type XVI, alpha 1". 

Further reading[edit]

  • Yamaguchi N, Kimura S, McBride OW, Hori H, Yamada Y, Kanamori T, Yamakoshi H, Nagai Y (1993). "Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments.". J. Biochem. 112 (6): 856–63. PMID 1284248. 
  • Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells.". Matrix Biology 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976. 
  • Sires UI, Dublet B, Aubert-Foucher E, van der Rest M, Welgus HG (1995). "Degradation of the COL1 domain of type XIV collagen by 92-kDa gelatinase.". J. Biol. Chem. 270 (3): 1062–7. doi:10.1074/jbc.270.3.1062. PMID 7836360. 
  • Tillet E, Mann K, Nischt R, Pan TC, Chu ML, Timpl R (1995). "Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain.". Eur. J. Biochem. 228 (1): 160–8. doi:10.1111/j.1432-1033.1995.tb20245.x. PMID 7882999. 
  • Grässel S, Timpl R, Tan EM, Chu ML (1997). "Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells.". Eur. J. Biochem. 242 (3): 576–84. doi:10.1111/j.1432-1033.1996.0576r.x. PMID 9022684. 
  • Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (March 2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells.". Matrix biology : journal of the International Society for Matrix Biology 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976. 
  • Kassner A, Hansen U, Miosge N, Reinhardt DP, Aigner T, Bruckner-Tuderman L, Bruckner P, Grässel S (2004). "Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils.". Matrix Biol. 22 (2): 131–43. doi:10.1016/S0945-053X(03)00008-8. PMID 12782140. 
  • Kassner A, Tiedemann K, Notbohm H, Ludwig T, Mörgelin M, Reinhardt DP, Chu ML, Bruckner P, Grässel S (2004). "Molecular structure and interaction of recombinant human type XVI collagen.". J. Mol. Biol. 339 (4): 835–53. doi:10.1016/j.jmb.2004.03.042. PMID 15165854. 
  • Eble JA, Kassner A, Niland S, Mörgelin M, Grifka J, Grässel S (2006). "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains.". J. Biol. Chem. 281 (35): 25745–56. doi:10.1074/jbc.M509942200. PMID 16754661. 

External links[edit]