|David Henry Gorski|
|Institutions||Wayne State University
Barbara Ann Karmanos Cancer Institute
|Alma mater||Case Western Reserve University
University of Michigan
|Doctoral advisor||Kenneth Walsh|
David H. Gorski is an American surgical oncologist, Professor of surgery at Wayne State University, and a surgical oncologist at the Barbara Ann Karmanos Cancer Institute, specializing in breast cancer surgery. He is a critic of alternative medicine and the anti-vaccination movement. He is the author of a blog, Respectful Insolence, and is the managing editor of the website, Science-Based Medicine.
Gorski received his M.D. from the University of Michigan in 1988. He then completed his residency in general surgery at the University Hospitals of Cleveland, taking time off in the middle to acquire a Ph.D. in cellular physiology from Case Western Reserve University in 1994 with a dissertation entitled: "Homeobox Gene Expression and Regulation in Vascular Myocytes". After completing his residency, he completed a research fellowship in surgical oncology at the University of Chicago.
Gorski was previously Assistant Professor of Surgery at the Cancer Institute of New Jersey and the UMDNJ-Robert Wood Johnson Medical School in New Brunswick, NJ, as well as a member of the Joint Graduate Program in Cell & Developmental Biology at Rutgers University in Piscataway, NJ and The Cancer Institute of New Jersey. He became the Medical Director of the Alexander J. Walt Comprehensive Breast Center at the Barbara Ann Karmanos Cancer Institute in 2010 and was appointed co-director of the Michigan Breast Oncology Quality Initiative in 2013. Gorski is a Professor of Surgery and Oncology at the Wayne State University School of Medicine, whose laboratory conducts research on transcriptional regulation of vascular endothelial cell phenotype, as well as the role of metabotropic glutamate receptors in breast cancer. He is the cancer liaison physician for the American College of Surgeons Committee on Cancer, the founder of the Institute for Science in Medicine and a member of the American Society of Clinical Oncology.
In 2007 Gorski received the Advanced Clinical Research Award in Breast Cancer from the American Society of Clinical Oncology. Gorski was also awarded research grants by The Breast Cancer Research Foundation in 2008, 2009, and 2010.
Gorski's article, "Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation", characterizing the effects of angiogenesis inhibitors on the effectiveness of anti-tumor therapies has been cited over 900 times according to PubMed. This research has been used in anti-tumor therapeutic research, including an observation that angiogenesis inhibitors enhanced the therapeutic effects of ionizing radiation "by preventing repair of radiation damage to endothelial cells," and in determining the potential of combinational therapies to allow reduction of the dosages required in toxic conventional treatments while sustaining tumor regression when combined with specific antibodies and radiative therapies.
Gorski's work with Helena Mauceri and others, published in Nature as, Combined effects of angiostatin and ionizing radiation in antitumour therapy on research into the "combined effects of angiostatin" (a protein occurring in several animal species) "and ionizing radiation in anti-tumor therapy" led to investigation into the selective destruction of tumor cells, which according to a study by Gregg L. Semenza (citing Mauceri and others), "are more hypoxic than normal cells," allowing for "tumor cells to be killed without major systemic side effects."
The article, Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5 by Gorski and Yun Chen, into the use of microRNA to regulate angiogenesis led to research by Jason E. Fish's group at the University of California, San Francisco, into the use of microRNA to regulate blood vessel development, limiting tumor growth. Citing Chen and Gorski's research, Fish wrote that "several broadly expressed microRNAs regulate in vitro endothelial cell behavior, including proliferation, migration, and the ability to form capillary networks", and sought to describe the in vivo functionality of a specific set of microRNAs and their targets; the group was able to isolate a particular microRNA (miR-126) as the most highly enriched in endothelial cells.
Skepticism of CAM
Gorski is an outspoken skeptic of Complementary and Alternative Medicine (CAM). In 2006, Gorski, under the pen name "Orac”, began writing a blog entitled Respectful Insolence at the ScienceBlogs website. In 2008 Gorski used his real name when he started blogging at Science-Based Medicine (he continues to use 'Orac' for Respectful Insolence). He is currently their managing editor, and has posted on issues at the intersection of medicine and pseudoscience, including the anti-vaccination movement, alternative therapies, and cancer research and treatment. According to Gorski, in 2010 members of the anti-vaccine blog Age of Autism wrote to the board of directors at Wayne State University and asked that he be prevented from blogging. He has contributed considerable parts of the James Randi Education Foundation's series of EBooks, the Science Based Medicine Guides. He is also a fellow of the Committee for Skeptical Inquiry.
Gorski was a speaker at The Amaz!ng Meeting in 2009, 2010, 2012 and 2013. He has also participated in numerous panels on alternative medicine. He called attention to a paper by John P. A. Ioannidis on problems with published research.
Gorski has commented on the increasing infiltration of pseudoscience in the medical field with the use of alternative therapies, the use of acupuncture for treatment of soldiers, "detox" cleanses, and dietary treatment of autism.
He advocates for openness of the results of clinical trials and the use of only evidence-based medicine to treat diseases. He has been critical of Senator Tom Harkin's support of the National Center for Complementary and Alternative Medicine (NCCAM). He has criticized the National Institutes of Health (NIH) and NCCAM for funding and publishing research on, “treatment modalities that are inherently unscientific, being as they are based on prescientific or demonstrably incorrect understandings of human physiology and disease”, and has commented on the ethics, methods, and results of the study of alternative medicine.
Gorski has spoken out against the popularization of what he describes as pseudoscience by the media and celebrities such as Oprah Winfrey, Bill Maher, Ann Coulter, and the Huffington Post. In June 2013 Gorski said he supported healthcare professionals speaking out against poor medical practices and the sale of "dubious therapies."
Gorski was interviewed by WPRR in 2012. He called the co-sponsorship of Integrative Medicine Day by the American Medical Students Association “an infiltration of quackademic medicine” and was described by the pro-CAM science writer David H. Freedman as "one of the more prickly anti-alternative-medicine warriors."
In 2014, Gorski and fellow skeptic Steven Novella published an article denouncing clinical trials of integrative medicine and arguing that such trials "degrade the scientific basis of medicine" by, according to the Calcutta Telegraph, "portraying formulations whose basis rests on pre-scientific thinking as though they were supported by science."
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- Gorski, David H.; Beckett, Michael A.; Jaskowiak, Nora T.; Calvin, Douglas P. et al. (15 July 1999). "Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation". Cancer Research 59 (14): 3374–3378. PMID 10416597. Retrieved 21 June 2013.
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- Mauceri, Helena J.; Hanna, Nader N.; Beckett, Michael A.; Gorski, David H. et al. (16 July 1998). "Combined effects of angiostatin and ionizing radiation in antitumour therapy". Nature 394 (6690): 287–291. doi:10.1038/28412. PMID 9685160. Retrieved 20 June 2013.
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- Chen, Yun; Gorski, David H. (1 February 2008). "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5". Blood 111 (3): 1217–1226. doi:10.1182/blood-2007-07-104133. PMC 2214763.
- Fish, Jason E.; Santoro, Massimo M.; Morton, Sarah U.; Yu, Sangho et al. (12 August 2008). "miR-126 Regulates Angiogenic Signaling and Vascular Integrity". Developmental Cell 15 (2): 272–284. doi:10.1016/j.devcel.2008.07.008. PMC 2604134. Retrieved 22 June 2013.
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- Respectful Insolence, Gorski's blog. Publisher: ScienceBlogs
- Gorski's presentation at National Science Foundation