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Amphenicols are a class of antibiotics with a phenylpropanoid structure. They function by blocking the enzyme peptidyl transferase on the 50S ribosome subunit of bacteria.[1]

Examples of amphenicols include chloramphenicol, thiamphenicol, azidamfenicol and florfenicol. The first-in-class compound was chloramphenicol, introduced in 1949. Chloramphenicol was initially discovered as a natural product, but all amphenicols are now made by chemical synthesis.


  1. ^ "APVMA: Florfenicol". Archived from the original on 2007-09-07. Retrieved 2007-07-22. Cite uses deprecated parameter |dead-url= (help)