Puberty is the process of physical changes by which a child's body matures into an adult body capable of sexual reproduction to enable fertilisation. It is initiated by hormonal signals from the brain to the gonads; the ovaries in a girl, the testes in a boy. In response to the signals, the gonads produce hormones that stimulate libido and the growth, function, and transformation of the brain, bones, muscle, blood, skin, hair, breasts, and sexual organs. Physical growth—height and weight—accelerates in the first half of puberty and is completed when the child has developed an adult body. Until the maturation of their reproductive capabilities, the pre-pubertal, physical differences between boys and girls are the genitalia, the penis and the vagina.
On average, girls begin puberty at ages 10–11; boys at ages 11–12. Girls usually complete puberty by ages 15–17, while boys usually complete puberty by ages 16–17. The major landmark of puberty for females is menarche, the onset of menstruation, which occurs on average between ages 12–13; for males, it is the first ejaculation, which occurs on average at age 13. In the 21st century, the average age at which children, especially girls, reach puberty is lower compared to the 19th century, when it was 15 for girls and 16 for boys. This can be due to any number of factors, including improved nutrition resulting in rapid body growth, increased weight and fat deposition, or exposure to endocrine disruptors such as xenoestrogens, which can at times be due to food consumption or other environmental factors. Puberty which starts earlier than usual is known as precocious puberty. Puberty which starts later than usual is known as delayed puberty.
Notable among the morphologic changes in size, shape, composition, and functioning of the pubertal body, is the development of secondary sex characteristics, the "filling in" of the child's body; from girl to woman, from boy to man. Derived from the Latin puberatum (age of maturity), the word puberty describes the physical changes to sexual maturation, not the psychosocial and cultural maturation denoted by the term "adolescent development" in Western culture, wherein adolescence is the period of mental transition from childhood to adulthood, which overlaps much of the body's period of puberty.
Differences between male and female puberty
Two of the most significant differences between puberty in girls and puberty in boys are the age at which it begins, and the major sex steroids involved.
Although there is a wide range of normal ages, girls typically begin the process of puberty at age 10 or 11; boys at ages 11–12. Girls usually complete puberty by ages 15–17, while boys usually complete puberty by ages 16–17. Any increase in height beyond the post-pubertal age is uncommon. Girls attain reproductive maturity about 4 years after the first physical changes of puberty appear. In contrast, boys accelerate more slowly but continue to grow for about 6 years after the first visible pubertal changes.
For boys, an androgen called testosterone is the principal sex hormone. While testosterone produces all boys' changes characterized as virilization, a substantial product of testosterone metabolism in males is estradiol. The conversion of testosterone to estradiol depends on the amount of body fat and estradiol levels in boys are typically much lower than in girls. The male "growth spurt" also begins later, accelerates more slowly, and lasts longer before the epiphyses fuse. Although boys are on average 2 cm shorter than girls before puberty begins, adult men are on average about 13 cm (5.2 inches) taller than women. Most of this sex difference in adult heights is attributable to a later onset of the growth spurt and a slower progression to completion, a direct result of the later rise and lower adult male levels of estradiol.
The hormone that dominates female development is an estrogen called estradiol. While estradiol promotes growth of breasts and uterus, it is also the principal hormone driving the pubertal growth spurt and epiphyseal maturation and closure. Estradiol levels rise earlier and reach higher levels in women than in men.
The hormonal maturation of females is considerably more complicated than in boys. The main steroid hormones, testosterone, estradiol, and progesterone as well as prolactin play important physiological functions in puberty. Gonadal steroidgenesis in girls starts with production of testosterone which is typically quickly converted to estradiol inside the ovaries. However the rate of conversion from testosterone to estradiol (driven by FSH/LH balance) during early puberty is highly individual, resulting in very diverse development patterns of secondary sexual characteristics. Production of progesterone in the ovaries begins with the development of ovulatory cycles in girls (during the lutheal phase of the cycle), before puberty low levels of progesterone are produced in the adrenal glands of both boys and girls.
Puberty is preceded by adrenarche, marking an increase of adrenal androgen production between ages 6-10. Adrenarche is sometimes accompanied by the early appearance of axillary and pubic hair. The first androgenic hair resulting from adrenarche can be also transient and disappear before the onset of true puberty.
The onset of puberty is associated with high GnRH pulsing, which precedes the rise in sex hormones, LH and FSH. Exogenous GnRH pulses cause the onset of puberty. Brain tumors which increase GnRH output may also lead to premature puberty.
The cause of the GnRH rise is unknown. Leptin might be the cause of the GnRH rise. Leptin has receptors in the hypothalamus which synthesizes GnRH. Individuals who are deficient in leptin fail to initiate puberty. The levels of leptin increase with the onset of puberty, and then decline to adult levels when puberty is completed. The rise in GnRH might also be caused by genetics. A study discovered that a mutation in genes encoding both Neurokinin B as well as the Neurokinin B receptor can alter the timing of puberty. The researchers hypothesized that Neurokinin B might play a role in regulating the secretion of Kisspeptin, a compound responsible for triggering direct release of GnRH as well as indirect release of LH and FSH.
Physical changes in boys
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Testicular size, penis size, fertility
In boys, testicular enlargement is the first physical manifestation of puberty (and is termed gonadarche). Testes in prepubertal boys change little in size from about 1 year of age to the onset of puberty, averaging about 2–3 cm in length and about 1.5–2 cm in width. The size of the testicles is among the parameters of the tanner scale for male genitals, from stage I which represents a volume of less than 1.5 ml, to stage V which represents a testicular volume of greater than 20 ml. Testicular size reaches maximal adult size about 6 years after the onset of puberty. After the boy's testicles have enlarged and developed for about one year, the length and then the breadth of the shaft of the penis will increase and the glans penis and corpora cavernosa will also start to enlarge to adult proportions. While 18–20 cm3 is an average adult size, there is wide variation in testicular size in the normal population.
The testes have two primary functions: to produce hormones and to produce sperm. The Leydig cells produce testosterone, which in turn produces most of the male pubertal changes. Most of the increasing bulk of testicular tissue is spermatogenic tissue (primarily Sertoli and Leydig cells). Sperm can be detected in the morning urine of most boys after the first year of pubertal changes, and occasionally earlier. On average, potential fertility in boys is reached at 13 years old, but full fertility will not be gained until 14–16 years of age.
During puberty, a male's scrotum will become larger and begin to dangle or hang below the body as opposed to being up tight. This is to accommodate the testicles to hang lower whereby the testicles need a certain temperature to be fertile and produce sperm. This is colloquially referred to as "balls dropping".
Morning wood and random or unwanted erections
Erections during sleep or when waking up are medically known as nocturnal penile tumescence and colloquially referred to as morning wood. The penis can regularly get erect during sleep and men or boys often wake-up with an erection. Once a boy reaches his teenage years, erections occur much more frequently due to puberty. Erections can occur spontaneously at any time of day, and if clothed may cause a bulge or "hump". This can be disguised or hidden by wearing close-fitting underwear, a long shirt and baggier clothes. Erections are common for male children and infants, and can even occur before birth. Spontaneous erections are also known as involuntary or unwanted erections and are normal. Such erections can be embarrassing if they happen in public, such as a classroom or living room.
During puberty, if not before, the tip and opening of a boy's foreskin becomes wider, progressively allowing for retraction down the shaft of the penis and behind the glans, which ultimately should be possible without pain or difficulty. The membrane that bonds the inner surface of the foreskin with the glans disintegrates and releases the foreskin to separate from the glans. The foreskin then gradually becomes retractable.
Research by Øster (1968) found that with the onset and continuation of puberty, the proportion of boys able to pull-back their foreskins increased. At ages 12–13, Øster found that only 60% of boys were able to retract their foreskins; this increased to 85% by ages 14–15, and 95% by 16–17. He also found that 1% of those unable to fully retract experienced phimosis at ages 14–17, the remainder were partially able to. The findings were supported by further research by Kayaba et al (1996) on a sample of over 600 boys, and Ishikawa and Kawakita (2004) found that by age 15, 77% of their sample of boys could retract their foreskins.
Once a boy is able to retract his foreskin, penile hygiene should become an important feature of his routine body care. Although the American Academy of Pediatrics states there is "little evidence to affirm the association between circumcision status and optimal penile hygiene", various studies suggest that boys be educated about the role of hygiene, including retracting the foreskin while urinating and rinsing under it and around the glans at each bathing opportunity. Regular washing under the foreskin was found by Krueger and Osborn (1986) to reduce the risk of numerous penile disorders.
Pubic hair often appears on a boy shortly after the genitalia begin to grow. The pubic hairs are usually first visible at the dorsal (abdominal) base of the penis. The first few hairs are described as stage 2. Stage 3 is usually reached within another 6–12 months, when the hairs are too many to count. By stage 4, the pubic hairs densely fill the "pubic triangle." Stage 5 refers to the spread of pubic hair to the thighs and upward towards the navel as part of the developing abdominal hair.
Body and facial hair
In the months and years following the appearance of pubic hair, other areas of skin that respond to androgens may develop androgenic hair. The usual sequence is: underarm (axillary) hair, perianal hair, upper lip hair, sideburn (preauricular) hair, periareolar hair, and the beard area. As with most human biological processes, this specific order may vary among some individuals. Arm, leg, chest, abdominal, and back hair become heavier more gradually. There is a large range in amount of body hair among adult men, and significant differences in timing and quantity of hair growth among different racial groups. Facial hair is often present in late adolescence, but may not appear until significantly later. Facial hair will continue to get coarser, darker and thicker for another 2–4 years after puberty. Some men do not develop full facial hair for up to 10 years after the completion of puberty. Chest hair may appear during puberty or years after. Not all men have chest hair.
Voice change and Adam's apple
Under the influence of androgens, the voice box, or larynx, grows in both sexes. This growth is far more prominent in boys, causing the male voice to drop and deepen, sometimes abruptly but rarely "overnight," about one octave, because the longer and thicker vocal folds have a lower fundamental frequency. Before puberty, the larynx of boys and girls is about equally small. Occasionally, voice change is accompanied by unsteadiness of vocalization in the early stages of untrained voices. Most of the voice change happens during stage 3-4 of male puberty around the time of peak growth. Full adult pitch is attained at an average age of 15 years. It usually precedes the development of significant facial hair by several months to years.
Male musculature and body shape
By the end of puberty, adult men have heavier bones and nearly twice as much skeletal muscle. Some of the bone growth (e.g. shoulder width and jaw) is disproportionately greater, resulting in noticeably different male and female skeletal shapes. The average adult male has about 150% of the lean body mass of an average female, and about 50% of the body fat.
This muscle develops mainly during the later stages of puberty, and muscle growth can continue even after boys are biologically adult. The peak of the so-called "strength spurt", the rate of muscle growth, is attained about one year after a male experiences his peak growth rate.
Often, the fat pads of the male breast tissue and the male nipples will develop during puberty; sometimes, especially in one breast, this becomes more apparent and is termed gynecomastia. It is usually not a permanent phenomenon.
Body odor and acne
Rising levels of androgens can change the fatty acid composition of perspiration, resulting in a more "adult" body odor. As in girls, another androgen effect is increased secretion of oil (sebum) from the skin and the resultant variable amounts of acne. Acne can not be prevented or diminished easily, but it typically fully diminishes at the end of puberty. However, it is not unusual for a fully grown adult to suffer the occasional bout of acne, though it is normally less severe than in adolescents. Some may desire using prescription topical creams or ointments to keep acne from getting worse, or even oral medication, due to the fact that acne is emotionally difficult and can cause scarring.
Physical changes in girls
The first physical sign of puberty in girls is usually a firm, tender lump under the center of the areola of one or both breasts, occurring on average at about 10.5 years of age. This is referred to as thelarche. By the widely used Tanner staging of puberty, this is stage 2 of breast development (stage 1 is a flat, prepubertal breast). Within six to 12 months, the swelling has clearly begun in both sides, softened, and can be felt and seen extending beyond the edges of the areolae. This is stage 3 of breast development. By another 12 months (stage 4), the breasts are approaching mature size and shape, with areolae and nipples forming a secondary mound. In most young women, this mound disappears into the contour of the mature breast (stage 5), although there is so much variation in sizes and shapes of adult breasts that stages 4 and 5 are not always separately identifiable.
Pubic hair is often the second noticeable change in puberty, usually within a few months of thelarche. It is referred to as pubarche. The pubic hairs are usually visible first along the labia. The first few hairs are described as Tanner stage 2. Stage 3 is usually reached within another 6–12 months, when the hairs are too numerous to count and appear on the pubic mound as well. By stage 4, the pubic hairs densely fill the "pubic triangle." Stage 5 refers to spread of pubic hair to the thighs and sometimes as abdominal hair upward towards the navel. In about 15% of girls, the earliest pubic hair appears before breast development begins.
Vagina, uterus, ovaries
Perineal skin keratinizes due to effect of estrogen increasing its resistance to infection. The mucosal surface of the vagina also changes in response to increasing levels of estrogen, becoming thicker and duller pink in color (in contrast to the brighter red of the prepubertal vaginal mucosa). Mucosa changes into a multilayered structure with superficial layer of squamous cells. Estrogen increase glycogen content in vaginal epithelium, which in future plays important part in maintaining vaginal pH. Whitish secretions (physiologic leukorrhea) are a normal effect of estrogen as well. In the two years following thelarche, the uterus, ovaries, and the follicles in the ovaries increase in size. The ovaries usually contain small follicular cysts visible by ultrasound. Before puberty, uterine body to cervix ratio is 1:1; which increases to 2:1 or 3:1 after completion of pubertal period.
Menstruation and fertility
The first menstrual bleeding is referred to as menarche, and typically occurs about two years after thelarche. The average age of menarche is 12.5 in the United States. Most American girls experience their first period at 11, 12 or 13, but some experience it earlier than their 11th birthday and others after their 14th birthday. In fact, anytime between 8 and 16 is normal. In Canada, the average age of menarche is 12.72, and in the United Kingdom it is 12.9. The time between menstrual periods (menses) is not always regular in the first two years after menarche. Ovulation is necessary for fertility, but may or may not accompany the earliest menses. In postmenarchal girls, about 80% of the cycles were anovulatory in the first year after menarche, 50% in the third year and 10% in the sixth year. Initiation of ovulation after menarche is not inevitable. A high proportion of girls with continued irregularity in the menstrual cycle several years from menarche will continue to have prolonged irregularity and anovulation, and are at higher risk for reduced fertility.
Body shape, fat distribution, and body composition
During this period, also in response to rising levels of estrogen, the lower half of the pelvis and thus hips widen (providing a larger birth canal). Fat tissue increases to a greater percentage of the body composition than in males, especially in the typical female distribution of breasts, hips, buttocks, thighs, upper arms, and pubis. Progressive differences in fat distribution as well as sex differences in local skeletal growth contribute to the typical female body shape by the end of puberty. On average, at 10 years, girls have 6% more body fat than boys.
Body odor and acne
Rising levels of androgens can change the fatty acid composition of perspiration, resulting in a more "adult" body odor. This often precedes thelarche and pubarche by one or more years. Another androgen effect is increased secretion of oil (sebum) from the skin. This change increases the susceptibility to acne, a skin condition that is characteristic of puberty. Acne varies greatly in its severity.
Other effects of hormonal changes
Estradiol in girls causes thickening of lips and oral mucosa as well as further development of the vulva. In the vulva and vagina estradiol causes thickening (stratification) of the skin, growth of the myopethelial layer and smooth muscle of the vagina. Typically estradiol will also cause pronounced growth of the labia minora and to a lesser degree of the labia majora.
Estradiol is also responsible for the increased production of pheomelanin, resulting in the characteristic red color of the lips, labia minora and sometimes labia majora. Estradiol together with other ovarian steroids also cause the darker coloration of the areola.
Testosterone will cause an enlargement of the clitoris and possibly has important effects on the growth and maturation of the vestibular bulbs, corpus cavernosum of the clitoris and urethral sponge.
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Timing of the onset of puberty
The definition of the onset of puberty may depend on perspective (e.g., hormonal versus physical) and purpose (establishing population normal standards, clinical care of early or late pubescent individuals, etc.). A common definition for the onset of puberty is physical changes to a person's body. These physical changes are the first visible signs of neural, hormonal, and gonadal function changes.
The age at which puberty begins varies between individuals; usually, puberty begins between 10 and 13 years of age. The age at which puberty begins is affected by both genetic factors and by environmental factors such as nutritional state and social circumstances. An example of social circumstances is the Vandenbergh effect; a juvenile female who has significant interaction with adult males will enter puberty earlier than juvenile females who are not socially overexposed to adult males.
The average age at which puberty begins may be affected by race as well. For example, the average age of menarche in various populations surveyed has ranged from 12 to 18 years. The earliest average onset of puberty is for African-American girls and the latest average onset for high altitude subsistence populations in Asia. However, much of the higher age averages reflect nutritional limitations more than genetic differences and can change within a few generations with a substantial change in diet. The median age of menarche for a population may be an index of the proportion of undernourished girls in the population, and the width of the spread may reflect unevenness of wealth and food distribution in a population.
Researchers have identified an earlier age of the onset of puberty. However, they have based their conclusions on a comparison of data from 1999 with data from 1969. In the earlier example, the sample population was based on a small sample of white girls (200, from Britain). The later study identified as puberty as occurring in 48% of African-American girls by age nine, and 12% of white girls by that age.
One possible cause of a delay in the onset of puberty past the age 14 in girls and 15 in boys is Kallmann syndrome, a form of hypogonadotropic hypogonadism (HH). Kallmann syndrome is also associated with a lack of sense of smell (anosmia). Kallmann syndrome and other forms of HH affect both men and women. It is caused by a failure in HPG axis at puberty which results in low or zero gonadotropin (LH and FSH) levels with the subsequent result of a failure to commence or complete puberty, secondary hypogonadism and infertility.
The average age at which the onset of puberty occurs has dropped significantly since the 1840s. This was dubbed 'the secular trend' by J.M. Tanner. In every decade from 1840 to 1950 there was a drop of four months in the average age of menarche among Western European females. In Norway, girls born in 1840 had their menarche at an average age of 17 years. In France, the average in 1840 was 15.3 years. In England, the average in 1840 was 16.5 years. In Japan the decline happened later and was then more rapid: from 1945 to 1975 in Japan there was a drop of 11 months per decade.
A 2006 study in Denmark found that puberty, as evidenced by breast development, started at an average age of 9 years and 10 months, a year earlier than when a similar study was done in 1991. Scientists believe the phenomenon could be linked to obesity or exposure to chemicals in the food chain, and is putting girls at greater long-term risk of breast cancer.
Genetic influence and environmental factors
Various studies have found direct genetic effects to account for at least 46% of the variation of timing of puberty in well-nourished populations. The genetic association of timing is strongest between mothers and daughters. The specific genes affecting timing are not yet known. Among the candidates is an androgen receptor gene.
Researchers have hypothesized that early puberty onset may be caused by certain hair care products containing estrogen or placenta, and by certain chemicals, namely phthalates, which are used in many cosmetics, toys, and plastic food containers.
If genetic factors account for half of the variation of pubertal timing, environment factors are clearly important as well. One of the first observed environmental effects is that puberty occurs later in children raised at higher altitudes. The most important of the environmental influences is clearly nutrition, but a number of others have been identified, all which affect timing of female puberty and menarche more clearly than male puberty.
Hormones and steroids
There is theoretical concern, and animal evidence, that environmental hormones and chemicals may affect aspects of prenatal or postnatal sexual development in humans. Large amounts of incompletely metabolized estrogens and progestagens from pharmaceutical products are excreted into the sewage systems of large cities, and are sometimes detectable in the environment. Sex steroids are sometimes used in cattle farming but have been banned in chicken meat production for 40 years. Although agricultural laws regulate use to minimize accidental human consumption, the rules are largely self-enforced in the United States. Significant exposure of a child to hormones or other substances that activate estrogen or androgen receptors could produce some or all of the changes of puberty.
Harder to detect as an influence on puberty are the more diffusely distributed environmental chemicals like PCBs (polychlorinated biphenyl), which can bind and trigger estrogen receptors.
More obvious degrees of partial puberty from direct exposure of young children to small but significant amounts of pharmaceutical sex steroids from exposure at home may be detected during medical evaluation for precocious puberty, but mild effects and the other potential exposures outlined above would not.
Bisphenol A (BPA) is a chemical used to make plastics, and is frequently used to make baby bottles, water bottles, sports equipment, medical devices, and as a coating in food and beverage cans. Scientists are concerned about BPA's behavioral effects on fetuses, infants, and children at current exposure levels because it can affect the prostate gland, mammary gland, and lead to early puberty in girls. BPA mimics and interferes with the action of estrogen—an important reproduction and development regulator. It leaches out of plastic into liquids and foods, and the Centers for Disease Control and Prevention (CDC) found measurable amounts of BPA in the bodies of more than 90 percent of the U.S. population studied. The highest estimated daily intakes of BPA occur in infants and children. Many plastic baby bottles contain BPA, and BPA is more likely to leach out of plastic when its temperature is increased, as when one warms a baby bottle or warms up food in the microwave.
Nutritional factors are the strongest and most obvious environmental factors affecting timing of puberty. Girls are especially sensitive to nutritional regulation because they must contribute all of the nutritional support to a growing fetus. Surplus calories (beyond growth and activity requirements) are reflected in the amount of body fat, which signals to the brain the availability of resources for initiation of puberty and fertility.
Much evidence suggests that for most of the last few centuries, nutritional differences accounted for majority of variation of pubertal timing in different populations, and even among social classes in the same population. Recent worldwide increased consumption of animal protein, other changes in nutrition, and increases in childhood obesity have resulted in falling ages of puberty, mainly in those populations with the higher previous ages. In many populations the amount of variation attributable to nutrition is shrinking.
Although available dietary energy (simple calories) is the most important dietary influence on timing of puberty, quality of the diet plays a role as well. Lower protein intakes and higher dietary fiber intakes, as occur with typical vegetarian diets, are associated with later onset and slower progression of female puberty.
Obesity influence and exercise
Scientific researchers have linked early obesity with an earlier onset of puberty in girls. They have cited obesity as a cause of breast development before nine years and menarche before twelve years. Early puberty in girls can be a harbinger of later health problems.
The average level of daily physical activity has also been shown to affect timing of puberty, especially in females. A high level of exercise, whether for athletic or body image purposes, or for daily subsistence, reduces energy calories available for reproduction and slows puberty. The exercise effect is often amplified by a lower body fat mass and cholesterol.
Physical and mental illness
Chronic diseases can delay puberty in both boys and girls. Those that involve chronic inflammation or interfere with nutrition have the strongest effect. In the western world, inflammatory bowel disease and tuberculosis have been notorious for such an effect in the last century, while in areas of the underdeveloped world, chronic parasite infections are widespread.
Mental illnesses occur in puberty. The brain undergoes significant development by hormones which can contribute to mood disorders such as Major depressive disorder, bipolar disorder, dysthymia and schizophrenia. Girls aged between 15 and 19 make up 40% of anorexia nervosa cases.
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Some of the least understood environmental influences on timing of puberty are social and psychological. In comparison with the effects of genetics, nutrition, and general health, social influences are small, shifting timing by a few months rather than years. Mechanisms of these social effects are unknown, though a variety of physiological processes, including pheromones, have been suggested based on animal research.
The most important part of a child's psychosocial environment is the family, and most of the social influence research has investigated features of family structure and function in relation to earlier or later female puberty. Most of the studies have reported that menarche may occur a few months earlier in girls in high-stress households, whose fathers are absent during their early childhood, who have a stepfather in the home, who are subjected to prolonged sexual abuse in childhood, or who are adopted from a developing country at a young age. Conversely, menarche may be slightly later when a girl grows up in a large family with a biological father present.
More extreme degrees of environmental stress, such as wartime refugee status with threat to physical survival, have been found to be associated with delay of maturation, an effect that may be compounded by dietary inadequacy.
Most of these reported social effects are small and our understanding is incomplete. Most of these "effects" are statistical associations revealed by epidemiologic surveys. Statistical associations are not necessarily causal, and a variety of covariables and alternative explanations can be imagined. Effects of such small size can never be confirmed or refuted for any individual child. Furthermore, interpretations of the data are politically controversial because of the ease with which this type of research can be used for political advocacy. Accusations of bias based on political agenda sometimes accompany scientific criticism.
Another limitation of the social research is that nearly all of it has concerned girls, partly because female puberty requires greater physiologic resources and partly because it involves a unique event (menarche) that makes survey research into female puberty much simpler than male. More detail is provided in the menarche article.
Variations of sequence
The sequence of events of pubertal development can occasionally vary. For example, in about 15% of boys and girls, pubarche (the first pubic hairs) can precede, respectively, gonadarche and thelarche by a few months. Rarely, menarche can occur before other signs of puberty in a few girls. These variations deserve medical evaluation because they can occasionally signal a disease.
In a general sense, the conclusion of puberty is reproductive maturity. Criteria for defining the conclusion may differ for different purposes: attainment of the ability to reproduce, achievement of maximal adult height, maximal gonadal size, or adult sex hormone levels. Maximal adult height is achieved at an average age of 15 years for an average girl and 18 years for an average boy. Potential fertility (sometimes termed nubility) usually precedes completion of growth by 1–2 years in girls and 3–4 years in boys. Stage 5 typically represents maximal gonadal growth and adult hormone levels.
The endocrine reproductive system consists of the hypothalamus, the pituitary, the gonads, and the adrenal glands, with input and regulation from many other body systems. True puberty is often termed "central puberty" because it begins as a process of the central nervous system. A simple description of hormonal puberty is as follows:
- The brain's hypothalamus begins to release pulses of GnRH.
- Cells in the anterior pituitary respond by secreting LH and FSH into the circulation.
- The ovaries or testes respond to the rising amounts of LH and FSH by growing and beginning to produce estradiol and testosterone.
- Rising levels of estradiol and testosterone produce the body changes of female and male puberty.
The onset of this neurohormonal process may precede the first visible body changes by 1–2 years.
Components of the endocrine reproductive system
The arcuate nucleus of the hypothalamus is the driver of the reproductive system. It has neurons which generate and release pulses of GnRH into the portal venous system of the pituitary gland. The arcuate nucleus is affected and controlled by neuronal input from other areas of the brain and hormonal input from the gonads, adipose tissue and a variety of other systems.
The pituitary gland responds to the pulsed GnRH signals by releasing LH and FSH into the blood of the general circulation, also in a pulsatile pattern.
- Neurokinin B (a tachykinin peptide) and kisspeptin (a neuropeptide), both present in the same hypothalamic neurons, are critical parts of the control system that switches on the release of GnRH at the start of puberty.
- GnRH (gonadotropin-releasing hormone) is a peptide hormone released from the hypothalamus which stimulates gonadotrope cells of the anterior pituitary.
- LH (luteinizing hormone) is a larger protein hormone secreted into the general circulation by gonadotrope cells of the anterior pituitary gland. The main target cells of LH are the Leydig cells of testes and the theca cells of the ovaries. LH secretion changes more dramatically with the initiation of puberty than FSH, as LH levels increase about 25-fold with the onset of puberty, compared with the 2.5-fold increase of FSH.
- FSH (follicle stimulating hormone) is another protein hormone secreted into the general circulation by the gonadotrope cells of the anterior pituitary. The main target cells of FSH are the ovarian follicles and the Sertoli cells and spermatogenic tissue of the testes.
- Testosterone is a steroid hormone produced primarily by the Leydig cells of the testes, and in lesser amounts by the theca cells of the ovaries and the adrenal cortex. Testosterone is the primary mammalian androgen and the "original" anabolic steroid. It acts on androgen receptors in responsive tissue throughout the body.
- Estradiol is a steroid hormone produced by aromatization of testosterone. Estradiol is the principal human estrogen and acts on estrogen receptors throughout the body. The largest amounts of estradiol are produced by the granulosa cells of the ovaries, but lesser amounts are derived from testicular and adrenal testosterone.
- Adrenal androgens are steroids produced by the zona reticulosa of the adrenal cortex in both sexes. The major adrenal androgens are dehydroepiandrosterone, androstenedione (which are precursors of testosterone), and dehydroepiandrosterone sulfate which is present in large amounts in the blood. Adrenal androgens contribute to the androgenic events of early puberty in girls.
- IGF1 (insulin-like growth factor 1) rises substantially during puberty in response to rising levels of growth hormone and may be the principal mediator of the pubertal growth spurt.
- Leptin is a protein hormone produced by adipose tissue. Its primary target organ is the hypothalamus. The leptin level seems to provide the brain a rough indicator of adipose mass for purposes of regulation of appetite and energy metabolism. It also plays a permissive role in female puberty, which usually will not proceed until an adequate body mass has been achieved.
The endocrine reproductive system becomes functional by the end of the first trimester of fetal life. The testes and ovaries become briefly inactive around the time of birth but resume hormonal activity until several months after birth, when incompletely understood mechanisms in the brain begin to suppress the activity of the arcuate nucleus. This has been referred to as maturation of the prepubertal "gonadostat," which becomes sensitive to negative feedback by sex steroids. The period of hormonal activity until several months after birth, followed by suppression of activity, may correspond to the period of infant sexuality, followed by a latency stage, which Sigmund Freud described.
Gonadotropin and sex steroid levels fall to low levels (nearly undetectable by current clinical assays) for approximately another 8 to 10 years of childhood. Evidence is accumulating that the reproductive system is not totally inactive during the childhood years. Subtle increases in gonadotropin pulses occur, and ovarian follicles surrounding germ cells (future eggs) double in number.
Normal puberty is initiated in the hypothalamus, with de-inhibition of the pulse generator in the arcuate nucleus. This inhibition of the arcuate nucleus is an ongoing active suppression by other areas of the brain. The signal and mechanism releasing the arcuate nucleus from inhibition have been the subject of investigation for decades and remain incompletely understood. Leptin levels rise throughout childhood and play a part in allowing the arcuate nucleus to resume operation. If the childhood inhibition of the arcuate nucleus is interrupted prematurely by injury to the brain, it may resume pulsatile gonadotropin release and puberty will begin at an early age.
Neurons of the arcuate nucleus secrete gonadotropin releasing hormone (GnRH) into the blood of the pituitary portal system. An American physiologist, Ernst Knobil, found that the GnRH signals from the hypothalamus induce pulsed secretion of LH (and to a lesser degree, FSH) at roughly 1-2 hour intervals. The LH pulses are the consequence of pulsatile GnRH secretion by the arcuate nucleus that, in turn, is the result of an oscillator or signal generator in the central nervous system ("GnRH pulse generator"). In the years preceding physical puberty, Robert M. Boyar discovered that the gonadotropin pulses occur only during sleep, but as puberty progresses they can be detected during the day. By the end of puberty, there is little day-night difference in the amplitude and frequency of gonadotropin pulses.
Some investigators have attributed the onset of puberty to a resonance of oscillators in the brain. By this mechanism, the gonadotropin pulses that occur primarily at night just before puberty represent beats.
An array of "autoamplification processes" increases the production of all of the pubertal hormones of the hypothalamus, pituitary, and gonads.
Regulation of adrenarche and its relationship to maturation of the hypothalamic-gonadal axis is not fully understood, and some evidence suggests it is a parallel but largely independent process coincident with or even preceding central puberty. Rising levels of adrenal androgens (termed adrenarche) can usually be detected between 6 and 11 years of age, even before the increasing gonadotropin pulses of hypothalamic puberty. Adrenal androgens contribute to the development of pubic hair (pubarche), adult body odor, and other androgenic changes in both sexes. The primary clinical significance of the distinction between adrenarche and gonadarche is that pubic hair and body odor changes by themselves do not prove that central puberty is underway for an individual child.
Hormonal changes in boys
|This section does not cite any references or sources. (November 2011)|
Early stages of male hypothalamic maturation seem to be very similar to the early stages of female puberty, though occurring about 1–2 years later.
LH stimulates the Leydig cells of the testes to make testosterone and blood levels begin to rise. For much of puberty, nighttime levels of testosterone are higher than daytime. Regularity of frequency and amplitude of gonadotropin pulses seems to be less necessary for progression of male than female puberty.
However, a significant portion of testosterone in adolescent boys is converted to estradiol. Estradiol mediates the growth spurt, bone maturation, and epiphyseal closure in boys just as in girls. Estradiol also induces at least modest development of breast tissue (gynecomastia) in a large proportion of boys. Boys who develop mild gynecomastia or even developing swellings under nipples during puberty are told the effects are temporary in some male teenagers due to high levels of estradiol.
Another hormonal change in males takes place during the teenage years for most young men. At this point in a male's life the testosterone levels slowly rise, and most of the effects are mediated through the androgen receptors by way of conversion dihydrotestosterone in target organs (especially that of the bowels).
Hormonal changes in girls
|This section does not cite any references or sources. (November 2011)|
As the amplitude of LH pulses increases, the theca cells of the ovaries begin to produce testosterone and smaller amounts of progesterone. Much of the testosterone moves into nearby cells called granulosa cells. Smaller increases of FSH induce an increase in the aromatase activity of these granulosa cells, which converts most of the testosterone to estradiol for secretion into the circulation. The remaining testosterone, together with adrenal androgens is responsible for the typical androgenic changes of female puberty: pubic hair, other androgenic hair as outlined above, body odor, acne. The bioactivity of testosterone is to a large degree limited by SHBG which in turn is mainly controlled by estradiol and prolactin levels (estradiol stimulates, prolactin decreases SHBG synthesis).
Rising levels of estradiol produce the characteristic estrogenic body changes of female puberty: growth spurt, acceleration of bone maturation and closure, breast growth, increased fat composition, growth of the uterus, increased thickness of the endometrium and the vaginal mucosa, and widening of the lower pelvis.
As the estradiol levels gradually rise and the other autoamplification processes occur, a point of maturation is reached when the feedback sensitivity of the hypothalamic "gonadostat" becomes positive. This attainment of positive feedback is the hallmark of female sexual maturity, as it allows the mid cycle LH surge necessary for ovulation.
Growth hormone levels rise steadily throughout puberty. IGF1 levels rise and then decline as puberty ends. Growth finishes and adult height is attained as the estradiol levels complete closure of the epiphyses.
- adrenarche (approximately age 7)
- gonadarche (approximately age 8)
- thelarche (approximately age 11 in females)
- pubarche (approximately age 12)
- menarche (approximately age 12.5 in females)
- spermarche (in males)
- Adolescent sexuality
- Child sexuality
- Delayed puberty
- Precocious puberty
- Secondary sex characteristic
- Kallmann syndrome
- "When Is Puberty Too Early?". Duke University Hospital. Retrieved October 10, 2012.
- (Chumlea, 1982).
- "For girls, puberty begins around 10 or 11 years of age and ends around age 16. Boys enter puberty later than girls-usually around 12 years of age-and it lasts until around age 16 or 17." "Teenage Growth & Development: 11 to 14 Years". pamf.org.
- "Teenage Growth & Development: 15 to 17 Years". pamf.org.
- "Puberty and adolescence". Retrieved July 5, 2009.
- Marshall (1986), p. 176–7
- (Tanner, 1990).
- Anderson SE, Dallal GE, Must A (April 2003). "Relative weight and race influence average age at menarche: results from two nationally representative surveys of US girls studied 25 years apart". Pediatrics 111 (4 Pt 1): 844–50. doi:10.1542/peds.111.4.844. PMID 12671122.
- Al-Sahab B, Ardern CI, Hamadeh MJ, Tamim H (2010). "Age at menarche in Canada: results from the National Longitudinal Survey of Children & Youth". BMC Public Health (BMC Public Health) 10: 736. doi:10.1186/1471-2458-10-736. PMC 3001737. PMID 21110899.
- Hamilton-Fairley, Diana. Obstetrics and Gynaecology (Second ed.). Blackwell Publishing.
- (Jorgensen & Keiding 1991).
- Alleyne, Richard (2010-06-13). "Girls now reaching puberty before 10 - a year sooner than 20 years ago". The Daily Telegraph (London).
- Guillette EA, Conard C, Lares F, Aguilar MG, McLachlan J, Guillette LJ (March 2006). "Altered breast development in young girls from an agricultural environment". Environ. Health Perspect. 114 (3): 471–5. PMC 1392245. PMID 16507474.
- Buck Louis GM, Gray LE, Marcus M, Ojeda SR, Pescovitz OH, Witchel SF, Sippell W, Abbott DH, Soto A, Tyl RW, Bourguignon JP, Skakkebaek NE, Swan SH, Golub MS, Wabitsch M, Toppari J, Euling SY (February 2008). "Environmental factors and puberty timing: expert panel research needs". Pediatrics. 121 Suppl 3: S192–207. doi:10.1542/peds.1813E. PMID 18245512.
- Mouritsen A, Aksglaede L, Sørensen K, Mogensen SS, Leffers H, Main KM, Frederiksen H, Andersson AM, Skakkebaek NE, Juul A (April 2010). "Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty". Int. J. Androl. 33 (2): 346–59. doi:10.1111/j.1365-2605.2010.01051.x. PMID 20487042.
- The Oxford Dictionary of English Etymology, C.T. Onions ed. Oxford University Press 1996 p. 720.
- Garn, SM. Physical growth and development. In: Friedman SB, Fisher M, Schonberg SK., editors. Comprehensive Adolescent Health Care. St Louis: Quality Medical Publishing; 1992. Retrieved on 2009-02-20
- Abbassi, V (1998). "Growth and normal puberty.". Pediatrics 102 (2 Pt 3): 507–513. PMID 9685454.
- MacGillivray, MH; Morishima, A; Conte, F; Grumbach, M; Smith, EP (1998). "Pediatric endocrinology update: an overview. The essential roles of estrogens in pubertal growth, epiphyseal fusion and bone turnover: lessons from mutations in the genes for aromatase and the estrogen receptor.". Hormone research. 49 Suppl 1: 2–8. PMID 9554463.
- Plant, T.M. (2001). "Leptin, growth hormone, and the onset of primate puberty.". The Journal of Clinical Endocrinology and Metabolism 86 (1): 458–460. doi:10.1210/jc.86.1.459. PMID 11232044.
- Essential Reproduction, M Johnson, Blackwell Publishers, 6th Rev Ed edition (29 Jun 2007)
- "Precocious Puberty". MERCK. May 16, 2008.
- Meister, B; Håkansson, ML (2001). "Leptin receptors in hypothalamus and circumventricular organs.". Clinical and experimental pharmacology & physiology 28 (7): 610–617. doi:10.1046/j.1440-1681.2001.03493.x. PMID 11458889.
- Clayton, PE; Trueman, JA (2000). "Leptin and puberty.". Archives of Disease in Childhood 83 (1): 1–4. doi:10.1136/adc.83.1.1. PMC 1718397. PMID 10868988.
- Topaloglu, AK; Reiman, F; Guclu, M; Yalin, AS; Kotan, LD; Porter, KM; Serin, A; Mungan, NO et al. (2009). "TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction.". Nature Genetics 41 (3): 354–358. doi:10.1038/ng.306. PMID 19079066.
- Styne (2002), p. 598
- Jones, Kenneth W. (2006). Smith's Recognizable Patterns of Human Malformation. St. Louis, Mo: Elsevier Saunders. ISBN 0-7216-0615-6.
- Marshall (1986), p. 180.
- "Normal development of the prepuce: Birth through age 18". Retrieved November 14, 2011.
- Øster, Jakob (April 1968). "Further Fate of the Foreskin Incidence of Preputial Adhesions, Phimosis, and Smegma among Danish Schoolboys". Archives of Disease in Childhood (Department of Paediatrics, Central Hospital, Randers, Denmark) 43: 200–202. doi:10.1136/adc.43.228.200. PMC 2019851. PMID 5689532. Retrieved November 14, 2011.
- Kayaba, Hiroyuki (November 1996). "Analysis of Shape and Retractability of the Prepuce in 603 Japanese Boys". Hiromi Tamura, Seiichi Kitajima, Yoshiyuki Fujiwara, Tetsuo Kato and Tetsuro Kato. Journal of Urology (American Urological Association, Inc.) 156 (5): 1813–1815. doi:10.1016/S0022-5347(01)65544-7. PMID 8863623.
- Ishikawa, E.; Kawakita, M. (2004). "Preputial development in Japanese boys". Hinyokika Kiyo 50 (5): 305–8.
- "Circumcision Policy Statement". Pediatrics 103 (3): 686–93. 1999. doi:10.1542/peds.103.3.686. PMID 10049981.
- Krueger, H; Osborn, L (1986). "Effects of hygiene among the uncircumcised.". The Journal of family practice 22 (4): 353–5. PMID 3958682.
- "Getting The Facts: Puberty". ppwr. Retrieved 2009-02-20.
- "The No-Hair Scare". PBS. Retrieved 2009-02-20.
- "The structure of the larynx". Encyclopædia Britannica. Retrieved 2009-02-20.
- Marshall (1986), p. 187
- Marshall (1986), p. 188
- Tanner, JM; Davies, PS (1985). "Clinical longitudinal standards for height and height velocity for North American children.". The Journal of pediatrics 107 (3): 317–329. doi:10.1016/S0022-3476(85)80501-1. PMID 3875704.
- Gordon (2005), p. 151
- Marshall (1986), p. 186–7
- Rosenfield (2002), p. 462
- Siegel, MJ; Surratt, JT (1992). "Pediatric gynecologic imaging.". Obstetrics and gynecology clinics of North America 19 (1): 103–127. PMID 1584537.
- Apter, D (1980). "Serum steroids and pituitary hormones in female puberty: a partly longitudinal study.". Clinical endocrinology 12 (2): 107–120. doi:10.1111/j.1365-2265.1980.tb02125.x. PMID 6249519.
- Marshall (1986), p. 196-7
- Southam, AL; Richart, RM (1966). "The prognosis for adolescents with menstrual abnormalities.". American journal of obstetrics and gynecology 94 (5): 637–645. PMID 5906589.
- "Hips widen during female puberty". Columbia.
- Gungor (2002), pages 699-700
- Rosenfield (2002)[page needed]
- Kalloo, N. B.; Gearhart, J. P.; Barrack, E. R. (1993). "Sexually dimorphic expression of estrogen receptors, but not of androgen receptors in human fetal external genitalia". The Journal of clinical endocrinology and metabolism 77 (3): 692–698. PMID 8370691.
- Andersson, K. -E.; Wein, A. J. (2004). "Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence". Pharmacological Reviews 56 (4): 581–631. doi:10.1124/pr.56.4.4. PMID 15602011.
- Robinson, D.; Cardozo, L. (2011). "Estrogens and the lower urinary tract". Neurourology and Urodynamics 30 (5): 754–757. doi:10.1002/nau.21106. PMID 21661025.
- "Puberty and adolescence". MedlinePlus. Retrieved 2010-07-30.
- Kaplowitz, PB; Slora, EJ; Wasserman, RC; Pedlow, SE; Herman-Giddens, ME (2001). "Earlier onset of puberty in girls: relation to increased body mass index and race.". Pediatrics 108 (2): 347–53. doi:10.1542/peds.108.2.347. PMID 11483799.
- Nelson RJ. 2005. Introduction to Behavioral Endocrinology. Sinauer Associates: Massachusetts. p357.
- Zuckerman, Diana (May 2009). "Early Puberty in Girls". National Research Center for Women and Families. Retrieved 2010-07-13.
- Mitchell AL, Dwyer A, Pitteloud N, Quinton R (2011). "Genetic basis and variable phenotypic expression of Kallmann syndrome: towards a unifying theory.". Trends Endocrinol Metab. 22 (7): 249–58. PMID 21511493.
- Oxford Endocrinology Library. Testosterone Deficiency in Men. 2008. ISBN 978-0199545131 Editor: Hugh Jones. Chapter 9. Puberty & Fertility.
- Finley, Harry. "Average age at menarche in various cultures". Museum of Menstruation and Women s Health. Retrieved 2007-08-02.
- Whincup, P H; Gilg, JA; Odoki, K; Taylor, SJ; Cook, DG (2001). "Age of menarche in contemporary British teenagers: survey of girls born between 1982 and 1986". BMJ 322 (7294): 1095–6. doi:10.1136/bmj.322.7294.1095. PMC 31261. PMID 11337438.
- "Girls maturing slightly earlier". BBC News. 2001-05-03. Retrieved 2007-08-02.
- Rogers, Lois (2010-06-13). "Girls now begin puberty aged 9". The Times (London).
- Ge, Xiaojia; Natsuaki, Misaki N.; Neiderhiser, Jenae M.; Reiss, David (2007). "Genetic and Environmental Influences on Pubertal Timing: Results From Two National Sibling Studies". Journal of Research on Adolescence 17: 767. doi:10.1111/j.1532-7795.2007.00546.x.
- Mustanski, BS; Viken, RJ; Kaprio, J; Pulkkinen, L; Rose, RJ (2004). "Genetic and environmental influences on pubertal development: longitudinal data from Finnish twins at ages 11 and 14.". Developmental psychology 40 (6): 1188–1198. doi:10.1037/0012-1622.214.171.1248. PMID 15535766.
- Treloar, SA; Martin, NG (1990). "Age at menarche as a fitness trait: nonadditive genetic variance detected in a large twin sample.". American Journal of Human Genetics 47 (1): 137–148. PMC 1683767. PMID 2349942.
- Kaprio, J; Rimpelä, A; Winter, T; Viken, RJ; Rimpelä, M; Rose, RJ (1995). "Common genetic influences on BMI and age at menarche.". Human biology; an international record of research 67 (5): 739–753. PMID 8543288.
- Comings, DE; Muhleman, D; Johnson, JP; MacMurray, JP (2002). "Parent-daughter transmission of the androgen receptor gene as an explanation of the effect of father absence on age of menarche.". Child Development 73 (4): 1046–1051. doi:10.1111/1467-8624.00456. PMID 12146732.
- Diana Zuckerman, "When Little Girls Become Women: Early Onset of Puberty in Girls" (This article appeared in The Ribbon, a newsletter of the Cornell University Program on Breast Cancer and Environmental Risk Factors in New York States (BCERF), Vol 6, No. 1, Winter 2001.) http://www.center4research.org/2010/04/girls-to-women/
- , T., Dumanoski, D. and Myers, J.P. Our Stolen Future, 1996, Plume: New York.[page needed]
- "Are Bisphenol A (BPA) Plastic Products Safe for Infants and Children?".
- McKenna, Phil (2007-03-05). "Childhood obesity brings early puberty for girls". New Scientist. Archived from the original on 2008-04-19. Retrieved 2010-05-22.
- Molly, M. Ginty, "US Girls' Early Puberty Attracts Research Flurry", Women's eNews
- Bulik, CM; Reba, L; Siega-riz, AM; Reichborn-kjennerud, T (2005). "Anorexia nervosa: definition, epidemiology, and cycle of risk.". The International Journal of Eating Disorders. 37 Suppl: S2–9; discussion S20–1. doi:10.1002/eat.20107. PMID 15852310.
- Topaloglu, A Kemal; Reimann, Frank; Guclu, Metin; Yalin, Ayse Serap; Kotan, L Damla; Porter, Keith M; Serin, Ayse; Mungan, Neslihan O et al. (2008). "TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction". Nature Genetics 41 (3): 354–8. doi:10.1038/ng.306. PMID 19079066. Lay summary – e! Science News (2008-12-11).
- Lehrer, S (1984). "Modern correlates of Freudian psychology. Infant sexuality and the unconscious.". The American Journal of Medicine 77 (6): 977–80. doi:10.1016/0002-9343(84)90172-4. PMID 6507468.
- Neill, J. D. (2001). "In Memoriam: Ernst Knobil (1926-2000)". Endocrine Reviews 22 (6): 721–3. doi:10.1210/er.22.6.721. PMID 11739328.
- Boyar, R; Finkelstein, J; Roffwarg, H; Kapen, S; Weitzman, E; Hellman, L (1972). "Synchronization of augmented luteinizing hormone secretion with sleep during puberty.". The New England Journal of Medicine 287 (12): 582–586. doi:10.1056/NEJM197209212871203. PMID 4341276.
- Sizonenko, PC; Aubert, ML (1986). "Neuroendocrine changes characteristic of sexual maturation.". Journal of neural transmission. Supplementum 21: 159–181. PMID 3462329.
- Rivest, RW (1991). "Sexual maturation in female rats: hereditary, developmental and environmental aspects.". Experientia 47 (10): 1027–1038. PMID 1936201.
- Yellon, SM; Newman, SW (1991). "A developmental study of the gonadotropin-releasing hormone neuronal system during sexual maturation in the male Djungarian hamster.". Biology of Reproduction 45 (3): 440–446. doi:10.1095/biolreprod45.3.440. PMID 1782292.
- Armstrong, SM; Redman, JR (1991). "Melatonin: a chronobiotic with anti-aging properties?". Medical hypotheses 34 (4): 300–309. doi:10.1016/0306-9877(91)90046-2. PMID 1865836.
- Lehrer, S (1983). "Puberty and resonance: a hypothesis.". The Mount Sinai journal of medicine, New York 50 (1): 39–43. PMID 6601758.
- Lehrer, S (1986). "Rats on 22.5-hr light:dark cycles have vaginal opening earlier than rats on 26-hr light:dark cycles.". Journal of Pineal Research 3 (4): 375–378. doi:10.1111/j.1600-079X.1986.tb00759.x. PMID 3783418.
- Vilaplana, J; Madrid, JA; Sánchez-vázquez, J; Campuzano, A; Cambras, T; Díez-noguera, A (1995). "Influence of period length of light/dark cycles on the body weight and food intake of young rats.". Physiology & behavior 58 (1): 9–13. doi:10.1016/0031-9384(95)00021-A. PMID 7667433.
- Gordon, Catharine M.; Laufer, MR (2005). "Chapter 4: Physiology of puberty". In Emans SJH, Goldstein DP, Laufer, MR, eds. Pediatric and Adolescent Gynecology (5th ed.). Philadelphia: Lippincott, Williams & Wilkins. pp. 120–155. ISBN 0-7817-4493-8.
- Gungor, Neslihan; Arslanian SA (2002). "Chapter 21: Nutritional disorders: integration of energy metabolism and its disorders in childhood". In Sperling, MA ed. Pediatric Endocrinology (2nd ed.). Philadelphia: Saunders. pp. 689–724. ISBN 0-7216-9539-6.
- Marshall, William A.; Tanner, JM (1986). "Chapter 8: Puberty". In Falkner F, Tanner JM, eds. Human Growth: A Comprehensive Treatise (2nd ed.). New York: Plenum Press. pp. 171–209. ISBN 0-306-41952-1.
- Rosenfield, Robert L. (2002). "Chapter 16: Female puberty and its disorders". In Sperling, MA ed. Pediatric Endocrinology (2nd ed.). Philadelphia: Saunders. pp. 455–518. ISBN 0-7216-9539-6.
- Styne, Dennis M. (2002). "Chapter 18: The testes: disorders of sexual differentiation and puberty in the male". In Sperling, MA ed. Pediatric Endocrinology (2nd ed.). Philadelphia: Saunders. pp. 565–628. ISBN 0-7216-9539-6.
- Colburn, T., Dumanoski, D. and Myers, J.P. Our Stolen Future, 1996, Plume: New York.
- Ducros, A. and Pasquet, P. "Evolution de l'âge d'apparition des premières règles (ménarche) en France". Biométrie Humaine (1978), 13, 35–43.
- Herman-giddens, ME; Slora, EJ; Wasserman, RC; Bourdony, CJ; Bhapkar, MV; Koch, GG; Hasemeier, CM (1997). "Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network.". Pediatrics 99 (4): 505–12. doi:10.1542/peds.99.4.505. PMID 9093289. Newer data suggesting that lower age thresholds for evaluation should be used.
- Plant TM, Lee PA, eds. The Neurobiology of Puberty. Bristol: Society for Endocrinology, 1995. Proceedings of the latest (4th) International Conference on the Control of the Onset of Puberty, containing summaries of current theories of physiological control, as well as GnRH analog treatment.
- Tanner, JM; Davies, PS (1985). "Clinical longitudinal standards for height and height velocity for North American children.". The Journal of pediatrics 107 (3): 317–29. doi:10.1016/S0022-3476(85)80501-1. PMID 3875704. Highly useful growth charts with integrated standards for stages of puberty.
- Sizonenko, PC. Role of sex steroids during development—integration. in Bourguignon, Jean Pierre & Tony M. Plant. The Onset of Puberty in Perspective: Proceedings of the 5th International Conference on the Control of the Onset of Puberty, Held in Liège, Belgium, 26–28 September 1999. Elsevier. Amsterdam & New York 2000. ISBN 0-444-50296-3. pp 299–306.
|Wikisource has the text of the 1911 Encyclopædia Britannica article Puberty.|
- Support for teens
- NIH guide to puberty and adolescence
- Growing Up Sexually: A World Atlas
- Pictures and detailed information about breast development during puberty
- Research shows how evolution explains age of puberty, ScienceDaily, December 1, 2005.
- Gluckman, PD; Hanson, MA (2006). "Evolution, development and timing of puberty.". Trends in endocrinology and metabolism: TEM 17 (1): 7–12. doi:10.1016/j.tem.2005.11.006. PMID 16311040.
- Terasawa, E; Fernandez, DL (2001). "Neurobiological mechanisms of the onset of puberty in primates.". Endocrine Reviews 22 (1): 111–51. doi:10.1210/er.22.1.111. PMID 11159818.
- Puberty in girls: interactive animation of Tanner stages
- Puberty in boys: interactive animation of Tanner stages