Collagen, type XVI, alpha 1

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Collagen, type XVI, alpha 1
Symbols COL16A1 ; 447AA
External IDs OMIM120326 MGI1095396 HomoloGene1397 GeneCards: COL16A1 Gene
RNA expression pattern
PBB GE COL16A1 204345 at tn.png
PBB GE COL16A1 gnf1h03616 at tn.png
PBB GE COL16A1 gnf1h03617 x at tn.png
More reference expression data
Species Human Mouse
Entrez 1307 107581
Ensembl ENSG00000084636 ENSMUSG00000040690
UniProt Q07092 Q8BLX7
RefSeq (mRNA) NM_001856 NM_028266
RefSeq (protein) NP_001847 NP_082542
Location (UCSC) Chr 1:
32.12 – 32.17 Mb
Chr 4:
130.05 – 130.1 Mb
PubMed search [1] [2]

Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene.[1][2]

This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion.[2]

Further reading[edit]

  • Yamaguchi N, Kimura S, McBride OW, et al. (1993). "Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments.". J. Biochem. 112 (6): 856–63. PMID 1284248. 
  • Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells.". Matrix Biology 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976. 


  1. ^ Pan TC, Zhang RZ, Mattei MG, Timpl R, Chu ML (Aug 1992). "Cloning and chromosomal location of human alpha 1(XVI) collagen". Proc Natl Acad Sci U S A 89 (14): 6565–9. doi:10.1073/pnas.89.14.6565. PMC 49542. PMID 1631157. 
  2. ^ a b "Entrez Gene: COL16A1 collagen, type XVI, alpha 1".