^ abcdThe Bills traded their first-, fifth- and sixth-round selections and 2021 fourth-round selection to the Minnesota Vikings in exchange for Minnesota's seventh-round selection (CB Dane Jackson) and WR Stefon Diggs.[1]
^ abThe Bills traded a 2021 seventh-round selection and G Wyatt Teller to the Cleveland Browns in exchange for Cleveland's fifth- and sixth-round selections (155th and 188th overall).[2]
Networks and times for Sunday games from Weeks 5-17 are subject to change as a result of flexible scheduling.
As the result of Saturday flexible scheduling during Week 15, the date, time and network for that week's game at the Denver Broncos will be finalized at a later date-- by no later than four weeks prior to game day.[6]
Game summaries
Week 1: vs. New York Jets
Week One: New York Jets at Buffalo Bills – Game summary
Buffalo raced to a 28–3 lead in the middle of the third quarter, but after a pass from QB Josh Allen to TE Tyler Kroft was controversially ruled an interception for Los Angeles as Rams DB John Johnson III grabbed the ball moments after Kroft caught it, the Rams erased the deficit and took over the lead in the fourth quarter.[7] Allen would nonetheless lead a game-winning drive in the final four minutes of the game, including three crucial passes to WR Cole Beasley, capping it off with a touchdown pass to Kroft following a defensive pass interference call on Darious Williams on 4th and 9.[8] With the win, Buffalo earned a 3–0 start for the second year in a row.
Week 4: at Las Vegas Raiders
Week Four: Buffalo Bills at Las Vegas Raiders – Game summary
Buffalo scored first on the opening drive of the game when Josh Allen found a wide open Gabriel Davis for a 26-yard TD. The Bills would not lose the lead for the remainder of the game, with Allen continuing his hot start to the season. Late in the second quarter, Allen scrambled and found Stefon Diggs for a 9-yard gain, taking a big hit from Raiders DE Arden Key, resulting in an injury to the left shoulder. He would return later in the game and score a 1-yard QB sneak, along with 136 yards passing in the second half, with his longest being a 49-yard throw to Diggs. Buffalo would win and go to 4-0 for the first time since 2008.
Week 5: at Tennessee Titans
Week Five: Buffalo Bills at Tennessee Titans – Game summary
^ abTennessee finished ahead of Indianapolis based on division record.
^ abBaltimore finished ahead of Indianapolis based on head-to-head victory. Division tiebreaker used to eliminate Cleveland (see below).
^ abBaltimore finished ahead of Cleveland based on head-to-head sweep.
^ abCleveland finished ahead of Indianapolis based on head-to-head victory.
^ abNew England finished ahead of the LA Chargers based on head-to-head victory.
^When breaking ties for three or more teams under the NFL's rules, they are first broken within divisions, then comparing only the highest ranked remaining team from each division.