Goitrogen
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Goitrogens are substances that suppress the function of the thyroid gland by interfering with iodine uptake, which can, as a result, cause an enlargement of the thyroid, i.e., a goiter.
Goitrogenic drugs and chemicals
Chemicals that have been shown to have goitrogenic effects include:
- Sulfadimethoxine, propylthiouracil, potassium perchlorate, and iopanoic acid.[1]
- Some oxazolidines such as goitrin.[2]
- Thiocyanate overload in Central Africa, especially if also in conjunction with selenium deficiency.[3] Reliance on cassava as a carbohydrate provides a source of thiocyanate in some areas.[4]
- Ions such as thiocyanate and perchlorate decrease iodide uptake by competitive inhibition and, as a consequence of reduced thyroxine and triiodothyronine secretion by the gland, cause, at low doses, an increased release of thyrotropin (by reduced negative feedback), which then stimulates the gland.[5]
- Amiodarone inhibits peripheral conversion of thyroxine to triiodothyronine; also interferes with thyroid hormone action.
- Lithium inhibits thyroid hormone release.
- Phenobarbitone, phenytoin, carbamazepine, rifampin induce metabolic degradation of triiodothyronine (T3) and thyroxine (T4).
Goitrogenic foods
Certain raw foods (cooking partially inactivates the goitrogens, except in the cases of soy and millet[citation needed]) have been identified as lightly goitrogenic. These foods include:
- Cassava and Cabbage both due to the foods containing thiocyanate[6]
- Soybeans (and soybean products such as tofu, soybean oil, soy flour, soy lecithin)
- Other foods containing genistein have been implicated as interfering with thyroid peroxidase in laboratory rats.[7]
- Pine nuts
- Peanuts
- Millet
- Strawberries
- Pears
- Peaches
- Spinach
- Bamboo shoots
- Sweet Potatoes
- Vegetables in the genus Brassica [8]
- Bok choy
- Broccoli
- Broccolini (Asparations)
- Brussels sprouts
- Cabbage
- Canola
- Cauliflower
- Chinese cabbage
- Choy sum
- Collard greens
- Horseradish
- Kai-lan (Chinese broccoli)
- Kale
- Kohlrabi
- Mizuna
- Mustard greens
- Radishes
- Rapeseed (yu choy)
- Rapini
- Rutabagas (swedes)
- Tatsoi
- Turnips
Thyroid hyperplasia has been demonstrated in mice:[9]
Despite being generally a stimulant, caffeine acts on thyroid function as a suppressant.[citation needed] Indeed some studies on rats suggest that excess caffeine in conjunction with a lack of iodine may promote the formation of thyroid cancers.[10]
Foods stimulating thyroid tissue
Some foods and drinks have an opposite effect on the thyroid gland; that is, they stimulate thyroid function rather than suppressing it, examples being avocado and saturated fat. [citation needed]
See also
References
- ^ Takizawa T, Imai T, Ueda M, Onodera H, Hirose M (2006). "Comparison of enhancing effects of different goitrogen treatments in combination with beta-estradiol-3-benzoate for establishing a rat two-stage thyroid carcinogenesis model to detect modifying effects of estrogenic compounds". Cancer Sci. 97 (1): 25–31. doi:10.1111/j.1349-7006.2005.00132.x. PMID 16367917.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Verhoeven DT, Verhagen H, Goldbohm RA, van den Brandt PA, van Poppel G (1997). "A review of mechanisms underlying anticarcinogenicity by brassica vegetables". Chem. Biol. Interact. 103 (2): 79–129. doi:10.1016/S0009-2797(96)03745-3. PMID 9055870.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Vanderpas J (2006). "Nutritional epidemiology and thyroid hormone metabolism". Annu. Rev. Nutr. 26: 293–322. doi:10.1146/annurev.nutr.26.010506.103810. PMID 16704348.
- ^ Akindahunsi AA, Grissom FE, Adewusi SR, Afolabi OA, Torimiro SE, Oke OL (1998). "Parameters of thyroid function in the endemic goitre of Akungba and Oke-Agbe villages of Akoko area of southwestern Nigeria". African journal of medicine and medical sciences. 27 (3–4): 239–42. PMID 10497657.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info:doi/10.1289/ehp.02110927
- ^ http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info:doi/10.1289/ehp.02110927
- ^ Doerge DR, Sheehan DM (2002). "Goitrogenic and estrogenic activity of soy isoflavones". Environ. Health Perspect. 110 Suppl 3: 349–53. PMC 1241182. PMID 12060828.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7.
{{cite book}}: CS1 maint: multiple names: authors list (link) 8th edition. - ^ National Toxicology, Program (2001). "Toxicology and carcinogenesis studies of coconut oil acid diethanolamine condensate (CAS No. 68603-42-9) in F344/N rats and B6C3F1 mice (dermal studies)". National Toxicology Program technical report series. 479: 5–226. PMID 12571684.
- ^ Son HY, Nishikawa A, Kanki K; et al. (2003). "Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine". Cancer Sci. 94 (4): 334–7. doi:10.1111/j.1349-7006.2003.tb01442.x. PMID 12824900.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
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