Respiratory syncytial virus vaccine
A respiratory syncytial virus vaccine (RSV vaccine) is a vaccine which prevents infection by respiratory syncytial virus. No such vaccine exists at this time.
Attempts to develop an RSV vaccine began in the 1960s with an unsuccessful inactivated vaccine developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)).[1] Unfortunately, this vaccine induced a phenomenon that came to be known as "vaccine-associated enhanced respiratory disease" (VAERD), in which children who had not previously been exposed to RSV and were subsequently vaccinated would develop a severe form of RSV disease if exposed to the virus itself, including fever, wheezing, and bronchopneumonia.[1] Some eighty percent of such children (vs. 5% of virus-exposed controls) were hospitalized, and two children died lethal – lung inflammatory response during the first natural RSV infection after vaccination of RSV-naive infants.[1] This disaster hindered vaccine development for many years to come.[1]
A 1998 paper reported that research toward developing a vaccine had advanced greatly over the previous 10 years.[2] The desired vaccine would prevent lower respiratory infection from RSV in at-risk populations and if possible be useful in other populations with less risk.[2] Twenty years later, a 2019 paper similarly claimed that research toward developing a vaccine had advanced greatly over the prior 10 years.[3] The same study predicted that a vaccine would be available within 10 years.[3]
The current types of vaccines which are in research are particle-based vaccines, attenuated vaccines, protein subunit vaccines, or vector-based vaccines.[4]
References
- ^ a b c d Acosta PL, Caballero MT, Polack FP (December 16, 2015). "Brief History and Characterization of Enhanced Respiratory Syncytial Virus Disease". Clin Vaccine Immunol. 23 (3): 189–95. doi:10.1128/CVI.00609-15. PMC 4783420. PMID 26677198. Retrieved 24 September 2020.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b Dudas, RA; Karron, RA (July 1998). "Respiratory syncytial virus vaccines". Clinical Microbiology Reviews. 11 (3): 430–9. doi:10.1128/CMR.11.3.430. PMC 88889. PMID 9665976.
- ^ a b Mejias, Asuncion; Rodriguez-Fernandez, Rosa; Peeples, Mark E.; Ramilo, Octavio (October 2019). "Respiratory Syncytial Virus Vaccines". The Pediatric Infectious Disease Journal. 38 (10): e266–e269. doi:10.1097/INF.0000000000002404. PMID 31335571.
- ^ Mazur, Natalie I; Higgins, Deborah; Nunes, Marta C; Melero, José A; Langedijk, Annefleur C; Horsley, Nicole; Buchholz, Ursula J; Openshaw, Peter J; McLellan, Jason S; Englund, Janet A; Mejias, Asuncion; Karron, Ruth A; Simões, Eric AF; Knezevic, Ivana; Ramilo, Octavio; Piedra, Pedro A; Chu, Helen Y; Falsey, Ann R; Nair, Harish; Kragten-Tabatabaie, Leyla; Greenough, Anne; Baraldi, Eugenio; Papadopoulos, Nikolaos G; Vekemans, Johan; Polack, Fernando P; Powell, Mair; Satav, Ashish; Walsh, Edward E; Stein, Renato T; Graham, Barney S; Bont, Louis J (October 2018). "The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates" (PDF). The Lancet Infectious Diseases. 18 (10): e295–e311. doi:10.1016/S1473-3099(18)30292-5. PMID 29914800.