CGS-21680

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CGS-21680
CGS21680.png
Names
IUPAC name
3-[4-[2-[ [6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid
Other names
CGS 21680
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
Properties
C23H29N7O6
Molar mass 499.52
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

CGS-21680 is a specific adenosine A2A subtype receptor agonist. It is usually presented as an organic hydrochloride salt with a molecular weight of 536.0 g/M. It is soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin.

The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity, subtype specific analogue for adenosine. This includes research in respiration where it is believed that A2A receptors are involved in rhythm generation in the pre-Bötzinger complex. The drug is not currently approved for use in a therapeutic capacity.

See also[edit]

References[edit]

  • Mayer CA, Haxhiu MA, Martin RJ, Wilson CG (2006). "Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats". J Appl Physiol. 100 (1): 91–97. PMID 16141383. doi:10.1152/japplphysiol.00459.2005. 
  • Xie S, Shafer G, Wilson CG, Martin HB (2006). "In vitro adenosine detection with a diamond-based sensor". Dia Rel Mater. 15 (2-3): 225–228. doi:10.1016/j.diamond.2005.08.018.