IRF7

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Interferon regulatory factor 7
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IRF7 ; IRF-7H; IRF7A; IRF7B; IRF7C; IRF7H
External IDs OMIM605047 MGI1859212 HomoloGene128624 GeneCards: IRF7 Gene
RNA expression pattern
PBB GE IRF7 208436 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3665 54123
Ensembl ENSG00000185507 ENSMUSG00000025498
UniProt Q92985 P70434
RefSeq (mRNA) NM_001572 NM_001252600
RefSeq (protein) NP_001563 NP_001239529
Location (UCSC) Chr 11:
0.61 – 0.62 Mb
Chr 7:
141.26 – 141.27 Mb
PubMed search [1] [2]

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes.[1] Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.[2]

The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response.[3] Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models.

The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1 influenza, while susceptibility to other viral diseases such as CMV, RSV, and parainfluenza was unaffected.[4]

See also[edit]

Interactions[edit]

IRF7 has been shown to interact with IRF3.[5]

References[edit]

  1. ^ Marié I; Durbin JE and Levy DE (November 1998). "Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7". EMBO J. 17 (22): 6660–9. doi:10.1093/emboj/17.22.6660. PMC 1171011. PMID 9822609. 
  2. ^ "Entrez Gene: IRF7 interferon regulatory factor 7". 
  3. ^ Bidwell (2012). "Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape". Nature Medicine. Retrieved 23 July 2012. 
  4. ^ Jean-Laurent Casanova (2013). "Toward a Genetic Theory of Childhood Infectious Diseases". NIH. 
  5. ^ Au, W C; Yeow W S; Pitha P M (Feb 2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology (United States) 280 (2): 273–82. doi:10.1006/viro.2000.0782. ISSN 0042-6822. PMID 11162841. 

Further reading[edit]

  • Ning S*, Pagano J, Barber G. (2011. Epub ahead of print: 4/14/2011

PMID 21490621). "IRF7: activation, regulation, modification, and function. (Review).". Genes & Immunity.  Check date values in: |date= (help)

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.