Ovulation is the phase of a female's menstrual cycle in which a mature egg is released from the ovarian follicles into the oviduct. After ovulation, during the luteal phase, the egg will be available to be fertilized by sperm. Concomitantly, the lining of the uterus (the endometrium) is thickened to be able to receive a fertilized egg. If no conception occurs, the uterine lining as well as blood will be shed during menstruation.
Ovulation in humans 
In humans, ovulation occurs about midway through the menstrual cycle, after the follicular phase. The few days surrounding ovulation (from approximately days 10 to 18 of a 28 day cycle), constitute the most fertile phase. The time from the beginning of the last menstrual period (LMP) until ovulation is, on average, 14.6 days, but with substantial variation between women and between cycles in any single woman, with an overall 95% prediction interval of 8.2 to 20.5 days.
The process of ovulation is controlled by the hypothalamus of the brain and through the release of hormones secreted in the anterior lobe of the pituitary gland, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In the pre-ovulatory phase of the menstrual cycle, the ovarian follicle will undergo a series of transformations called cumulus expansion, which is stimulated by FSH. After this is done, a hole called the stigma will form in the follicle, and the ovum will leave the follicle through this hole. Ovulation is triggered by a spike in the amount of FSH and LH released from the pituitary gland. During the luteal (post-ovulatory) phase, the ovum will travel through the fallopian tubes toward the uterus. If fertilized by a sperm, it may implant there 6–12 days later.
Follicular phase 
The follicular phase (or proliferative phase) is the phase of the menstrual cycle during which the ovarian follicles mature. The follicular phase lasts from the beginning of menstruation to the start of ovulation.
For ovulation to be successful, the ovum must be supported by the corona radiata and cumulus oophorous granulosa cells. The latter undergo a period of proliferation and mucification known as cumulus expansion. Mucification is the secretion of a hyaluronic acid-rich cocktail that disperses and gathers the cumulus cell network in a sticky matrix around the ovum. This network stays with the ovum after ovulation and has been shown to be necessary for fertilization.
An increase in cumulus cell number causes a concomitant increase in antrum fluid volume that can swell the follicle to over 20 mm in diameter. It forms a pronounced bulge at the surface of the ovary called the blister.
Estrogen levels peak towards the end of the follicular phase, which causes a surge in levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This lasts from 24 to 36 hours, and results in the rupture of the ovarian follicles, causing the egg to be released from the ovary via the oviduct.
Through a signal transduction cascade initiated by LH, proteolytic enzymes are secreted by the follicle that degrade the follicular tissue at the site of the blister, forming a hole called the stigma. The cumulus-oocyte complex (COC) leaves the ruptured follicle and moves out into the peritoneal cavity through the stigma, where it is caught by the fimbriae at the end of the fallopian tube (also called the oviduct). After entering the oviduct, the ovum-cumulus complex is pushed along by cilia, beginning its journey toward the uterus.
By this time, the oocyte has completed meiosis I, yielding two cells: the larger secondary oocyte that contains all of the cytoplasmic material and a smaller, inactive first polar body. Meiosis II follows at once but will be arrested in the metaphase and will so remain until fertilization. The spindle apparatus of the second meiotic division appears at the time of ovulation. If no fertilization occurs, the oocyte will degenerate approximately 24 hours after ovulation.
Luteal phase 
The follicle proper has met the end of its lifespan. Without the ovum, the follicle folds inward on itself, transforming into the corpus luteum (pl. corpora lutea), a steroidogenic cluster of cells that produces estrogen and progesterone. These hormones induce the endometrial glands to begin production of the proliferative endometrium and later into secretory endometrium, the site of embryonic growth if fertilization occurs. The action of progesterone increases basal body temperature by one-quarter to one-half degree Celsius (one-half to one degree Fahrenheit). The corpus luteum continues this paracrine action for the remainder of the menstrual cycle, maintaining the endometrium, before disintegrating into scar tissue during menses.
Clinical presentation 
The start of ovulation can be detected by signs. Because the signs are not readily discernible by people other than the woman herself, humans are said to have a concealed ovulation. In many animal species there are distinctive signals indicating the period when the female is fertile. Several explanations have been proposed to explain concealed ovulation in humans.
Women near ovulation experience changes in the cervix, in mucus produced by the cervix, and in their basal body temperature. Furthermore, many women experience secondary fertility signs including Mittelschmerz (pain associated with ovulation) and a heightened sense of smell, and can sense the precise moment of ovulation.
Symptoms related to the onset of ovulation, the moment of ovulation and the body's process of beginning and ending the menstrual cycle vary in intensity with each woman but are fundamentally the same. The charting of such symptoms — primarily basal body temperature, Mittelschmerz and cervical position — is referred to as the sympto-thermal method of fertility awareness, which allow auto-diagnosis by a woman of her state of ovulation. Once training has been given by a suitable authority, fertility charts can be completed on a cycle-by-cycle basis to show ovulation. This gives the possibility of using the data to predict fertility for natural contraception and pregnancy planning.
Disorders of ovulation are classified as menstrual disorders and include oligoovulation and anovulation:
- Oligoovulation is infrequent or irregular ovulation (usually defined as cycles of ≥36 days or <8 cycles a year)
- Anovulation is absence of ovulation when it would be normally expected (in a post-menarchal, premenopausal woman). Anovulation usually manifests itself as irregularity of menstrual periods, that is, unpredictable variability of intervals, duration, or bleeding. Anovulation can also cause cessation of periods (secondary amenorrhea) or excessive bleeding (dysfunctional uterine bleeding).
- WHO group I: Hypothalamic–pituitary-gonadal axis failure
- WHO group II: Hypothalamic–pituitary-gonadal axis dysfunction. WHO group II is the most common cause of ovulatory disorders, and the most common causative member is polycystic ovary syndrome (PCOS).
- WHO group III: Ovarian failure
- WHO group IV: Hyperprolactinemia
Induction and suppression 
Induced ovulation 
Ovulation induction is a promising assisted reproductive technology for patients with conditions such as polycystic ovary syndrome (PCOS) and oligomenorrhea. It is also used in in vitro fertilization to make the follicles mature before egg retrieval. Usually, ovarian stimulation is used in conjunction with ovulation induction to stimulate the formation of multiple oocytes. Some sources include ovulation induction in the definition of ovarian stimulation.
Suppressed ovulation 
The majority of hormonal contraceptives and conception boosters focus on the ovulatory phase of the menstrual cycle because it is the most important determinant of fertility. Hormone therapy can positively or negatively interfere with ovulation and can give a sense of cycle control to the woman.
Estradiol and progesterone, taken in various forms including combined oral contraceptive pills, mimics the hormonal levels of the menstrual cycle and engage in negative feedback of folliculogenesis and ovulation.
See also 
- Ovulation Test at Duke Fertility Center. Retrieved July 2, 2011
- Young, Barbara (2006). Wheater's Functional Histology: A Text and Colour Atlas (5th ed.). Elsevier Health Sciences. p. 359. ISBN 9780443068508.
- References and further description of values are given in image page in Wikimedia Commons at Commons:Hormones estradiol, progesterone, LH and FSH during menstrual cycle.svg.
- Chaudhuri, S.K. (2007). "Natural Methods of Contraception". Practice of Fertility Control: A Comprehensive Manual, 7/e. Elsevier India. p. 49. ISBN 9788131211502.
- Allen, Denise (2004). Managing Motherhood, Managing Risk: Fertility and Danger in West Central Tanzania. University of Michigan Press. pp. 132–133. ISBN 9780472030279.
- Rosenthal, Martha (2012). Human Sexuality: From Cells to Society. Cengage Learning. p. 322. ISBN 9780618755714.
- Nichter, Mark; Nichter, Mimi (1996). "Cultural Notions of Fertility in South Asia and Their Influence on Sri Lankan Family Planning Practices". In Nichter, Mark; Nichter, Mimi. Anthropology & International Health: South Asian Case Studies. Psychology Press. pp. 8–11. ISBN 9782884491716.
- Geirsson, R. T. (1991). "Ultrasound instead of last menstrual period as the basis of gestational age assignment". Ultrasound in Obstetrics and Gynecology 1 (3): 212. doi:10.1046/j.1469-0705.1991.01030212.x. PMID 12797075. 
- Littleton, Lynna A. & Engebretson, Joan C. Maternity Nursing Care. Cengage Learning. p. 195. ISBN 9781401811921.
- Gupta, Ramesh C. (2011). Reproductive and Developmental Toxicology. Academic Press. p. 22. ISBN 9780123820334.
- Watson, Stephanie & Stacy, Kelli Miller (2010). "The Endocrine System". In McDowell, Julie. Encyclopedia of Human Body Systems. Greenwood. pp. 201–202. ISBN 9780313391750.
- Navarrete-Palacios, E; Hudson R, Reyes-Guerrero G et al. (July 2003). "Lower olfactory threshold during the ovulatory phase of the menstrual cycle.". Biological Psychology 63 (3): 269–279. doi:10.1016/S0301-0511(03)00076-0. PMID 12853171.
- Beckmann, Charles R.B., ed. (2010). Obstetrics and Gynecology. Lippincott Williams & Wilkins. pp. 306–307. ISBN 9780781788076.
- Susan B. Bullivant, Sarah A. Sellergren, Kathleen Stern, et al. (February 2004). "Women's sexual experience during the menstrual cycle: identification of the sexual phase by noninvasive measurement of luteinizing hormone". Journal of Sex Research 41 (1): 82–93 (in online article, see pp.14–15, 18–22). doi:10.1080/00224490409552216. PMID 15216427.
- Roberts S, Havlicek J, Flegr J, Hruskova M, Little A, Jones B, Perrett D, Petrie M (August 2004). "Female facial attractiveness increases during the fertile phase of the menstrual cycle". Proc Biol Sci 271 (Suppl 5:S): 270–2. doi:10.1098/rsbl.2004.0174. PMC 1810066. PMID 15503991.
- "article New Scientist, including photo (click on "Enlarge")". New Scientist. 2008-06-11.
- "article in Dutch-language newspaper Het Nieuwsblad". Het Nieuwsblad. 2008-06-12.
- "article in WebIndia.com". WebIndia.com. 2008-06-12.
- "article in BBC News". BBC. 2008-06-12.
- Page 54 in: Guillebaud, John; Enda McVeigh; Roy Homburg (2008). Oxford handbook of reproductive medicine and family planning. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-920380-6.
- Baird, D. T.; Balen, A.; Escobar-Morreale, H. F.; Evers, J. L. H.; Fauser, B. C. J. M.; Franks, S.; Glasier, A.; Homburg, R. et al. (2012). "Health and fertility in World Health Organization group 2 anovulatory women". Human Reproduction Update 18 (5): 586. doi:10.1093/humupd/dms019.
- IVF.com > Ovulation Induction Retrieved on Mars 7, 2010
Further reading 
- Baerwald AR, Adams GP, Pierson RA (July 2003). "A new model for ovarian follicular development during the human menstrual cycle". Fertil. Steril. 80 (1): 116–22. doi:10.1016/S0015-0282(03)00544-2. PMID 12849812.
- Chabbert Buffet N, Djakoure C, Maitre SC, Bouchard P (July 1998). "Regulation of the human menstrual cycle". Front Neuroendocrinol 19 (3): 151–86. doi:10.1006/frne.1998.0167. PMID 9665835.
- Fortune JE (February 1994). "Ovarian follicular growth and development in mammals". Biol. Reprod. 50 (2): 225–32. doi:10.1095/biolreprod50.2.225. PMID 8142540.
- Guraya SS, Dhanju CK (November 1992). "Mechanism of ovulation—an overview". Indian J. Exp. Biol. 30 (11): 958–67. PMID 1293040.
- Klowden, Marc J. (2009). "Oviposition Behavior". In Resh, Vincent H. & Carde, Ring T. Encyclopedia of Insects. Academic Press. ISBN 9780080920900.
- Human egg makes accidental debut on camera
- Ovulation moment caught on camera
- Ovulation Get to know your Ovulation Period