Neuroscience
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Neuroscience is the scientific study of the nervous system. Such studies span the structure, function, evolutionary history, development, genetics, biochemistry, physiology, pharmacology, informatics, computational neuroscience and pathology of the nervous system.
The International Brain Research Organization was founded in 1960,[1] the European Brain and Behaviour Society in 1968,[2] and the Society for Neuroscience in 1969,[3] but the study of the brain dates at least to ancient Egypt. Traditionally, neuroscience has been seen as a branch of the biological sciences. Recently, however, there has been a surge of interest from many allied disciplines, including cognitive and neuro-psychology, computer science, statistics, physics, philosophy, and medicine. The scope of neuroscience has now broadened to include any systematic, scientific, experimental or theoretical investigation of the central and peripheral nervous system of biological organisms. The empirical methodologies employed by neuroscientists have been enormously expanded, from biochemical and genetic analyses of the dynamics of individual nerve cells and their molecular constituents to imaging of perceptual and motor tasks in the brain. Recent theoretical advances in neuroscience have been aided by the use of computational modeling.
Overview
The scientific study of the nervous systems underwent a significant increase in the second half of the twentieth century, principally due to revolutions in molecular biology, electrophysiology, and computational neuroscience. It has become possible to understand, in much detail, the complex processes occurring within a single neuron. However, how networks of neurons produce intellectual behavior, cognition, emotion, and physiological responses is still poorly understood.
The task of neural science is to explain behavior in terms of the activities of the brain. How does the brain marshal its millions of individual nerve cells to produce behavior, and how are these cells influenced by the environment...? The last frontier of the biological sciences – their ultimate challenge – is to understand the biological basis of consciousness and the mental processes by which we perceive, act, learn, and remember. — Eric Kandel, Principles of Neural Science, fourth edition
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The nervous system is composed of a network of neurons and other supportive cells (such as glial cells). Neurons form functional circuits, each responsible for specific tasks to the behaviors at the organism level. Thus, neuroscience can be studied at many different levels, ranging from molecular level to cellular level to systems level to cognitive level.
At the molecular level, the basic questions addressed in molecular neuroscience include the mechanisms by which neurons express and respond to molecular signals and how axons form complex connectivity patterns. At this level, tools from molecular biology and genetics are used to understand how neurons develop and die, and how genetic changes affect biological functions. The morphology, molecular identity and physiological characteristics of neurons and how they relate to different types of behavior are also of considerable interest. (The ways in which neurons and their connections are modified by experience are addressed at the physiological and cognitive levels.)
At the cellular level, the fundamental questions addressed in cellular neuroscience are the mechanisms of how neurons process signals physiologically and electrochemically. They address how signals are processed by the dendrites, somas and axons, and how neurotransmitters and electrical signals are used to process signals in a neuron. Another major area of neuroscience is directed at investigations of the development of the nervous system. These questions of neural development include the patterning and regionalization of the nervous system, neural stem cells, differentiation of neurons and glia, neuronal migration, axonal and dendritic development, trophic interactions, and synapse formation.
At the systems level, the questions addressed in systems neuroscience include how the circuits are formed and used anatomically and physiologically to produce the physiological functions, such as reflexes, sensory integration, motor coordination, circadian rhythms, emotional responses, learning and memory. In other words, they address how these neural circuits function and the mechanisms through which behaviors are generated. For example, systems level analysis addresses questions concerning specific sensory and motor modalities: how does vision work? How do songbirds learn new songs and bats localize with ultrasound? How does the somatosensory system process tactile information? The related field of neuroethology, in particular, addresses the complex question of how neural substrates underlies specific animal behavior.
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At the cognitive level, cognitive neuroscience addresses the questions of how psychological/cognitive functions are produced by the neural circuitry. The emergence of powerful new measurement techniques such as neuroimaging (e. g.,fMRI, PET, SPECT), electrophysiology and human genetic analysis combined with sophisticated experimental techniques from cognitive psychology allows neuroscientists and psychologists to address abstract questions such as how human cognition and emotion are mapped to specific neural circuitries.
Neuroscience Education engages students from pre-Kindergarten through College in the study of neuroscience and provides training for Graduate students and Post-Doctoral fellows. Research in this area tests hypotheses pertaining to best practices in teaching and learning neuroscience concepts and can be funded through RO1 and R25 mechanism from NIH, major grants from NSF, and other federal and private granting mechanisms. Neuroscience Literacy includes efforts to raise knowledge and awareness about the nervous system and behavior among the general public, as well as public officials, policy makers, and legislators. Major world wide efforts in both Neuroscience Education and Neuroscience Literacy include Brain Awareness Week cosponsored by the Society for Neuroscience and Dana Alliance for Brain Initiatives, as well as the International Brain Bee which is an academic competition. Neuroscience Core Concepts for K-12 teachers and students have been developed by members of the public education and communications committee of the Society for Neuroscience. Brain Facts, a downloadable primer on human brain anatomy and function is currently being translated into Spanish and other world languages.
Neuroscience is also beginning to become allied with social sciences, and burgeoning interdisciplinary fields of neuroeconomics, decision theory, social neuroscience are starting to address some of the most complex questions involving interactions of brain with environment.
Neuroscience generally includes all scientific studies involving the nervous system. Psychology, as the scientific study of mental processes, is closely related to neuroscience, although the two disciplines are distinct, with such subjects as behaviorism and traditional cognitive psychology studied independently of the underlying neural processes. In Principles of Neural Science, Nobel laureate Eric Kandel contends that cognitive psychology is one of the pillar disciplines for understanding the brain in neuroscience. The term neurobiology is usually used interchangeably with neuroscience, although the former refers specifically to the biology of the nervous system, whereas the latter refers to the entire science of the nervous system.
Neurology, psychiatry, and neuropathology are medical specialties that specifically address the diseases of the nervous system. These terms also refer to clinical disciplines involving diagnosis and treatment of these diseases. Neurology deals with diseases of the central and peripheral nervous systems such as amyotrophic lateral sclerosis (ALS) and stroke, while psychiatry focuses on behavioural, cognitive, and emotional disorders. Neuropathology focuses upon the classification and underlying pathogenic mechanisms of central and peripheral nervous system and muscle diseases, with an emphasis on morphologic, microscopic and chemically observable alterations. The boundaries between these specialties have been blurring recently, and they are all influenced by basic research in neuroscience.
Integrative neuroscience makes connections across these specialized areas of focus.
History
Evidence of trepanation, the surgical practice of either drilling or scraping a hole into the skull with the aim of curing headaches or mental disorders or relieving cranial pressure, being performed on patients dates back to Neolithic times and has been found in various cultures throughout the world. Manuscripts dating back to 5000BC[citation needed] indicated that the Egyptians had some knowledge about symptoms of brain damage.
Early views on the function of the brain regarded it to be a "cranial stuffing" of sorts. In Egypt, from the late Middle Kingdom onwards, the brain was regularly removed in preparation for mummification. It was believed at the time that the heart was the seat of intelligence. According to Herodotus, during the first step of mummification: "The most perfect practice is to extract as much of the brain as possible with an iron hook, and what the hook cannot reach is mixed with drugs".[citation needed]
The view that the heart was the source of consciousness was not challenged until the time of Hippocrates. He believed that the brain was not only involved with sensation, since most specialized organs (e.g., eyes, ears, tongue) are located in the head near the brain, but was also the seat of intelligence. Aristotle, however, believed that the heart was the center of intelligence and that the brain served to cool the blood. This view was generally accepted until the Roman physician Galen, a follower of Hippocrates and physician to Roman gladiators, observed that his patients lost their mental faculties when they had sustained damage to their brains.
In al-Andalus, Abulcasis, the father of modern surgery, developed material and technical designs which are still used in neurosurgery. Averroes suggested the existence of Parkinson's disease and attributed photoreceptor properties to the retina. Avenzoar described meningitis, intracranial thrombophlebitis, mediastinal tumours and made contributions to modern neuropharmacology. Maimonides wrote about neuropsychiatric disorders and described rabies and belladonna intoxication.[4] Elsewhere in medieval Europe, Vesalius (1514-1564) and René Descartes (1596-1650) also made several contributions to neuroscience.
Studies of the brain became more sophisticated after the invention of the microscope and the development of a staining procedure by Camillo Golgi during the late 1890s that used a silver chromate salt to reveal the intricate structures of single neurons. His technique was used by Santiago Ramón y Cajal and led to the formation of the neuron doctrine, the hypothesis that the functional unit of the brain is the neuron. Golgi and Ramón y Cajal shared the Nobel Prize in Physiology or Medicine in 1906 for their extensive observations, descriptions and categorizations of neurons throughout the brain. The hypotheses of the neuron doctrine were supported by experiments following Galvani's pioneering work in the electrical excitability of muscles and neurons. In the late 19th century, DuBois-Reymond, Müller, and von Helmholtz showed neurons were electrically excitable and that their activity predictably affected the electrical state of adjacent neurons.
In parallel with this research, work with brain-damaged patients by Paul Broca suggested that certain regions of the brain were responsible for certain functions. At the time Broca's findings were seen as a confirmation of Franz Joseph Gall's theory that language was localized and certain psychological functions were localized in the cerebral cortex.[5][6] The localization of function hypothesis was supported by observations of epileptic patients conducted by John Hughlings Jackson, who correctly deduced the organization of motor cortex by watching the progression of seizures through the body. Wernicke further developed the theory of the specialization of specific brain structures in language comprehension and production. Modern research still uses the Brodmann cytoarchitectonic (referring to study of cell structure) anatomical definitions from this era in continuing to show that distinct areas of the cortex are activated in the execution of specific tasks.[7]
Major branches
![]() | It has been suggested that Neuroscience studies be merged into this article. (Discuss) Proposed since July 2009. |
Current neuroscience education and research activities can be very roughly categorized into the following major branches, based on the subject and scale of the system in examination as well as distinct experimental or curricular approaches. Individual neuroscientists, however, often work on questions that span several distinct subfields.
Note: In 1990s, neuroscientist Jaak Panksepp coined the term "affective neuroscience"[8] to emphasize that emotion research should be a branch of neurosciences, distinguishable from the nearby fields like cognitive neuroscience or behavioral neuroscience. More recently, the social aspect of the emotional brain has been integrated in what is called "social-affective neuroscience" or simply social neuroscience.
There has also been some research published arguing that some of fair play and the Golden Rule may be stated and rooted in terms of neuroscientific and neuroethical principles.[9]
Major themes of research
Neuroscience research from different areas can also be seen as focusing on a set of specific themes and questions. (Some of these are taken from http://www.northwestern.edu/nuin/fac/index.htm)
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Allied and overlapping fields
Neuroscience, by its very interdisciplinary nature, overlaps with and encompasses many different subjects. Below is a list of related subjects and fields.
Future directions
See also
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- List of neuroscience topics
- List of neuroscientists
- Important publications in neuroscience
- Neuroscience journals
- Neuroscience research institutes, such as Monell Chemical Senses Center
References
- ^ "International Brain Research Organization (IBRO)".
- ^ "ABOUT EBBS". Retrieved 2009-05-03.
- ^ "Society for Neuroscience: Presidents".
- ^ Martin-Araguz, A.; Bustamante-Martinez, C.; Fernandez-Armayor, Ajo V.; Moreno-Martinez, J. M. (2002). "Neuroscience in al-Andalus and its influence on medieval scholastic medicine", Revista de neurología 34 (9), p. 877-892.
- ^ Greenblatt, SH., (1995) "Phrenology in the science and culture of the 19th century, " Neurosurgery 37 790-805.
- ^ Bear, M. F.; B. W. Connors, and M. A. Paradiso (2001). Neuroscience: Exploring the Brain. Baltimore: Lippincott. ISBN 0-7817-3944-6.
- ^ Principles of Neural Science, 4th ed. Eric R. Kandel, James H. Schwartz, Thomas M. Jessel, eds. McGraw-Hill:New York, NY. 2000.
- ^ Panksepp, J., 1990 - A role for “affective neuroscience” in understanding stress: The case of separation distress circuitry. In: Puglisi-Allegra, S. and Oliverio, A., Editors, 1990, Psychobiology of stress, Kluwer, Dordrecht, pp. 41–58.
- ^ Pfaff, Donald W., "The Neuroscience of Fair Play: Why We (Usually) Follow the Golden Rule", Dana Press, The Dana Foundation, New York, 2007. ISBN 9781932594270
Further reading
- Bear, M. F. (2006). Neuroscience: Exploring the Brain (3rd ed.). Philadelphia: Lippincott. ISBN 0781760038.
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- Binder/Hirokawa/Windhorst (2009, 4399pp, 5 vols). Encyclopedia of Neuroscience. Springer. ISBN 978-3-540-23735-8.
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- Kandel, ER (2000). Principles of Neural Science (4th ed.). New York: McGraw-Hill. ISBN 0-8385-7701-6.
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- Squire, L. et al. (2003). Fundamental Neuroscience, 2nd edition. Academic Press; ISBN 0-12-660303-0
- Byrne and Roberts (2004). From Molecules to Networks. Academic Press; ISBN 0-12-148660-5
- Sanes, Reh, Harris (2005). Development of the Nervous System, 2nd edition. Academic Press; ISBN 0-12-618621-9
- Siegel et al. (2005). Basic Neurochemistry, 7th edition. Academic Press; ISBN 0-12-088397-X
- Rieke, F. et al. (1999). Spikes: Exploring the Neural Code. The MIT Press; Reprint edition ISBN 0-262-68108-0
- section.47 Neuroscience 2nd ed. Dale Purves, George J. Augustine, David Fitzpatrick, Lawrence C. Katz, Anthony-Samuel LaMantia, James O. McNamara, S. Mark Williams. Published by Sinauer Associates, Inc., 2001.
- section.18 Basic Neurochemistry: Molecular, Cellular, and Medical Aspects 6th ed. by George J. Siegel, Bernard W. Agranoff, R. Wayne Albers, Stephen K. Fisher, Michael D. Uhler, editors. Published by Lippincott, Williams & Wilkins, 1999.
- Andreasen, Nancy C. (2004). Brave New Brain: Conquering Mental Illness in the Era of the Genome. Oxford University Press. ISBN 9780195145090.
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- Damasio, A. R. (1994). Descartes' Error: Emotion, Reason, and the Human Brain. New York, Avon Books. ISBN 0-399-13894-3 (Hardcover) ISBN 0-380-72647-5 (Paperback)
- Gardner, H. (1976). The Shattered Mind: The Person After Brain Damage. New York, Vintage Books, 1976 ISBN 0-394-71946-8
- Goldstein, K. (2000). The Organism. New York, Zone Books. ISBN 0-942299-96-5 (Hardcover) ISBN 0-942299-97-3 (Paperback)
- Llinas R. (2001). I of the Vortex: From Neurons to Self MIT Press. ISBN 0-262-12233-2 (Hardcover) ISBN 0-262-62163-0 (Paperback)
- Luria, A. R. (1997). The Man with a Shattered World: The History of a Brain Wound. Cambridge, Massachusetts, Harvard University Press. ISBN 0-224-00792-0 (Hardcover) ISBN 0-674-54625-3 (Paperback)
- Luria, A. R. (1998). The Mind of a Mnemonist: A Little Book About A Vast Memory. New York, Basic Books, Inc. ISBN 0-674-57622-5
- Medina, J. (2008). Brain Rules: 12 Principles for Surviving and Thriving at Work, Home, and School. Seattle, Pear Press. ISBN 0-979-777704 (Hardcover with DVD)
- Pinker, S. (1999). How the Mind Works. W. W. Norton & Company. ISBN 0-393-31848-6
- Pinker, S. (2002). The Blank Slate: The Modern Denial of Human Nature. Viking Adult. ISBN 0-670-03151-8
- Ramachandran, V. S. (1998). Phantoms in the Brain. New York, New York Harper Collins. ISBN 0-688-15247-3 (Paperback)
- Rose, S. (2006). 21st Century Brain: Explaining, Mending & Manipulating the Mind ISBN 0099429772 (Paperback)
- Sacks, O. The Man Who Mistook His Wife for a Hat. Summit Books ISBN 0-671-55471-9 (Hardcover) ISBN 0-06-097079-0 (Paperback)
- Sacks, O. (1990). Awakenings. New York, Vintage Books. (See also Oliver Sacks) ISBN 0-671-64834-9 (Hardcover) ISBN 0-06-097368-4 (Paperback)
- Sternberg, E. (2007) Are You a Machine? The Brain, the Mind and What it Means to be Human. Amherst, NY: Prometheus Books.
External links
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