Mesoridazine: Difference between revisions
Dr CareBear (talk | contribs) m reworded to make it clear that the class of drugs is called Phenothiazine |
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| routes_of_administration = oral, intravenous |
| routes_of_administration = oral, intravenous |
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| excretion = Biliary/Renal }} |
| excretion = Biliary/Renal }} |
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'''Mesoridazine besylate''' (trade name '''Serentil''') is a [[piperidine]] [[antipsychotic]] [[neuroleptic]] drug belonging to the class of drugs called [[phenothiazine]] that is used in the treatment of [[schizophrenia]], organic brain disorders, psychoneuroses, and [[alcoholism]]. It is the besylate salt of a metabolite of [[thioridazine]]. It exerts its actions through a central adrenergic-blocking, a [[dopamine]]-blocking, a [[serotonin]]-blocking, and a |
'''Mesoridazine besylate''' (trade name '''Serentil''') is a [[piperidine]] [[antipsychotic]] [[neuroleptic]] drug belonging to the class of drugs called [[phenothiazine]] that is used in the treatment of [[schizophrenia]], organic brain disorders, psychoneuroses, and [[alcoholism]]. It is the besylate salt of a metabolite of [[thioridazine]]. It exerts its actions through a central adrenergic-blocking, a [[dopamine]]-blocking, a [[serotonin]]-blocking, and a [[anticholinergic]] action. It also exerts part of its actions through depression of [[hypothalamus|hypothalamic]] centers, like other [[phenothiazine]]s. Serious side effects include [[tardive dyskinesia]] and the potentially fatal [[neuroleptic malignant syndrome]]. Patient compliance is low because of the agonizing side effect of [[akathisia]]. |
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Mesoridazine partially derives its name from the prefix "Meso" which means "middle" which is the center of the [[brain]] called the [[limbic system]] where most dopaminergic activity takes place. The middle of the brain also contains the [[pineal gland]] and [[hypothalamus]]. |
Mesoridazine partially derives its name from the prefix "Meso" which means "middle" which is the center of the [[brain]] called the [[limbic system]] where most dopaminergic activity takes place. The middle of the brain also contains the [[pineal gland]] and [[hypothalamus]]. |
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Revision as of 04:10, 6 June 2007
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| Clinical data | |
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| Pregnancy category |
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| Routes of administration | oral, intravenous |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Protein binding | 4% |
| Metabolism | Hepatic/Renal |
| Elimination half-life | 24 to 48 hours |
| Excretion | Biliary/Renal |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C21H26N2OS2 |
| Molar mass | 386.576 g/mol g·mol−1 |
Mesoridazine besylate (trade name Serentil) is a piperidine antipsychotic neuroleptic drug belonging to the class of drugs called phenothiazine that is used in the treatment of schizophrenia, organic brain disorders, psychoneuroses, and alcoholism. It is the besylate salt of a metabolite of thioridazine. It exerts its actions through a central adrenergic-blocking, a dopamine-blocking, a serotonin-blocking, and a anticholinergic action. It also exerts part of its actions through depression of hypothalamic centers, like other phenothiazines. Serious side effects include tardive dyskinesia and the potentially fatal neuroleptic malignant syndrome. Patient compliance is low because of the agonizing side effect of akathisia.
Mesoridazine partially derives its name from the prefix "Meso" which means "middle" which is the center of the brain called the limbic system where most dopaminergic activity takes place. The middle of the brain also contains the pineal gland and hypothalamus.
It was withdrawn from the United States market in 2004.