|Classification and external resources|
Photograph of patient's knee showing multiple xanthoma tuberosum. Kumar et al. Cases Journal 2008
|ICD-10||E78.2 (ILDS E78.280), K13.4|
A xanthoma (pl. xanthomas or xanthomata) (condition: xanthomatosis), from Greek xanthos, ξανθος, "yellow", is a deposition of yellowish cholesterol-rich material in tendons or other body parts in various disease states. They are cutaneous manifestations of lipidosis in which there is an accumulation of lipids in large foam cells within the skin.
They are associated with hyperlipidemias, both primary and secondary types.
Palmar xanthomata and tuboeruptive xanthomata (over knees and elbows) occur in Type III hyperlipidaemia
A xanthelasma is a sharply demarcated yellowish collection of cholesterol underneath the skin, usually on or around the eyelids. Strictly, a xanthelasma is a distinct condition, only being called a xanthoma when becoming larger and nodular, assuming tumorous proportions. Still, it is often classified simply as a subtype of xanthoma.
Xanthoma tuberosum (also known as tuberous xanthoma) is characterized by xanthomas located over the joints.:530
Xanthoma tendinosum (also tendon xanthoma or tendinous xanthoma) is clinically characterized by papules and nodules found in the tendons of the hands, feet, and achilles.:531 Also associated with familial hypercholesterolemia (FH).
Palmar xanthoma is clinically characterized by yellowish plaques that involve the palms and flexural surfaces of the fingers.:531 Plane xanthomas are characterised by yellowish to orange, flat macules or slightly elevated plaques, often with a central white area which may be localised or generalised. They often arise in the skin folds, especially the palmar creases. They occur in hyperlipoproteinaemia type III and type IIA, and in association with biliary cirrhosis. The presence of palmar xanthomata, like the presence of tendinous xanthomata, is indicative of hypercholesterolaemia.
Tuberoeruptive xanthoma (ILDS E78.210) is clinically characterized by red papules and nodules that appear inflamed and tend to coalesce.:532 Tuberous xanthomas are considered similar, and within the same disease spectrum as eruptive xanthomas.
- James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- Shields, Carol; Shields, Jerry (2008). Eyelid, conjunctival, and orbital tumors: atlas and textbook. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-7578-7.
- thefreedictionary.com > xanthelasma Citing: The American Heritage Medical Dictionary Copyright 2007, 2004 and Mosby's Medical Dictionary, 8th edition. 2009
- Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1415–16. ISBN 1-4160-2999-0.
- Van Den Bosch, Harrie C.M.; van den Bosch, Harrie C.M. and D. Vos, Louwerens (May 28, 1998). "Achilles'-Tendon Xanthoma in Familial Hypercholesterolemia". New England Journal of Medicine 338 (22): 1591. doi:10.1056/NEJM199805283382205. PMID 9603797. Retrieved 5 April 2013.
|Look up xanthoma in Wiktionary, the free dictionary.|
- Media related to xanthoma at Wikimedia Commons
- 194641940 at GPnotebook
- MedlinePlus Encyclopedia Xanthoma