Since 2006, Aguilar has hosted Your Call, a daily public affairs radio show on NPR-affiliate KALWFM 91.7. Prior to becoming the show's host, Aguilar was a producer and guest host for the show. Aguilar also hosts the Activist Beat with Rose Aguilar, a "a weekly roundup of progressive activism that the mainstream media ignores, undercovers, or misrepresents."
Before joining KALW, Aguilar spent eight years as a reporter with CNET Radio, where she reported on technology's impact on society.
Aguilar is the author of Red Highways: A Liberal's Journey into the Heartland, which documented a six-month road trip she took to the so-called "red states" to interview people about issues and voting tendencies.
Aguilar is a contributor to the book Red State Rebels: Tales of Grassroots Resistance in the Heartland.
Aguilar sits on the board of the Women's Intercultural Network (WIN), a non-profit organization working to connect girls and women across borders. Aguilar speaks about the media, women's issues, and progressive politics on panels and at conferences. Aguilar is a member of the Native American Journalists Association, San Francisco Women on the Web and Journalism and Women Symposium, and is a vegan.