Tripeptidyl-peptidase 2 is an enzyme that in humans is encoded by the TPP2gene.[5][6] Among other things it is heavily implicated in MHC (HLA) class-I processing, as it has both endopeptidase and exopeptidase activity.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tomkinson B, Jonsson AK (Feb 1991). "Characterization of cDNA for human tripeptidyl peptidase II: the N-terminal part of the enzyme is similar to subtilisin". Biochemistry. 30 (1): 168–74. doi:10.1021/bi00215a025. PMID1670990.
^Reits E; Neijssen J; Herberts C; et al. (April 2004). "A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation". Immunity. 20 (4): 495–506. doi:10.1016/S1074-7613(04)00074-3. PMID15084277. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
External links
The MEROPS online database for peptidases and their inhibitors: S08.090
Tomkinson B (1992). "Nucleotide sequence of cDNA covering the N-terminus of human tripeptidyl peptidase II". Biomed. Biochim. Acta. 50 (4–6): 727–9. PMID1840501.
Wilson C, Gibson AM, McDermott JR (1993). "Purification and characterization of tripeptidylpeptidase-II from post-mortem human brain". Neurochem. Res. 18 (7): 743–9. doi:10.1007/BF00966768. PMID8396212.
Martinsson T, Vujic M, Tomkinson B (1993). "Localization of the human tripeptidyl peptidase II gene (TPP2) to 13q32-q33 by nonradioactive in situ hybridization and somatic cell hybrids". Genomics. 17 (2): 493–495. doi:10.1006/geno.1993.1353. PMID8406500.
Rose C; Vargas F; Facchinetti P; et al. (1996). "Characterization and inhibition of a cholecystokinin-inactivating serine peptidase". Nature. 380 (6573): 403–9. doi:10.1038/380403a0. PMID8602240. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Geier E; Pfeifer G; Wilm M; et al. (1999). "A giant protease with potential to substitute for some functions of the proteasome". Science. 283 (5404): 978–81. doi:10.1126/science.283.5404.978. PMID9974389. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ganellin CR; Bishop PB; Bambal RB; et al. (2000). "Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors". J. Med. Chem. 43 (4): 664–74. doi:10.1021/jm990226g. PMID10691692. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Lindås AC, Tomkinson B (2005). "Identification and characterization of the promoter for the gene encoding human tripeptidyl-peptidase II". Gene. 345 (2): 249–257. doi:10.1016/j.gene.2004.11.042. PMID15716107.
Stavropoulou V; Vasquez V; Cereser B; et al. (2006). "TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints". Biochem. Biophys. Res. Commun. 346 (2): 415–25. doi:10.1016/j.bbrc.2006.05.141. PMID16762321. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Lindås AC, Tomkinson B (2007). "Characterization of the promoter of the gene encoding human tripeptidyl-peptidase II and identification of upstream silencer elements". Gene. 393 (1–2): 62–69. doi:10.1016/j.gene.2007.01.015. PMID17343995.