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Suppressor of cytokine signaling 7
Symbols SOCS7 ; NAP4; NCKAP4
External IDs OMIM608788 MGI2651588 HomoloGene16331 GeneCards: SOCS7 Gene
RNA expression pattern
PBB GE SOCS7 214015 at tn.png
More reference expression data
Species Human Mouse
Entrez 30837 192157
Ensembl ENSG00000174111 ENSMUSG00000038485
UniProt O14512 Q8VHQ2
RefSeq (mRNA) NM_014598 NM_138657
RefSeq (protein) NP_055413 NP_619598
Location (UCSC) Chr 17:
36.51 – 36.56 Mb
Chr 11:
97.36 – 97.4 Mb
PubMed search [1] [2]

Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.[1][2][3]

Model organisms[edit]

Model organisms have been used in the study of SOCS7 function. A conditional knockout mouse line, called Socs7tm1a(EUCOMM)Wtsi[9][10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[11][12][13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty five tests were carried out on mutant mice and one significant abnormality was observed: homozygous mutant males showed a decreased response to stress-induced hyperthermia.[7]


SOCS7 has been shown to interact with NCK1.[1]


  1. ^ a b Matuoka K, Miki H, Takahashi K, Takenawa T (Nov 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochem Biophys Res Commun 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857. 
  2. ^ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535. 
  3. ^ "Entrez Gene: SOCS7 suppressor of cytokine signaling 7". 
  4. ^ "Body temperature data for Socs7". Wellcome Trust Sanger Institute. 
  5. ^ "Salmonella infection data for Socs7". Wellcome Trust Sanger Institute. 
  6. ^ "Citrobacter infection data for Socs7". Wellcome Trust Sanger Institute. 
  7. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  8. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  9. ^ "International Knockout Mouse Consortium". 
  10. ^ "Mouse Genome Informatics". 
  11. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  12. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  13. ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  14. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]