STAT2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Signal transducer and activator of transcription 2, 113kDa
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols STAT2 ; ISGF-3; P113; STAT113
External IDs OMIM600556 MGI103039 HomoloGene3952 GeneCards: STAT2 Gene
RNA expression pattern
PBB GE STAT2 205170 at tn.png
PBB GE STAT2 217199 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6773 20847
Ensembl ENSG00000170581 ENSMUSG00000040033
UniProt P52630 Q9QXJ2
RefSeq (mRNA) NM_005419 NM_019963
RefSeq (protein) NP_005410 NP_064347
Location (UCSC) Chr 12:
56.74 – 56.75 Mb
Chr 10:
128.27 – 128.29 Mb
PubMed search [1] [2]

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene.[1][2]

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.[2]

Interactions[edit]

STAT2 has been shown to interact with MED14,[3] CREB-binding protein,[4] SMARCA4,[5] STAT1,[6][7][8] IFNAR2,[9][10] IFNAR1[9][11][12] and ISGF3G.[13][14]

References[edit]

  1. ^ Yan R, Qureshi S, Zhong Z, Wen Z, Darnell JE Jr (Apr 1995). "The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2". Nucleic Acids Res 23 (3): 459–63. doi:10.1093/nar/23.3.459. PMC 306697. PMID 7885841. 
  2. ^ a b "Entrez Gene: STAT2 signal transducer and activator of transcription 2, 113kDa". 
  3. ^ Lau, Joe F; Nusinzon Inna; Burakov Darya; Freedman Leonard P; Horvath Curt M (Jan 2003). "Role of metazoan mediator proteins in interferon-responsive transcription". Mol. Cell. Biol. (United States) 23 (2): 620–8. doi:10.1128/MCB.23.2.620-628.2003. ISSN 0270-7306. PMC 151539. PMID 12509459. 
  4. ^ Bhattacharya, S; Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston D M (Sep 1996). "Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha". Nature (ENGLAND) 383 (6598): 344–7. doi:10.1038/383344a0. ISSN 0028-0836. PMID 8848048. 
  5. ^ Huang, Mei; Qian Feng; Hu Yuanyu; Ang Chengeng; Li Zhong; Wen Zilong (Oct 2002). "Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes". Nat. Cell Biol. (England) 4 (10): 774–81. doi:10.1038/ncb855. ISSN 1465-7392. PMID 12244326. 
  6. ^ Li, X; Leung S; Qureshi S; Darnell J E; Stark G R (Mar 1996). "Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha". J. Biol. Chem. (UNITED STATES) 271 (10): 5790–4. doi:10.1074/jbc.271.10.5790. ISSN 0021-9258. PMID 8621447. 
  7. ^ Dumler, I; Kopmann A; Wagner K; Mayboroda O A; Jerke U; Dietz R; Haller H; Gulba D C (Aug 1999). "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells". J. Biol. Chem. (UNITED STATES) 274 (34): 24059–65. doi:10.1074/jbc.274.34.24059. ISSN 0021-9258. PMID 10446176. 
  8. ^ Fagerlund, Riku; Mélen Krister; Kinnunen Leena; Julkunen Ilkka (Aug 2002). "Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5". J. Biol. Chem. (United States) 277 (33): 30072–8. doi:10.1074/jbc.M202943200. ISSN 0021-9258. PMID 12048190. 
  9. ^ a b Li, X; Leung S; Kerr I M; Stark G R (Apr 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. (UNITED STATES) 17 (4): 2048–56. ISSN 0270-7306. PMC 232052. PMID 9121453. 
  10. ^ Nguyen, Vinh-Phúc; Saleh Abu Z M; Arch Allison E; Yan Hai; Piazza Flavia; Kim John; Krolewski John J (Mar 2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". J. Biol. Chem. (United States) 277 (12): 9713–21. doi:10.1074/jbc.M111161200. ISSN 0021-9258. PMID 11786546. 
  11. ^ Uddin, S; Chamdin A; Platanias L C (Oct 1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor". J. Biol. Chem. (UNITED STATES) 270 (42): 24627–30. doi:10.1074/jbc.270.42.24627. ISSN 0021-9258. PMID 7559568. 
  12. ^ Yan, H; Krishnan K; Greenlund A C; Gupta S; Lim J T; Schreiber R D; Schindler C W; Krolewski J J (Mar 1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein". EMBO J. (ENGLAND) 15 (5): 1064–74. ISSN 0261-4189. PMC 450004. PMID 8605876. 
  13. ^ Horvath, C M; Stark G R; Kerr I M; Darnell J E (Dec 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. (UNITED STATES) 16 (12): 6957–64. ISSN 0270-7306. PMC 231699. PMID 8943351. 
  14. ^ Martinez-Moczygemba, M; Gutch M J; French D L; Reich N C (Aug 1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". J. Biol. Chem. (UNITED STATES) 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. ISSN 0021-9258. PMID 9242679. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.