The Joseph Campau House is a two-story house with a symmetrical three-bay façade; the exterior is faced with flush board siding on the front and clapboards on the other three sides. A porch, constructed in the 20th century, spans the front. The exterior is plain, with a pedimental window head center gabled second story window and a plain entablature board under the eaves as the only decorations.
The house is one of the oldest residences in Detroit. It was built on land that was originally part of the Joseph Campau farm, a large tract of land awarded Joseph Campau's grandfather in 1734. Joseph Campau was among Detroit's leading citizens and wealthiest landowners at the dawn of the 19th century. Although he never lived in this house, it is the only residence identified with Joseph Campau.