Artemotil

Artemotil
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy; category	not available;
Routes of; administration	Intramuscular injection
ATC code	P01BE04 (WHO) ;
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	20 hours
Identifiers
	IUPAC name (5aS,6R,8aS,9R,10S,12R,12aR)-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene;
CAS Number	75887-54-6 ;
PubChem CID	3000469;
ChemSpider	2272064 ;
UNII	XGL7GFB9YI;
ChEMBL	ChEMBL301267 ;
Chemical and physical data
Formula	C17H28O5
Molar mass	312.401 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCO[C@@H]1[C@@H]([C@@H]2CC[C@H]([C@H]3[C@]24[C@H](O1)O[C@@](CC3)(OO4)C)C)C;
	InChI InChI=1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1 ; Key:NLYNIRQVMRLPIQ-XQLAAWPRSA-N ;
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Artemotil (INN; also known as β-arteether), is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua. It is currently only used as a second line drug in severe cases of malaria.

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