Suppressor of cytokine signaling 1

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Suppressor of cytokine signaling 1
Identifiers
Symbols SOCS1 ; CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3
External IDs OMIM603597 MGI1354910 HomoloGene2776 GeneCards: SOCS1 Gene
RNA expression pattern
PBB GE SOCS1 210001 s at tn.png
PBB GE SOCS1 209999 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8651 12703
Ensembl ENSG00000185338 ENSMUSG00000038037
UniProt O15524 O35716
RefSeq (mRNA) NM_003745 NM_001271603
RefSeq (protein) NP_003736 NP_001258532
Location (UCSC) Chr 16:
11.35 – 11.35 Mb
Chr 16:
10.78 – 10.79 Mb
PubMed search [1] [2]

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene.[1][2] SOCS1 orthologs [3] have been identified in several mammals for which complete genome data are available.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), GM-CSF, and interferon-gamma (IFN-γ). The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival.[4]

See also[edit]

Interactions[edit]

Suppressor of cytokine signaling 1 has been shown to interact with Janus kinase 2,[5][6][7][8][9][10] Growth hormone receptor,[11] CD117,[12] IRS2,[13] Colony stimulating factor 1 receptor[14] and TEC.[15]

References[edit]

  1. ^ Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A (August 1995). "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors". EMBO J 14 (12): 2816–26. PMC 398400. PMID 7796808. 
  2. ^ Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (September 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833. 
  3. ^ "OrthoMaM phylogenetic marker: SOCS1 coding sequence". 
  4. ^ "Entrez Gene: SOCS1 suppressor of cytokine signaling 1". 
  5. ^ Yasukawa, H; Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle J N, Yoshimura A (March 1999). "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop". EMBO J. (ENGLAND) 18 (5): 1309–20. doi:10.1093/emboj/18.5.1309. ISSN 0261-4189. PMC 1171221. PMID 10064597. 
  6. ^ Dif, F; Saunier E, Demeneix B, Kelly P A, Edery M (Dec 2001). "Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor". Endocrinology (United States) 142 (12): 5286–93. doi:10.1210/en.142.12.5286. ISSN 0013-7227. PMID 11713228. 
  7. ^ Endo, T A; Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A (June 1997). "A new protein containing an SH2 domain that inhibits JAK kinases". Nature (ENGLAND) 387 (6636): 921–4. doi:10.1038/43213. ISSN 0028-0836. PMID 9202126. 
  8. ^ Pezet, A; Favre H, Kelly P A, Edery M (August 1999). "Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling". J. Biol. Chem. (UNITED STATES) 274 (35): 24497–502. doi:10.1074/jbc.274.35.24497. ISSN 0021-9258. PMID 10455112. 
  9. ^ Ungureanu, Daniela; Saharinen Pipsa, Junttila Ilkka, Hilton Douglas J, Silvennoinen Olli (May 2002). "Regulation of Jak2 through the Ubiquitin-Proteasome Pathway Involves Phosphorylation of Jak2 on Y1007 and Interaction with SOCS-1". Mol. Cell. Biol. (United States) 22 (10): 3316–26. doi:10.1128/MCB.22.10.3316-3326.2002. ISSN 0270-7306. PMC 133778. PMID 11971965. 
  10. ^ Masuhara, M; Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (October 1997). "Cloning and characterization of novel CIS family genes". Biochem. Biophys. Res. Commun. (UNITED STATES) 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. ISSN 0006-291X. PMID 9344848. 
  11. ^ Ram, P A; Waxman D J (Dec 1999). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". J. Biol. Chem. (UNITED STATES) 274 (50): 35553–61. doi:10.1074/jbc.274.50.35553. ISSN 0021-9258. PMID 10585430. 
  12. ^ De Sepulveda, P; Okkenhaug K, Rose J L, Hawley R G, Dubreuil P, Rottapel R (February 1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". EMBO J. (ENGLAND) 18 (4): 904–15. doi:10.1093/emboj/18.4.904. ISSN 0261-4189. PMC 1171183. PMID 10022833. 
  13. ^ Rui, Liangyou; Yuan Minsheng, Frantz Daniel, Shoelson Steven, White Morris F (November 2002). "SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2". J. Biol. Chem. (United States) 277 (44): 42394–8. doi:10.1074/jbc.C200444200. ISSN 0021-9258. PMID 12228220. 
  14. ^ Bourette, R P; De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G (June 2001). "Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal". J. Biol. Chem. (United States) 276 (25): 22133–9. doi:10.1074/jbc.M101878200. ISSN 0021-9258. PMID 11297560. 
  15. ^ Ohya, K i; Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H (October 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". J. Biol. Chem. (UNITED STATES) 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. ISSN 0021-9258. PMID 9341160. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.