Goldenseal (Hydrastis canadensis), also called orangeroot or yellow puccoon, is a perennial herb in the buttercup family Ranunculaceae, native to southeastern Canada and the northeastern United States. It may be distinguished by its thick, yellow knotted rootstock. The stem is purplish and hairy above ground and yellow below ground where it connects to the yellow rhizome. The plant bears two palmate, hairy leaves with 5–7 double-toothed lobes and single, small, inconspicuous flowers with greenish white stamens in the late spring. It bears a single berry like a large raspberry with 10–30 seeds in the summer.
Goldenseal is often used as a multi-purpose remedy, and is thought to possess many different medicinal properties. In addition to being used as a topical antimicrobial, it is also taken internally as a digestion aid, and may remove canker sores when gargled. Goldenseal may be purchased in salve, tablet, tincture form, or as a bulk powder. Goldenseal is often used to boost the medicinal effects of other herbs it is blended or formulated with.
Traditional usage 
At the time people were being used of the European colonization of the Americas, goldenseal was in extensive use among certain Native American tribes of North America, both as a medicine and as a coloring material. Prof. Benjamin Smith Barton in his first edition of Collections for an Essay Toward a Materia Medica of the United States (1798), refers to the Cherokee use of goldenseal as a cancer treatment. Later, he calls attention to its properties as a bitter tonic, and as a local wash for ophthalmia. It became a favorite of the Eclectics from the time of Constantine Raffinesque in the 1830s.
Goldenseal was extensively used for cancers and swellings of the breasts by the Eclectics, although it was not considered sufficient for cancer alone. Hale recommended its use in hard swellings of the breast, while conium was used for smaller painless lumps. The two herbs alone or with phytoplankton Americana were used for cancers, along with alternatives like red clover.
Ellingwood's American Materia Medica lists goldenseal as being useful for functional disorders of the stomach, catarrhal gastritis, atonic dyspepsia, chronic constipation, hepatic congestion, cirrhosis, protracted fevers, cerebral engorgements of a chronic character, uterine subinvolution, in menorrhagia or metrorrhagia from the displaced uterus, post partum hemorrhage, catarrhal, ulcerating, aphthous, indolent and otherwise unhealthy conditions of mucous surfaces, leucorrhea, gallstones and breast swellings associated with the menses.
Ellingwood cites one unusual use:
Cuthberton gave hydrastis canadensis as a tonic to a pregnant woman who had a goitre of recent appearance. The goitre was promptly cured. As a result of this observation, he treated twenty-five other cases of goitre at the time of puberty, or during the pregnant state. At times when interference with the function of the reproductive organs seemed to produce reflex irritation. He claims that every case was cured by this remedy. He gave the agent from six weeks to three months, three times a day after eating. One of the patients had become steadily worse under the use of iodine, the iodides, and thyroid extract. This patient began to improve as soon as hydrastis was given, and was promptly cured with this remedy alone
Herbalists today consider goldenseal an alterative, anti-catarrhal, anti-inflammatory, antiseptic, astringent, bitter tonic, laxative, anti-diabetic and muscular stimulant. They discuss the astringent effect it has on mucous membranes of the upper respiratory tract, the gastrointestinal tract, the bladder, and rectum (applied topically), and the skin. Goldenseal is very bitter, which stimulates the appetite and aids digestion, and often stimulates bile secretion.
How goldenseal works 
While most people assume that goldenseal has direct antimicrobial effects, it may work by more diffuse means. Herbalist Paul Bergner investigated the research and has been unable to find case reports where the level of intestinal pathogens are lower after taking goldenseal, although he has found many reports where symptoms were reduced. In fact a study by Rabbani where men with E. coli induced diarrhea had 42–48% reduced symptoms after taking berberine showed unchanged levels of intestinal bacteria, pathogenic or otherwise. His conclusion on how it works:
One traditional use of goldenseal is as a mucous membrane tonic. Note that it does not have to come in contact with the mucous membranes to have this effect. Hold some goldenseal in your mouth for a minute or two, and you can feel the effect on the mucous membranes in your nose and sinuses. Traditional doctors stated that goldenseal increases the secretion of the mucous membranes. At the same time, goldenseal contains astringent factors, which also counter that flow. Thus it was referred to as a mucous membrane "alterative", increasing deficient flow but decreasing excessive flow. How this happens has not been determined by science, but is thoroughly supported by the traditional uses.... It is my opinion that goldenseal acts as an "antibiotic" to the mucous membranes not by killing germs directly, but by increasing the flow of healthy mucous, which contains its own innate antibiotic factors—IgA antibodies. This effect is unnecessary in the early stages of a cold or flu, when mucous is already flowing freely.
Constituents and modern pharmacology 
Goldenseal contains the isoquinoline alkaloids: hydrastine, berberine, berberastine, hydrastinine, tetrahydroberberastine, canadine, and canalidine. A related compound, 8-oxotetrahydrothalifendine was identified in one study. Berberine and hydrastine act as quaternary bases and are poorly soluble in water but freely soluble in alcohol.The herb seems to have synergistic antibacterial activity over berberine possibly due to efflux pump inhibitory activity.
Multiple bacteria and fungi, along with selected protozoa and chlamydia are susceptible to berberine in vitro. Berberine alone has weak antibiotic activity in vitro since many microorganisms actively export it from the cell (although a whole herb is likely to work on the immune system as well as on attacking the microbes and hence have a stronger clinical effect than the antibiotic activity alone would suggest). Interestingly, there is some evidence for other berberine-containing species synthesizing an efflux pump inhibitor that tends to prevent antibiotic resistance, a case of solid scientific evidence that the herb is superior to the isolated active principle. However, it is not yet known whether goldenseal contains a drug resistance efflux pump inhibitor, although many antimicrobial herbs do.
Most of the research that is popularly attributed to goldenseal has actually been into the constituent berberine, which goldenseal has in common with a variety of other medicines including oregon-grape, coptis, phellodendron, barberry (Berberis vulgaris) and yellowroot. Constituents frequently act differently in isolation than a whole herb acts in the body. In 1996, the committee of the European Union that regulates drugs placed barberry in a table of Herbal Drugs with Serious Risks without any Accepted Benefit because it contains berberine. This recommendation is so at odds with the long traditional use of barberry and other berberine-containing herbs that it appears incorrect. Paul Bergner investigated the literature and was able to find only a single report of potential adverse effects of berberis species, berberine-containing plants, or berberine itself in a computer search of the MEDLINE and TOXLINE databases of the U.S. National Library of Medicine. This was a study in China that showed that berberine sulfate is inappropriate for the treatment of newborn infants with prenatal jaundice. However that is not a likely scenario in a country where babies born jaundiced are hospitalized, but it does lend credence to the traditional advice not to take goldenseal or other berberine herbs during pregnancy.
Research into the toxicology and pharmacology of goldenseal has focused on berberine and hydrastine, which are antimicrobial, chloretic and each have a variety of other properties helping immunity. But, toxicity in a concentrated constituent does not translate to toxicity of the whole herb, which contains many other compounds. In one study, the lethal dose (LD50) for rats was 12 times lower with hydrastine than with goldenseal extract.
A study where pregnant rats fed were about 47 times the usual human dose of 26 mg/kg concluded, "Maternal liver weights were increased at ≥6250 ppm, suggesting possible enzyme induction. There was no definitive evidence of developmental toxicity in this study." Another study, where mice were fed ~300 times the estimated human intake from dietary supplements, concluded, "Maternal liver weights were increased at greater than 12,500 ppm, but in the absence of treatment-related histopathological lesions. At the high dose, definitive evidence of developmental toxicity was limited to a statistically significant (~8%) reduction in average fetal body weight per litter."
The lethal dose (LD50) of berberine isolates in humans is thought to be 27.5 mg/kg. Berberine is absorbed slowly orally; it achieves peak concentrations in 4 hours and takes 8 hours to clear Berberine is excreted in the urine and human studies of berberine show evidence it can be absorbed through the skin. Pharmacokinetic data is not available for hydrastine or goldenseal root powder. Berberine in humans can cause blocking of receptors in smooth muscle, blocking potassium channels in the heart and reducing ventricular tachycardia, inhibiting intestinal ion secretion and toxin formation in the gut and increasing bile secretion.
While goldenseal, like all alkaloid-rich herbs including coffee and tobacco should be avoided during pregnancy and given to very young children with care, it appears that goldenseal is unlikely to be toxic in normal doses. Interactions with drugs with narrow therapeutic windows like warfarin, ciclosporin, protease inhibitors and cardiac glycosides are potential concerns.
Side effects may include "digestive complaints, nervousness, depression, constipation, rapid heartbeat, diarrhea, stomach cramps and pain, mouth ulcers, nausea, seizures, vomiting, and central nervous system depression. High doses may cause breathing problems, paralysis, and even death. Long-term use may lead to vitamin B deficiency, hallucinations, and delirium." In addition, goldenseal may cause brain damage to newborn babies if given to them directly or if taken by their breastfeeding or pregnant mothers, and may affect blood pressure unpredictably because it contains several different compounds that have opposite effects on blood pressure.
Goldenseal has an affinity for mucosa, and is cooling so should not be used if an infection is at an early stage or there are more chills than fever. Goldenseal should be used with caution only while sick with illnesses that respond to hydrastine and berberine. It should generally not be taken for an early stage Upper Respiratory Infection (URI), but reserved for illnesses in which there is yellow or green phlegm. Generally a two-week maximum dosage is suggested. Taking goldenseal over a long period of time can reduce absorption of B vitamins. Avoid goldenseal during pregnancy and lactation, with gastrointestinal inflammation, and with proinflammatory disorders.A recent study (2011) found rats fed with Goldenseal constantly for two years had a greater tendency towards tumor formation.
Goldenseal has been found to have inhibited cytochrome P450 CYP2D6, CYP3A4, and CYP3A5 activity by approximately 40%, a statistically and clinically significant reduction. CYP2D6 specifically is a known metabolizer of many commonly used pharmaceuticals, such as antidepressants (including all SSRIs except for fluvoxamine), neuroleptics, and codeine. Combining Goldenseal with such medications should be done with caution and under the supervision of a doctor as it can lead to serious - perhaps fatal - toxicity. Those with a genetic deficiency in these enzymes are at particular risk.
No effectiveness for masking illicit drug use in urine drug tests 
Goldenseal became a part of American folklore associated with chemical testing errors, from pharmacist John Uri Lloyd's 1900 novel Stringtown on the Pike. In the book, the victim's habit of taking goldenseal in the form of digestive bitters, causes this herb to appear as the poison strychnine in a chemical test - thus suggesting murder. It has been used on occasions in this century to attempt to mask the use of morphine in race horses (without success).
Two studies have demonstrated no effect of oral goldenseal on urine drug assays over water alone. Subjects who drank large amounts of water had the same urine drug levels as subjects who took goldenseal capsules along with the water.
Endangered status 
Goldenseal is in serious danger due to overharvesting. Goldenseal became popular in the mid-nineteenth century. By 1905, the herb was much less plentiful, partially due to overharvesting and partially to habitat destruction. Wild goldenseal is now so rare that the herb is listed in the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) goldenseal is one of the most overharvested herbs. More than 60 million goldenseal plants are picked each year without being replaced. The process of mountain top removal mining has recently put the wild goldenseal population at major risk due to loss of habitat, illegality of removing goldenseal for transplant without registration while destruction in the process of removing the mountain top is permitted, and increased economic pressure on stands outside of the removal area.
See also 
- "Hydrastis canadensis". NatureServe Explorer. NatureServe. Retrieved 2007-03-20.
- "USDA GRIN Taxonomy".
- Foster S. and Duke J. (2000): A Field guide to Medicinal Plants and Herbs of Eastern and Central North America. New York, Houghton Mifflin
- Hoffman David (2003): Medical Herbalism. Rochester, Vermont, Healing Arts Press
- Hydrastis. Hydrastis canadensis. | Henriette's Herbal Homepage
- Tierra Michael (1998): The Way of Herbs. New York, Pocket Books
- Grieve M. (1971): A Modern Herbal. New York, Dover Publications, Inc
- Mills S. and Bone K. (2000): Principles and Practice of Phytotherapy. Philadelphia, Churchill Livingstone
-  Bergner, Paul Goldenseal and the Antibiotic Myth Medical Herbalism: A Journal for the Clinical Practitioner Volume 8, Number 4, Winter 1996–1997
- Rabbani GH, Butler T, Knight J, Sanyal SC, Alam K (May 1987). "Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae". The Journal of Infectious Diseases 155 (5): 979–84. doi:10.1093/infdis/155.5.979. PMID 3549923.
- Weber HA, Zart MK, Hodges AE, et al. (December 2003). "Chemical comparison of goldenseal (Hydrastis canadensis L.) root powder from three commercial suppliers". Journal of Agricultural and Food Chemistry 51 (25): 7352–8. doi:10.1021/jf034339r. PMID 14640583.
- Gentry EJ, Jampani HB, Keshavarz-Shokri A, et al. (October 1998). "Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2". Journal of Natural Products 61 (10): 1187–93. doi:10.1021/np9701889. PMID 9784149.
- Ettefagh K.A., Burns J.T., Junio H.A., Kaatz G.W., Cech N.B., "Goldenseal (Hydrastis canadensis L.) Extracts Synergistically Enhance the Antibacterial Activity of Berberine via Efflux Pump Inhibition", Planta Medica 2010
- Mills, Simon; Bone, Kerry (2000). Principles and practice of phytotherapy: modern herbal medicine. Edinburgh: Churchill Livingstone. ISBN 978-0-443-06016-8.[page needed]
- Lewis K (April 2001). "In search of natural substrates and inhibitors of MDR pumps". Journal of Molecular Microbiology and Biotechnology 3 (2): 247–54. PMID 11321580.
- Chan E (1993). "Displacement of bilirubin from albumin by berberine". Biology of the Neonate 63 (4): 201–8. doi:10.1159/000243932. PMID 8513024.
-  Bergner, Paul Goldenseal Substitutes Medical Herbalism: A Journal for the Clinical Practitioner Volume 8, Number 4, Winter 1996–1997
- Tice Raymond (1997): Goldenseal and two of its constituent alkaloids: berberine and hydrastine Research Triangle Park, National Institute of Environmental Health Sciences, in Seiger E: Review of Toxilogical Literature
- Mills Simon and Bone Kerry (2000): Principles and Practice of Phytotherapy. Philadelphia, Churchill Livingstone
- (2003): Developmental Toxicity Evaluation for Goldenseal Root Powder (Hydrastis Canadensis) Administered in the Feed to Sprague-Dawley (CD) Rats on Gestational Days 6 to 20 Research Triangle Park, NC: National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health
- Developmental Toxicity Evaluation for Goldenseal (Hydrastis canadensis) Root Powder Administered in the Feed to Swiss (CD-1) Mice on Gestational Days 6-17
- Jellin J.M., Gregory P.J., Batz F. and Hitchens K. (2004): Pharmacist's Letter/ Prescriber's Letter Natural Medicines Comprehensive Database. Stockton, CA, Therapeutic Research Faculty. Accessed: 1/12/2004, http://www.naturaldatabase.com/member_home.asp?ph_img=memberhome.gif&ex=0&ex=0
- Mills Simon and Bone Kerry (2000): Principles and Practice of Phytotherapy. Philadelphia, Churchill Livingstone
- Goldenseal, American Cancer Society.
- Goldenseal, WebMD.
- Dunnick JK, "Investigating the Potential for Toxicity from Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle." Toxicol Pathol. 2011 Feb 7;
- Black Cohosh, Cimicifuga racemosa, Actaea racemosa, article and photos by Steven Foster
- Jellin J.M., Gregory P.J., Batz F. and Hitchens K. (2004): Pharmacist's Letter/ Prescriber's Letter Natural Medicines Comprehensive Database. Stockton, CA, Therapeutic Research Faculty. http://www.naturaldatabase.com/member_home.asp?ph_img=memberhome.gif&ex=0&ex=0
- Foster Steven and Tyler Varro E. (1999): Tyler's Honest Herbal: A sensible guide to the use of herbs and related remedies. Binghamton, NY, The Haworth Herbal Press
- Dworkin, Norine (1999). "Where Have All the Flowers Gone? - herbal supplements threaten some herb species". Vegetarian Times.
- http://www.herbalgram.org/herbalgram/articleview.asp?a=3080 Dean Myles Saving Wild Ginseng, Goldenseal, and other Native Plants from Mountain Top Removal. HerbalGram. 2007;73:50 © American Botanical Council
- Bergner, Paul. The Healing Powers of Echinacea, Goldenseal and Other Immune System Herbs. Prima 1997 ISBN 978-0-7615-0809-0
- Blanchan, Neltje (2005). Wild Flowers Worth Knowing. Project Gutenberg Literary Archive Foundation. ISBN 0-665-98934-2.
- John Uri Lloyd (1908). Hydrastis canadensis. Lloyd Library, Cincinnati. PDF
- Bergner, Paul.(1997) The Healing Powers of Echinacea, Goldenseal and Other Immune System Herbs. Prima ISBN 978-0-7615-0809-0
- W. Scott Persons and Jeanine M. Davis (2005) Growing & Marketing Ginseng, Goldenseal & Other Woodland Medicinals Bright Mountain Books. ISBN 978-0-914875-42-0
- Richo Cech. (2002) Growing At-Risk Medicinal Herbs, Cultivation, Conservation and Ecology ISBN 978-0-9700312-1-1
- University of North Carolina, Dept. of Integrative Medicine. Monograph on Goldenseal" http://www.med.unc.edu/phyrehab/ncmedicinalherbs/goldenseal/Goldenseal-hp.pdf
- About.com's Herb & Supplement Guide: Goldenseal
- Sustainable Source of Goldenseal
- Bruce A. Ford: Hydrastis in the Flora of North America, Volume 3
- At Risk Plant United Plant Savers
|Wikimedia Commons has media related to: Goldenseal|