IRF7

Interferon regulatory factor 7
Identifiers
Symbols	IRF7; IRF-7H; IRF7A
External IDs	OMIM: 605047 MGI: 1859212 HomoloGene: 1209 GeneCards: IRF7 Gene
Gene Ontology Molecular function • regulatory region DNA binding • sequence-specific DNA binding transcription factor activity • protein binding Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol • plasma membrane • endosome membrane Biological process • negative regulation of transcription from RNA polymerase II promoter • MyD88-independent toll-like receptor signaling pathway • transcription from RNA polymerase II promoter • Toll signaling pathway • response to virus • cytokine-mediated signaling pathway • positive regulation of interferon-alpha production • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • interspecies interaction between organisms • innate immune response • positive regulation of transcription from RNA polymerase II promoter • interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3665	54123
Ensembl	ENSG00000185507	ENSMUSG00000025498
UniProt	Q92985	P70434
RefSeq (mRNA)	NM_001572.3	NM_001252600.1
RefSeq (protein)	NP_001563.2	NP_001239529.1
Location (UCSC)	Chr 11: 0.61 – 0.62 Mb	Chr 7: 148.45 – 148.45 Mb
PubMed search	[1]	[2]

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.

See also

• Interferon regulatory factors

Interactions

IRF7 has been shown to interact with IRF3.

Further reading

Ning S*, Pagano J, Barber G. IRF7: activation, regulation, modification, and function. (Review). Genes & Immunity. 2011. Epub ahead of print: 4/14/2011 PMID 21490621

• Pitha PM, Au WC, Lowther W et al (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie 80 (8–9): 651–8. doi:10.1016/S0300-9084(99)80018-2. PMID 9865487. 
• Zhang L, Pagano JS (2002). "Structure and function of IRF-7". J. Interferon Cytokine Res. 22 (1): 95–101. doi:10.1089/107999002753452700. PMID 11846980. 
• Zhang L, Pagano JS (1997). "IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency". Mol. Cell. Biol. 17 (10): 5748–57. PMC 232423. PMID 9315633. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232423. 
• Wathelet MG, Lin CH, Parekh BS et al (1998). "Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo". Mol. Cell 1 (4): 507–18. doi:10.1016/S1097-2765(00)80051-9. PMID 9660935. 
• Au WC, Moore PA, LaFleur DW et al (1998). "Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes". J. Biol. Chem. 273 (44): 29210–7. doi:10.1074/jbc.273.44.29210. PMID 9786932. 
• Lu R, Au WC, Yeow WS et al (2000). "Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon snd silencing by hypermethylation". J. Biol. Chem. 275 (41): 31805–12. doi:10.1074/jbc.M005288200. PMID 10924517. 
• Paris MJ, Williams BR (2001). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics 69 (2): 196–202. doi:10.1006/geno.2000.6339. PMID 11031102. 
• Marié I, Smith E, Prakash A, Levy DE (2000). "Phosphorylation-Induced Dimerization of Interferon Regulatory Factor 7 Unmasks DNA Binding and a Bipartite Transactivation Domain". Mol. Cell. Biol. 20 (23): 8803–14. doi:10.1128/MCB.20.23.8803-8814.2000. PMC 86519. PMID 11073981. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86519. 
• Smith EJ, Marié I, Prakash A et al (2001). "IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein". J. Biol. Chem. 276 (12): 8951–7. doi:10.1074/jbc.M008717200. PMID 11124948. 
• Au WC, Yeow WS, Pitha PM (2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology 280 (2): 273–82. doi:10.1006/viro.2000.0782. PMID 11162841. 
• Lu R, Moore PA, Pitha PM (2002). "Stimulation of IRF-7 gene expression by tumor necrosis factor alpha: requirement for NFkappa B transcription factor and gene accessibility". J. Biol. Chem. 277 (19): 16592–8. doi:10.1074/jbc.M111440200. PMID 11877397. 
• Morin P, Bragança J, Bandu MT et al (2002). "Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription". J. Mol. Biol. 316 (5): 1009–22. doi:10.1006/jmbi.2001.5401. PMID 11884139. 
• Caillaud A, Prakash A, Smith E et al (2003). "Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding". J. Biol. Chem. 277 (51): 49417–21. doi:10.1074/jbc.M207484200. PMID 12374802. 
• Izmailova E, Bertley FM, Huang Q et al (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. 
• Yang H, Lin CH, Ma G et al (2003). "Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators". J. Biol. Chem. 278 (18): 15495–504. doi:10.1074/jbc.M212940200. PMID 12604599. 
• Ning S, Hahn AM, Huye LE, Pagano JS (2003). "Interferon Regulatory Factor 7 Regulates Expression of Epstein-Barr Virus Latent Membrane Protein 1: a Regulatory Circuit". J. Virol. 77 (17): 9359–68. doi:10.1128/JVI.77.17.9359-9368.2003. PMC 187426. PMID 12915551. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187426. 
• Fitzgerald KA, Rowe DC, Barnes BJ et al (2003). "LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF". J. Exp. Med. 198 (7): 1043–55. doi:10.1084/jem.20031023. PMC 2194210. PMID 14517278. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2194210. 
• Lin R, Noyce RS, Collins SE et al (2004). "The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated Genes". J. Virol. 78 (4): 1675–84. doi:10.1128/JVI.78.4.1675-1684.2004. PMC 369457. PMID 14747533. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=369457. 

External links

• MeSH IRF7+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.