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Amanda Fisher

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For the fictional character, see Amanda Fisher (Ash vs Evil Dead).
Amanda Fisher
Amanda Fisher in 2014, portrait via the Royal Society
Born
Amanda Gay Fisher
Alma materUniversity of Birmingham[1]
Awards
Scientific career
InstitutionsImperial College London
ThesisSurface antigens expressed during myelopoiesis (1984)
Websitewww3.imperial.ac.uk/people/amanda.fisher

Amanda Gay Fisher FRS is a British cell biologist and professor at Imperial College London where she leads the Institute of Clinical Sciences.[2][3][4][5][6][7][8] She has made contributions to multiple areas of cell biology, including determining the function of several genes in HIV and describing the importance of a gene’s location within the nucleus of the cell.

As a postdoctoral scientist, she produced the first functional copies of HIV, providing researchers with access to enough biologically active material to study the function of the virus’s genes. She later became interested in epigenetics and nuclear reprogramming, particularly in white blood cells known as lymphocytes and embryonic stem cells. Her current research focuses on how gene expression patterns are inherited when cells divide, using lymphocytes as a model system.[9]

Education

Fisher was educated at the University of Birmingham where she was awarded a PhD in 1984 for research into Myelopoiesis.[10]

Awards and honours

She won the 2002 EMBO Gold Medal in recognition of her work on nuclear organization and gene expression, as well as for her research on the molecular characterisation of the AIDS virus (HIV).[11]

In 2014, she was elected to the Royal Society.[12] Her nomination reads:

Amanda Fisher is distinguished for her pioneering work on HIV pathogenesis, T lymphocyte development, embryonic stem cells and epigenetic gene regulation. She described the first active clones of HIV and discovered the functions of several HIV genes including tat, nef and vif. In T lymphocytes she showed that a gene's position within the nucleus is important for maintaining heritable gene silencing. In embryonic stem cells she showed that important developmental regulator genes can be "poised" for expression whilst being repressed by polycomb repressor complexes.[12]

References

  1. ^ Fisher, A. G.; Brown, G (1980). "A rapid method for determining whether monoclonal antibodies react with the same or different antigens on the cell surface". Journal of immunological methods. 39 (4): 377–85. doi:10.1016/0022-1759(80)90238-0. PMID 7007517.
  2. ^ "Professor Amanda Fisher". imperial.ac.uk. Retrieved 2014-05-25.
  3. ^ Amanda Fisher's publications indexed by the Scopus bibliographic database. (subscription required)
  4. ^ Azuara, V; Perry, P; Sauer, S; Spivakov, M; Jørgensen, H. F.; John, R. M.; Gouti, M; Casanova, M; Warnes, G; Merkenschlager, M; Fisher, A. G. (2006). "Chromatin signatures of pluripotent cell lines". Nature Cell Biology. 8 (5): 532–8. doi:10.1038/ncb1403. PMID 16570078.
  5. ^ Brown, K. E.; Guest, S. S.; Smale, S. T.; Hahm, K.; Merkenschlager, M.; Fisher, A. G. (1997). "Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin". Cell. 91 (6): 845–54. doi:10.1016/S0092-8674(00)80472-9. PMID 9413993.
  6. ^ Kosak, S. T.; Skok, J. A.; Medina, K. L.; Riblet, R; Le Beau, M. M.; Fisher, A. G.; Singh, H (2002). "Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development". Science. 296 (5565): 158–62. doi:10.1126/science.1068768. PMID 11935030.
  7. ^ "Amanda Fisher receives EMBO Gold Medal". www3.scienceblog.com. Retrieved 2014-05-25.
  8. ^ ""Epigenetic reprogramming" - lecture of Amanda Fisher | Science videos". epigenesys.eu. Retrieved 2014-05-25.
  9. ^ "Royal Society: Amanda Fisher Biography". The Royal Society. Retrieved 2015-10-13.
  10. ^ Fisher, Amanda Gay (1984). Surface antigens expressed during myelopoiesis (PhD thesis). University of Birmingham.
  11. ^ "Amanda Fisher receives EMBO ...( Amanda Fisher group head at the MRC Cl...)". news.bio-medicine.org. Retrieved 2014-05-25.
  12. ^ a b "Professor Amanda Fisher FMedSci FRS | Royal Society". royalsociety.org. Retrieved 2014-05-25.
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