3-(3-hydroxyphenyl)propanoate hydroxylase
| 3-(3-hydroxyphenyl)propanoate hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.127 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3-(3-hydroxyphenyl)propanoate hydroxylase (EC 1.14.13.127, mhpA (gene)) is an enzyme with systematic name 3-(3-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (2-hydroxylating).[1][2][3][4] This enzyme catalyses the following chemical reaction
- (1) 3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+
- (2) (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + H+ + O2 (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+
3-(3-hydroxyphenyl)propanoate hydroxylase is a flavoprotein (FAD).
References
- ^ Burlingame, R.; Chapman, P.J. (1983). "Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli". J. Bacteriol. 155 (1): 113–121. PMC 217659. PMID 6345502.
- ^ Burlingame, R.P.; Wyman, L.; Chapman, P.J. (1986). "Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation". J. Bacteriol. 168 (1): 55–64. PMC 213419. PMID 3531186.
- ^ Ferrández, A.; Garciá, J.L.; Díaz, E. (1997). "Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12". J. Bacteriol. 179 (8): 2573–2581. PMC 179006. PMID 9098055.
- ^ Díaz, E.; Ferrández, A.; García, J.L. (1998). "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". J. Bacteriol. 180 (11): 2915–2923. PMC 107259. PMID 9603882.
External links
- 3-(3-hydroxyphenyl)propanoate+hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)