Talk:Ketamine

Cleanup

This article is a little messy and could do with some rearranging. The medicinal uses part needs some subsections, and some thought might be given to partial merge with the medical research section. — Preceding unsigned comment added by Testem (talk • contribs) 10:28, 15 January 2014

Intro Paragraph

Common side effects include psychological reactions as the medication wears off.[4] These reactions may include agitation, confusion, or psychosis.[4][8] Elevated blood pressure and muscle tremors are relatively common, while low blood pressure and a decrease in breathing is less so.[4][8] Spasms of the larynx may rarely occur.

The claim that side effects occur "as the medication wears off" doesn't seem to have any basis. There's no indication in either source (both drugs.com pages) when the side effects occur. This is problematic since it implies lingering effects that may not exist and are not indicated in the references. (Though the special note in ref [4] specifically indicates that while some side effects may recur over a 24h period, no residual psych. effects are known.) Unless anyone has any further info on the side effects, I'd say remove the "as the medication wears off" portion. ParoXoN (talk) 23:11, 16 February 2016 (UTC)

it is best to read the body if something seems wrong in the lead. the lead just summarizes the body. there was more content there for it, and a ref Jytdog (talk) 00:51, 17 February 2016 (UTC)

reactions and supplication

supposedly alternatively, ketamin, inhibits psychosis within the hippocampus, as a prospective psi medication. next, the secret of ancient ketae, est min, elemental "antimony" ketamin could mix with selenium, also seemingly entails combination with benz-thio cyclyenol analogue. lasty, wild keta minerals exist next to the andes such as local of argenina and pacific side of continent southern, — Preceding unsigned comment added by Wezenlucif (talk • contribs) 02:33, 24 February 2016 (UTC)

Expand Depression Section

Numerous studies have emerged stating Ketamine's benefit for treatment-resistant depression, and this is perhaps the most consequential development pertaining to this drug in recent memory. However, the depression section of this article is terse with descriptions of efficacy relying on outdated studies. The article does not describe how the drug acts on depression (hypothesized MOA), the emergence of ketamine clinics delivering infusions to treatment resistant patients, or Ketamine's relationship to the development of glutamatergic antidepressants. The articles on ketamine's enantiomers are even more fully fleshed-out in this respect. 68.185.202.126 (talk) 04:38, 26 April 2016 (UTC)ddiamondds

Ketamine's antidepressant action possibly caused by AMPAR inhibition rather than NMDAR inhibition.

Hi! After seeing it on the NIH Director's blog, I added some information about indications that ketamine's fast-acting antidepressant effects may be caused by one of its metabolites, which doesn't have the same potential for abuse. (Study published in Nature.) It's been integrated into the article for hydroxynorketamine, the metabolite in question. The revert message says to look at WP:MEDRS; this is recently published, so it doesn't appear in any reviews yet, but it seems important enough to include at least some note of it. ("If conclusions are worth mentioning [...] they should be described appropriately as from a single study".) Am I missing something here? Thanks! grendel|khan 00:59, 15 May 2016 (UTC)

Thanks for opening this, I was about to. User:Doc James and User:Seppi333, are you good with the current version here? I am somewhat surprised at myself for arguing to keep this content based on a primary source, but seeing how we do use primaries for purely PK stuff (seppi's objection here was dead on) I don't see a reason to exclude this now. And it is a major upheaval in the understanding of how this drug works, i think.... If you all say yes wait for a review I can only bow to that, of course. Jytdog (talk) 01:23, 15 May 2016 (UTC)

The current version seems fine; the sources for the current statement should only need to satisfy WP:SCIRS, which they do. Seppi333 (Insert 2¢) 01:30, 15 May 2016 (UTC)

Maybe I'm missing the point here, but the whole reason this is an interesting finding is that HNK doesn't have the same side effects and abuse potential, right? Even if the main question here--HNK has ketamine's antidepressant effects--is still under investigation, that's valuable context, right? grendel|khan 00:33, 22 May 2016 (UTC)

It is interesting for a lot of reasons. But we are limited by what we can say based on a given source by the sourcing guideline. To make claims in content about health we need a review in the biomedical literature. I have no doubt one will be forthcoming soon that talks about this. It just a matter of waiting a bit. Jytdog (talk) 01:13, 22 May 2016 (UTC)

Hi

Is Scotland's drug classification different from rest of UK's?--Armanikoka (talk) 00:03, 21 July 2016 (UTC)

Citations needed

In the Anaesthesia section the statement "It is sometimes possible to perform ketamine anesthesia without protective measures to the airways." is not referenced. There does not appear to be a readily apparent source for this statement. This is often the case in animal anaesthesia where Ketamine or a combination with it and another anaesthetic is used without airway support. However in human anaesthesia, it does not appear to be used without airway support due to its pro-salivary properties: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25886322/

In the Vetinary Medicine section, the statement "Ketamine is used to manage pain among large animals, though it has less effect on bovines." is not referenced. There does not appear to be any scientific articles that make note of a lesser effect on bovines relative to other animals. Given the complexity of inter-species dose scaling, I wonder if this statement is useful.