About the making of the album, Dee Dee wrote in his autobiography, Lobotomy: Surviving the Ramones:
It was tough recording the Brain Drain album because everyone took their shit out on me. I dreaded being around them. It drove me away — I didn't even end up playing on the album. Everybody in the band had problems; girlfriend problems, money problems, mental problems.
In the music videos for "Pet Sematary", Dee Dee Ramone played the bass but in "I Believe In Miracles" & "Merry Christmas (I Don't Wanna Fight Tonight)", C. J. Ramone replaced Dee Dee's position as a bassist. "Merry Christmas (I Don't Want To Fight Tonight)" was covered by Joey Ramone on his second posthumous album Ya Know?.
"Merry Christmas (I Don't Want To Fight Tonight)" was included in the movie soundtrack Christmas With The Kranks.