The new board of directors was officially formed under the presidency of Emilio Núñez Torrón on Wednesday, July 8, 1953. CD Lugo played its first official match against Pontevedra CF on Sunday, September 13, 1953. Lugo won it 3:1. With the new configuration of the Tercera División from the 1956-57 season Lugo permanently played there for many further years. In the 1961-62 Lugo led by the coach Luis Diestro won its first trophy, becoming Tercera División champion.
Lugo promoted for the first time to Segunda División in 1992, but could not remain more than one season in the league. The 1992-93 season was unsuccessful for the club, as it had only 25 points in 38 games and finished in the 18th position among 20 teams. Lugo became a representative of the middle class of the Segunda División B. Between 1994 and 2000 the club had no problems to remain its place in the league.
In 2013 the club started its second consecutive season in the Segunda. Lugo finished in 12th position with 54 points, just 4 points from being relegated to Segunda División B.
The 2014-15 season was the sixth and the last for the coach Quique Setién. With 49 points Lugo reached 15th position and achieved the goal to retain its place in Segunda División.Luis Milla was chosen as a new coach for the 2015-16 season. Unfortunately, he left the club in February 2016. He explained that it was due to personal reasons and the club accepted his resignation.
In October 2017, after twelve rounds of the 2017–18 season, Lugo for the first time in their history led the table of the Segunda División. However, the team finished that season in the 12th position.
During the 2018-19 season Lugo was fighting for remaining in the Segunda División, and finally ended up on the 18th position which helped to remain for the seventh consecutive season in the second Spanish division. The club didn't lose in the last 6 games of the season which helped to finish just 2 points above the relegation zone.