Mesa de Otay is a borough of the municipality of Tijuana in Baja California, Mexico.
Mesa de Otay borough is located east of the center and Zona Río; south of the U.S. border and San Diego's Otay Mesa neighborhood; west of Centenario and north of La Mesa. The Otay Mesa Port of Entry is here, as are the Tijuana International Airport, the Autonomous University of Baja California, Tijuana, the Universidad Tecnológica de Tijuana, and many maquiladoras. Main shopping centers are the Centro Comercial Otayand Plaza Americana Otay, which is located in front of Centro Comercial Otay. The area is noted as the second gastronomic hub of the city, with many restaurants.