Foreskin

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This article is about human foreskin. For foreskin in other mammals, see Penile sheath.

Foreskin
Foreskin fully covering the glans penis
Details
PrecursorGenital tubercle, urogenital folds
SystemMale reproductive system
ArteryDorsal artery of the penis
VeinDorsal veins of the penis
NerveDorsal nerve of the penis
Identifiers
LatinPraeputium
MeSHD052816
TA98A09.4.01.011
TA23675
FMA19639
Anatomical terminology

In male human anatomy, the foreskin, also known as the prepuce, is the double-layered fold of skin, mucosal and muscular tissue at the distal end of the human penis that covers the glans penis and urinary meatus.[1] The foreskin is attached to the glans by an elastic band of tissue, known as the frenulum.[2] The mucocutaneous junction of the prepuce is the area where the outer skin meets with the inner preputial mucosa.[3] The foreskin is mobile, fairly stretchable and sustains the glans in a moist environment.[4] Except for humans, the feature appears in the male sexual organs of all primates and the vast majority of mammals.[5][6]

In humans, foreskin length varies widely and coverage of the glans in a flaccid and erect state can also vary.[7] The foreskin is fused to the glans at birth and is generally not retractable in infancy and early childhood.[8] Inability to retract the foreskin in childhood should not be considered a problem unless there are other symptoms.[9] Retraction of the foreskin is not recommended until it loosens from the glans before or during puberty.[9] In adults, it is typically retractable over the glans, given normal development.[9] The male prepuce is anatomically homologous to the clitoral hood in females.[10][11] The foreskin may become subject to a number of pathological conditions,[a] although most of these are rare and easily treatable.[12]

Structure

Different studies estimating timing of preputial seperation in children and teens.
Infographic on anatomy and function of the foreskin. Although depicted in the illustration, the existence of the so called "ridged band" has been questioned.

External

The outside of the foreskin is a continuation of the skin that surrounds the shaft of the penis and is covered by a keratinized stratified squamous epithelium. The inner foreskin is a continuation of the epithelium that covers the glans and is made up of glabrous squamous mucous membrane, like the inside of the eyelid or the mouth.[13] The mucosal aspect of the prepuce has a great capacity for self-repair.[14] The area of the outer foreskin measures 7–100 cm2,[15] and the inner foreskin measures 18–68 cm.2[7] The mucocutaneous zone occurs where the outer and inner foreskin meet. The foreskin is free to move after it separates from the glans, which usually occurs before or during puberty. The inner foreskin is attached to the glans by the frenulum, a highly vascularized tissue of the penis.[16] The World Health Organization states that "the frenulum forms the interface between the outer and inner foreskin layers, and when the penis is not erect, it tightens to narrow the foreskin opening.[16]

Subcutaneous

The human foreskin is a laminar structure that is made up of outer skin, mucosal epithelium, lamina propia, dartos fascia and dermis.[14][5] The superficial dartos fascia, formerly called the peripenic muscle, is one of the two sheaths of smooth muscle tissue found below the penile skin, along with the underlying Buck's fascia or deep fascia of the penis.[17] The dartos fascia extents within the skin of the prepuce and contains an abuncance of elastic fibers.[18] These fibers form a whorl at the tip of the foreskin, known as the preputial orifice, which is narrow during infancy and childhood.[19][5] The dartos fascia is sensitive to temperature and reacts to temperature changes by expanding and contracting.[20] The fascia is only loosely connected with the underlying tissue, so that it provides the mobility and elasticity of the penile skin.[18] Langerhans cells are immature dendritic cells that are found in all areas of the penile epithelium, but are most superficial in the inner surface of the foreskin.[21]

As a continuation of the human penile skin, the prepuce receives somatosensory innervation from the bilateral dorsal nerve of the penis and branches of the perineal nerve, and autonomic innervation from the pelvic plexus.[22][23] The somatosensory receptors that are found in the prepuce are both nociceptors and mechanoreceptors, with a predominace of Meissner's corpuscles.[22][24] Blood supply of the prepuce is provided by the preputial artery, a division of the axial and dorsal artery of the penis.[17] The axial and dorsal arteries that run within the penile skin unite through perforating branches and give off the preputial arteries before they reach the corona of the glans.[25][26] The preputial vein, an extension of the superficial dorsal vein, receives blood from the prepuce and connects to the larger dorsal veins of the penis that drain the rest of the penile shaft.[27][28]

In 1996, following a study of 22 cadavers, retired pathologist John Taylor published a paper in which he proposed that the pleated skin of the distal foreskin, which he called ridged band, was a distinct anatomical structure that played an important role in sexual function.[29][30][31] A 2015 review by Cox and colleagues said that the feature was particular to some men and that his illustrations had been inconsistent.[32]

Development

File:Foreskin development.jpg
Development stages of the penis and prepuce from gestation to puberty.

Gestation

The penis develops from a primordial phallic structure that forms in the embryo during the early weeks of pregnancy, known as the genital tubercle.[33] Initially undifferentiated, the tubercle develops into a penis depending on the exposure to male hormones secreted by the testes.[34] The differentiation of the external sexual organs will be evident between twelve and sixteen weeks of gestation.[35][36]

Preputial development is initiated at around eleven weeks or earlier and continues up to eighteen weeks.[37][38][39] Historically, the theories regarding the stages of preputial development during gestation fall into two main ideas.[40] The earliest report by Schweigger-Seidel (1866)[41] and later Hunter (1935)[42] suggested the formation of the prepuce out of dorsal skin and its progressive distal extension to completelly cover and eventually fuse with the epithelium of the glans.[40] Glenister (1956)[43] expanded the theory suggesting that the preputial fold results as an ingrowth of the cellular lamina, which rolls outwards over the glans, but with the resultant preputial lamina also expanding backwards to form an ingrowing fold at the coronal sulcus.[40] The same idea was also described by Cold & Taylor (1999),[5] Johnson (1920)[44] and others.

By eleven and twelve weeks of gestation, the process of preputial formation is evident as a thickening of the epidermis that seperates from the penis creating a raised fold, known as the preputial fold.[45] This novel structure expands dorsolaterally over the base of the developing glans.[46][47] At thirteen weeks, the prepuce has not yet extended to the distal tip of the glans covering only a part of its surface.[48] By sixteen weeks, the bilateral preputial folds cover most of the glans and the ventral sides of the prepuce fuse in the midline.[49] The penile raphe, the continuation of the perineal raphe in human males, occurs on the ventral side of the penis as a manifestation of the fusion of the urethral and preputial folds.[50] The dorsal nerve of the penis, which is present as early as nine weeks of gestation, completely expands through branches to the distal end of the glans and prepuce by sixteen weeks.[51] At nineteen weeks, foreskin development is complete.[38] Towards the end of the second trimester,[52] the glans and the prepuce have completely fused together by a common membrane, known as the balanopreputial lamina. This membrane keeps the organs inseparable in infancy and early childhood.[53] The phenomenon of non-retractile foreskin in children is known as physiologic phimosis and it naturally starts to resolve before or during puberty.[54] By the end of puberty, most boys have a fully retractable foreskin.[55]

Variability

Once the foreskin has naturally separated from the glans, the foreskin's two layers of outer skin and inner mucosa can be retracted to reveal the glans and inner foreskin.

In children, the foreskin usually covers the glans completely but in adults it may not. During erection, the degree of automatic foreskin retraction varies considerably; in some adults, when the foreskin is longer than the erect penis, it will not spontaneously retract upon erection. In this case, the foreskin remains covering all or some of the glans until retracted manually or by sexual activity. The foreskin can be classified as long, when the preputial orifice extents beyond the glans, medium, when the preputial orifice is located around the meatus, and short, when most of the glans is exposed.[56] The variation of long foreskin was regarded by Chengzu (2011) as 'prepuce redundant'. Frequent retraction and washing under the foreskin is suggested for all adults, particularly for those with a long or 'redundant' foreskin.[57] Some males, according to Xianze (2012), may be reluctant for their glans to be exposed because of discomfort when it chafes against clothing, although the discomfort on the glans was reported to diminish within one week of continuous exposure.[58] Guochang (2010) states that for those whose foreskins are too tight to retract or have some adhesions, forcible retraction should be avoided since it may cause injury.[59]

Function

The foreskin typically covers the glans when the penis is not erect (top image), but generally retracts upon erection (bottom image). Coverage of the glans in a flaccid and erect state varies depending on foreskin length.

The World Health Organization (WHO) stated in 2007 that there was "debate about the role of the foreskin, with possible functions including keeping the glans moist, protecting the developing penis in utero, or enhancing sexual pleasure due to the presence of nerve receptors".[16] The foreskin helps to provide sufficient skin during an erection.[60] The foreskin protects the glans.[61] In infants, it protects the glans from ammonia and feces in diapers, which reduces the incidence of meatal stenosis. And the foreskin helps prevent the glans from getting abrasions and trauma throughout life.[60] The fold of the prepuce produces sub-preputial wetness, helping to maintain the naturally moisturized state of the glans penis. The foreskin contains Meissner's corpuscles, which are nerve endings involved in fine-touch sensitivity. A study of skin samples found that, compared to other hairless skin areas on the body, the Meissner's index was highest in the finger tip (0.96) and lowest in the foreskin (0.28) suggested that the foreskin has the least sensitive hairless tissue of the body.[32]

Evolution

The foreskin is present in the vast majority of mammals, including non-human primates, such as the chimpanzee.[16] In primates, the foreskin is present in the genitalia of both sexes and likely has been present for millions of years of evolution.[62] The evolution of complex penile morphologies like the foreskin may have been influenced by females.[63][64][65]

In modern times, there is controversy regarding whether the foreskin is a vital or vestigial structure.[66] In 1949, British physician Douglas Gairdner noted that the foreskin plays an important protective role in newborns. He wrote, "It is often stated that the prepuce is a vestigial structure devoid of function... However, it seems to be no accident that during the years when the child is incontinent the glans is completely clothed by the prepuce, for, deprived of this protection, the glans becomes susceptible to injury from contact with sodden clothes or napkin."[66] During the physical act of sex, the foreskin reduces friction, which can reduce the need for additional sources of lubrication.[66] The College of Physicians and Surgeons of British Columbia has written that the foreskin is "composed of an outer skin and an inner mucosa that is rich in specialized sensory nerve endings and erogenous tissue."[61] "Some medical researchers... claim circumcised men enjoy sex just fine and that, in view of recent research on HIV transmission, the foreskin causes more trouble than it’s worth."[66] In the March 2017 publication of the Global Health Journal: Science and Practice, Morris and Krieger wrote, "The variability in foreskin size is consistent with the foreskin being a vestigial structure."[67]

Clinical significance

The foreskin can be involved in balanitis, phimosis, sexually transmitted infection and penile cancer.[68] The American Academy of Pediatricians' 2012 technical report on circumcision found that the foreskin tends to harbor micro-organisms that can lead to urinary tract infections in infants and tend to contribute to the transmission of sexually transmitted infections in adults.[69]

Frenulum breve is a frenulum that is insufficiently long to allow the foreskin to fully retract, which may lead to discomfort during intercourse.

Phimosis is a condition where the foreskin of an adult cannot be retracted properly. Phimosis can be treated by using topical steroid ointments and using lubricants during sex; for severe cases circumcision may be necessary.[70] Posthitis is an inflammation of the foreskin.

A condition called paraphimosis may occur if a tight foreskin becomes trapped behind the glans and swells as a restrictive ring. This can cut off the blood supply, resulting in ischemia of the glans penis.[70]

Lichen sclerosus is a chronic, inflammatory skin condition that most commonly occurs in adult women, although it may also be seen in men and children. Topical clobetasol propionate and mometasone furoate were proven effective in treating genital lichen sclerosus.[71]

Some birth defects of the foreskin can occur; all of them are rare. In aposthia there is no foreskin at birth,[72]: 37–39  in micropathia the foreskin does not cover the glans,[72]: 41–45  and in macroposthia, also called and congenital megaprepuce, the foreskin extends well past the end of the glans.[72]: 47–50 

It has been found that larger foreskins place uncircumcised men at an increased risk for HIV infection[73] most likely due to the larger surface area of inner foreskin and the high concentration of Langerhans cells.[74]

Society and culture

Modifications

See also: Circumcision and Foreskin restoration
Preputioplasty:
Fig 1. Penis with tight phimotic ring making it difficult to retract the foreskin.
Fig 2. Foreskin retracted under anaesthetic with the phimotic ring or stenosis constricting the shaft of the penis and creating a "waist".
Fig 3. Incision closed laterally.
Fig 4. Penis with the loosened foreskin replaced over the glans.

Circumcision is the removal of the foreskin, either partially or completely. It is most commonly performed as an elective procedure for prophylactic, cultural, or religious reasons.[75][76]: 257  Circumcision may also be performed on children or adults to treat phimosis, balanitis, and other pathologies.[77]: 166  The ethics of circumcision in children is a source of controversy.[78][79][80]

As of 2012, no successful technique to reconstruct a circumcised foreskin had been published.[81]: 181  Some men have used weights to stretch the skin of the penis to regrow a foreskin; the resulting tissue does cover the glans but does not replicate the features of a foreskin.[82]

Other cultural or aesethetic practices include genital piercings involving the foreskin and slitting the foreskin.[83]

Preputioplasty is the most common foreskin reconstruction technique, most often done when a boy is born with a foreskin that is too small;[81]: 177  a similar procedure is performed to relieve a tight foreskin without resorting to circumcision.[81]: 181 

Foreskin restoration and regeneration

Main article: Foreskin restoration

Foreskin restoration is the process of expanding the skin on the penis to reconstruct an organ similar to the foreskin, which has been removed by circumcision or injury.[84] Foreskin restoration is of ancient origin, when surgical means were taken to lengthen the foreskin of individuals born with either a short foreskin that did not cover the glans completely[85] or a completely exposed glans as a result of circumcision.[86] Foreskin restoration has been reported as having beneficial emotional results in some men, and has been proposed as a treatment for feelings of sexual violation or mutilation in adult men for circumcisions that were performed on them without consent.[87]

Foreskin restoration is primarily accomplished by stretching the residual skin of the penis, but surgical methods also exist. Some forms of restoration involve only partial regeneration in instances of a high-cut wherein the circumcisee feels that the circumciser removed too much skin and that there is not enough skin for erections to be comfortable.[84] Restoration creates a facsimile of the foreskin, but specialized tissues removed during circumcision such as the ridged band and frenulum cannot be reclaimed. Actual regeneration of the foreskin is experimental at this time.[88]

Foreskin-based products

Human neonatal dermal fibroblasts isolated from foreskin stained with calcein-AM. Such cells are commonly used in bioreactor and tissue engineering applications.

Foreskins obtained from circumcision procedures are frequently used by biochemical and micro-anatomical researchers to study the structure and proteins of human skin. In particular, foreskins obtained from newborns have been found to be useful in the manufacturing of more human skin.[89]

Foreskins of babies are also used for skin graft tissue,[90][91][92] and for β-interferon-based drugs.[93]

Foreskin-derived fibroblasts have been used in biomedical research,[94] and cosmetic applications.[95]

Sexual practices

The foreskin plays a role in the sexual practice of docking. Docking is a gay sexual practice, which involves mutual masturbation, by inserting the glans penis into the foreskin of another penis.

History

Foreskin was considered a sign of beauty, civility, and masculinity throughout the Greco-Roman world.[96] In ancient Greece, foreskins were valued, especially those that were longer in length.[97] The earliest known illustrative depiction of the foreskin dates back to Egyptian kingdoms.[98]

The foreskin has also been depicted in art from different historical ages:

Notes

  1. ^ such as phimosis, balanitis, and posthitis

References

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  37. ^ Liu, Xin; Liu, Ge; Shen, Joel; Yue, Aaron; Isaacson, Dylan; Sinclair, Adrian; Cao, Mei; Liaw, Aron; Cunha, Gerald R.; Baskin, Laurence (2018). "Human Glans and Preputial Development". Differentiation; Research in Biological Diversity. 103: 86–99. doi:10.1016/j.diff.2018.08.002. ISSN 0301-4681. PMC 6234068. PMID 30245194. Human preputial development begins at ~11 weeks of gestation [...] when the epithelium thickens on the dorsal aspect of the glans penis and forms the preputial placode [...] from which bilateral preputial laminar processes extend ventrally into the glanular mesenchyme
  38. ^ a b Favorito, Luciano Alves; Balassiano, Carlos Miguel; Costa, Waldemar Silva; Sampaio, Francisco José Barcellos (2012). "Development of the human foreskin during the fetal period". Histology and Histopathology. 27 (8): 1041–1045. doi:10.14670/HH-27.1041. ISSN 1699-5848. PMID 22763876. The complete foreskin was formed only in the fetuses at 18 and 19 WPC, in which the foreskin totally covered the glans.
  39. ^ Cunha, Gerald R.; Sinclair, Adrian; Cao, Mei; Baskin, Laurence S. (2020). "Development of the human prepuce and its innervation". Differentiation; Research in Biological Diversity. 111: 22–40. doi:10.1016/j.diff.2019.10.002. ISSN 0301-4681. PMC 6936222. PMID 31654825. ...the earliest stages (8 weeks) of human preputial development to advanced preputial development at 17 weeks of gestation.
  40. ^ a b c Cunha, Gerald R.; Sinclair, Adrian; Cao, Mei; Baskin, Laurence S. (2020). "Development of the human prepuce and its innervation". Differentiation; Research in Biological Diversity. 111: 22–40. doi:10.1016/j.diff.2019.10.002. ISSN 0301-4681. PMC 6936222. PMID 31654825.
  41. ^ Schweigger-Seidel, F. (1866). "Zur Entwickelung des Praeputium". Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin. 37 (2): 219–225. doi:10.1007/bf01935635. ISSN 0945-6317. S2CID 26136414.
  42. ^ Hunter, Richard H. (1935). "Notes on the Development of the Prepuce". Journal of Anatomy. 70 (Pt 1): 68–75. ISSN 0021-8782. PMC 1249280. PMID 17104576.
  43. ^ Glenister, T. W. (1956). "A consideration of the processes involved in the development of the prepuce in man". British Journal of Urology. 28 (3): 243–249. doi:10.1111/j.1464-410x.1956.tb04763.x. ISSN 0007-1331. PMID 13364260.
  44. ^ Johnson, Franklin P. (1920). "The Later Development of the Urethra in the Male". Journal of Urology. 4 (6): 447–501. doi:10.1016/s0022-5347(17)74157-2. ISSN 0022-5347.
  45. ^ Fahmy, Mohamed A. Baky (2020), Fahmy, Mohamed A. Baky (ed.), "Embryology of Prepuce", Normal and Abnormal Prepuce, Cham: Springer International Publishing, pp. 29–33, doi:10.1007/978-3-030-37621-5_4, ISBN 978-3-030-37621-5, retrieved 2022-11-15, The first indication of the onset of the developmental processes of the prepuce involved the appearance of a raised fold (the preputial fold), just at the coronary sulcus.
  46. ^ Liu, Xin; Liu, Ge; Shen, Joel; Yue, Aaron; Isaacson, Dylan; Sinclair, Adrian; Cao, Mei; Liaw, Aron; Cunha, Gerald R.; Baskin, Laurence (2018). "Human Glans and Preputial Development". Differentiation; Research in Biological Diversity. 103: 86–99. doi:10.1016/j.diff.2018.08.002. ISSN 0301-4681. PMC 6234068. PMID 30245194. Development of the prepuce is initiated by ~12 weeks with the appearance of a novel structure, the preputial placode, which is a dorsal thickening of the epidermis on the dorsal aspect of the developing glans penis.
  47. ^ Cunha, Gerald R.; Sinclair, Adrian; Cao, Mei; Baskin, Laurence S. (2020). "Development of the human prepuce and its innervation". Differentiation; Research in Biological Diversity. 111: 22–40. doi:10.1016/j.diff.2019.10.002. ISSN 0301-4681. PMC 6936222. PMID 31654825. The process of preputial lamina formation is initiated dorsally or dorsal-laterally in the proximal aspect of the glans at 11 to 12.5 weeks
  48. ^ Favorito, Luciano Alves; Balassiano, Carlos Miguel; Costa, Waldemar Silva; Sampaio, Francisco José Barcellos (2012). "Development of the human foreskin during the fetal period". Histology and Histopathology. 27 (8): 1041–1045. doi:10.14670/HH-27.1041. ISSN 1699-5848. PMID 22763876. The glans was partially covered by the foreskin in the fetus at 13 WPC
  49. ^ Liu, Xin; Liu, Ge; Shen, Joel; Yue, Aaron; Isaacson, Dylan; Sinclair, Adrian; Cao, Mei; Liaw, Aron; Cunha, Gerald R.; Baskin, Laurence (2018). "Human Glans and Preputial Development". Differentiation; Research in Biological Diversity. 103: 86–99. doi:10.1016/j.diff.2018.08.002. ISSN 0301-4681. PMC 6234068. PMID 30245194. From the lateral aspect of the preputial placode the bilateral preputial laminae expand ventrally until the preputial folds (foreskin) cover all of the glans, fusing in the ventral midline at ~16 weeks gestation.
  50. ^ Liu, Xin; Liu, Ge; Shen, Joel; Yue, Aaron; Isaacson, Dylan; Sinclair, Adrian; Cao, Mei; Liaw, Aron; Cunha, Gerald R.; Baskin, Laurence (2018). "Human Glans and Preputial Development". Differentiation; Research in Biological Diversity. 103: 86–99. doi:10.1016/j.diff.2018.08.002. ISSN 0301-4681. PMC 6234068. PMID 30245194. Formation of the prepuce occurs after formation of the urethra in the penile shaft. The penile raphe within the penile shaft is a manifestation of fusion of the urethral folds within the shaft
  51. ^ Cunha, Gerald R.; Sinclair, Adrian; Cao, Mei; Baskin, Laurence S. (2020). "Development of the human prepuce and its innervation". Differentiation; Research in Biological Diversity. 111: 22–40. doi:10.1016/j.diff.2019.10.002. ISSN 0301-4681. PMC 6936222. PMID 31654825. Examination of the ontogeny of innervation of the glans penis and prepuce reveals the presence of the dorsal nerve of the penis as early as 9 weeks of gestation. Nerve fibers enter the glans penis proximally and extend distally...to eventually reach the distal aspect of the glans and prepuce by 14 to 16 weeks of gestation.
  52. ^ Fahmy, Mohamed A. Baky (2020), Fahmy, Mohamed A. Baky (ed.), "Embryology of Prepuce", Normal and Abnormal Prepuce, Cham: Springer International Publishing, pp. 29–33, doi:10.1007/978-3-030-37621-5_4, ISBN 978-3-030-37621-5, retrieved 2022-11-15, Prepuce completely covering and fusing with the glans structure at around twenty-fourth week of gestation.
  53. ^ Carmack, Adrienne; Milos, Marilyn Fayre (2017). "Catheterization without foreskin retraction". Canadian Family Physician. 63 (3): 218–220. ISSN 0008-350X. PMC 5349724. PMID 28292801. The foreskin and glans are connected by the balanopreputial lamina, a membrane similar to the synechial membrane that connects the nail bed and the fingernail... This membrane and the small preputial opening prevent retraction in boys with normal physiologic phimosis.
  54. ^ Dave, Sumit; Afshar, Kourosh; Braga, Luis H.; Anderson, Peter (2018). "CUA guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants". Canadian Urological Association Journal. 12 (2): E76–E99. doi:10.5489/cuaj.5033. ISSN 1920-1214. PMC 5937400. PMID 29381458. the incidence of non-retractable physiological phimosis was 50% in grade 1 boys and decreased to 35% in grade 4 and 8% in grade 7 boys
  55. ^ McGregor, Thomas B.; Pike, John G.; Leonard, Michael P. (2007). "Pathologic and physiologic phimosis: Approach to the phimotic foreskin". Canadian Family Physician. 53 (3): 445–448. PMC 1949079. PMID 17872680. most foreskins will become retractile by adulthood.
  56. ^ Velazquez, Elsa F.; Bock, Adelaida; Soskin, Ana; Codas, Ricardo; Arbo, Manuel; Cubilla, Antonio L. (2003). "Preputial variability and preferential association of long phimotic foreskins with penile cancer: an anatomic comparative study of types of foreskin in a general population and cancer patients". The American Journal of Surgical Pathology. 27 (7): 994–998. doi:10.1097/00000478-200307000-00015. ISSN 0147-5185. PMID 12826892. S2CID 34091663.
  57. ^ Chengzu L (2011). "Health Care for Foreskin Conditions". Epidemiology of Urogenital Diseases. Beijing: People's Medical Publishing House.
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  61. ^ a b College of Physicians; Surgeons of British Columbia (2009). "Circumcision (Infant Male)" (PDF). Archived from the original (PDF) on February 15, 2012. Retrieved April 22, 2012.
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  67. ^ Morris BJ, Krieger JN, Klausner JD (March 2017). "CDC's Male Circumcision Recommendations Represent a Key Public Health Measure". Global Health: Science and Practice. 5 (1): 15–27. doi:10.9745/GHSP-D-16-00390. PMC 5478224. PMID 28351877.
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  69. ^ Blank, Susan; Brady, Michael; Buerk, Ellen; Carlo, Waldemar; Diekema, Douglas; Freedman, Andrew; Maxwell, Lynne; Wegner, Steven (September 2012). "Male circumcision". Pediatrics. 130 (3): e756–e785. doi:10.1542/peds.2012-1990. PMID 22926175.. The technical report was published in conjunction with an updated statement of policy on circumcision: Blank, Susan; Brady, Michael; Buerk, Ellen; Carlo, Waldemar; Diekema, Douglas; Freedman, Andrew; Maxwell, Lynne; Wegner, Steven (September 2012). "Circumcision policy statement" (PDF). Pediatrics. 130 (3): 585–586. doi:10.1542/peds.2012-1989. PMID 22926180. S2CID 207166111. Archived (PDF) from the original on 2017-09-01. Retrieved 2017-10-04.
  70. ^ a b "Phimosis (tight foreskin)". NHS Choices. 26 August 2015. Archived from the original on 22 September 2017. Retrieved 21 September 2017.
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  72. ^ a b c Fahmy M (2017). Congenital Anomalies of the Penis – Springer. Springer. ISBN 978-3-319-43310-3.
  73. ^ Van Howe RS, Sorrells MS, Snyder JL, Reiss MD, Milos MF (December 2016). "Letter from Van Howe et al Re: Examining Penile Sensitivity in Neonatally Circumcised and Intact Men Using Quantitative Sensory Testing: J. A. Bossio, C. F. Pukall and S. S. Steele J Urol 2016;195:1848-1853". The Journal of Urology. 196 (6): 1824. doi:10.1016/j.juro.2016.05.127. PMID 28181790.
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  76. ^ Cox G, Morris BJ (2012). "Chapter 21: Why Circumcision:From Prehistory to the Twenty-First Century". In Bolnick DA, Koyle M, Yosha A (eds.). Surgical Guide to Circumcision. London: Springer-Verlag. pp. 243–259. ISBN 978-1-4471-2858-8.
  77. ^ McClung C, Voelzke B (2012). "Chapter 14: Adult Circumcision". In Bolnick DA, Koyle M, Yosha A (eds.). Surgical Guide to Circumcision. London: Springer-Verlag. pp. 165–175. ISBN 978-1-4471-2858-8.
  78. ^ Boyle GJ, Svoboda JS, Price CP, Turner JN (2000). "Circumcision of healthy boys: Criminal assault?". Journal of Law and Medicine. 7: 301–310.
  79. ^ "Policy Statement On Circumcision". Royal Australasian College of Physicians. September 2004. Archived from the original (PDF) on 2008-07-20. Retrieved 2007-02-28. The Paediatrics and Child Health Division, The Royal Australasian College of Physicians (RACP) has prepared this statement on routine circumcision of infants and boys to assist parents who are considering having this procedure undertaken on their male children and for doctors who are asked to advise on or undertake it. After extensive review of the literature the RACP reaffirms that there is no medical indication for routine neonatal circumcision. Circumcision of males has been undertaken for religious and cultural reasons for many thousands of years. It remains an important ritual in some religious and cultural groups.…In recent years there has been evidence of possible health benefits from routine male circumcision. The most important conditions where some benefit may result from circumcision are urinary tract infections, HIV and later cancer of the penis.…The complication rate of neonatal circumcision is reported to be around 1% and includes tenderness, bleeding and unhappy results to the appearance of the penis. Serious complications such as bleeding, septicaemia and may occasionally cause death (1 in 550,000). The possibility that routine circumcision may contravene human rights has been raised because circumcision is performed on a minor and is without proven medical benefit. Whether these legal concerns are valid will be known only if the matter is determined in a court of law. If the operation is to be performed, the medical attendant should ensure this is done by a competent operator, using appropriate anaesthesia and in a safe child-friendly environment. In all cases where parents request a circumcision for their child the medical attendant is obliged to provide accurate information on the risks and benefits of the procedure. Up-to-date, unbiased written material summarizing the evidence should be widely available to parents. Review of the literature in relation to risks and benefits shows there is no evidence of benefit outweighing harm for circumcision as a routine procedure in the neonate.
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  85. ^

    Circumcised barbarians, along with any others who revealed the glans penis, were the butt of ribald humor. For Greek art portrays the foreskin, often drawn in meticulous detail, as an emblem of male beauty; and children with congenitally short foreskins were sometimes subjected to a treatment, known as epispasm, that was aimed at elongation.

    — Jacob Neusner, Approaches to Ancient Judaism, New Series: Religious and Theological Studies (1993), p. 149, Scholars Press.
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