Trimethadione

Trimethadione
Clinical data
Trade names	Tridione
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	X;
Routes of; administration	Oral
ATC code	N03AC02 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	High
Metabolism	Demethylated to dimethadione
Elimination half-life	12–24 hours (trimethadione); 6–13 days (dimethadione)
Excretion	Renal
Identifiers
	IUPAC name 3,5,5-trimethyl-1,3-oxazolidine-2,4-dione;
CAS Number	127-48-0 ;
PubChem CID	5576;
IUPHAR/BPS	7316;
DrugBank	DB00347 ;
ChemSpider	5374 ;
UNII	R7GV3H6FQ4;
KEGG	D00392 ;
ChEMBL	ChEMBL695 ;
CompTox Dashboard (EPA)	DTXSID9021396 ;
ECHA InfoCard	100.004.406
Chemical and physical data
Formula	C6H9NO3
Molar mass	143.141 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1N(C(=O)OC1(C)C)C;
	InChI InChI=1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3 ; Key:IRYJRGCIQBGHIV-UHFFFAOYSA-N ;
	(verify)

Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.

Fetal trimethadione syndrome

If administered during pregnancy, fetal trimethadione syndrome may result causing facial dysmorphism (short upturned nose, slanted eyebrows), cardiac defects, intrauterine growth restriction (IUGR), and mental retardation. The fetal loss rate while using trimethadione has been reported to be as high as 87%.^[1]

References

^ Teratology and Drug Use During Pregnancy Retrieved January 2007

External links

MedlinePlus DrugInfo medmaster-a601127
Diseases Database (DDB): 30479

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[1] Teratology and Drug Use During Pregnancy Retrieved January 2007

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