Clofedanol

Chlophedianol
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Oral
ATC code	R05DB10 (WHO) ;
Identifiers
	IUPAC name 1-(2-chlorophenyl)-3-dimethylamino-; 1-phenyl-propan-1-ol;
CAS Number	791-35-5 ;
PubChem CID	2795;
DrugBank	DB04837 ;
ChemSpider	2693 ;
UNII	42C50P12AP;
KEGG	D07721 ;
ChEMBL	ChEMBL1201313 ;
CompTox Dashboard (EPA)	DTXSID4022789 ;
ECHA InfoCard	100.011.219
Chemical and physical data
Formula	C17H20ClNO
Molar mass	289.8 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccccc1C(O)(c2ccccc2)CCN(C)C;
	InChI InChI=1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3 ; Key:WRCHFMBCVFFYEQ-UHFFFAOYSA-N ;
	(what is this?) (verify)

Clofedanol (INN) or chlophedianol (BAN) is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.^[1] It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name Clofera. It has a release to market date in the beginning of the fourth quarter 2009.^[2] Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process^[3] and its safety and efficacy data are limited.

Synthesis

References

^ Template:Fr icon "Clofedanol". BIAM. 1998-07-24. Retrieved 2007-04-15.
^ "Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion". Cenrx.com. Retrieved 2009-09-27.
^ "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57" (PDF). FDA.gov. 1987-08-12.

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[1] Template:Fr icon "Clofedanol". BIAM. 1998-07-24. Retrieved 2007-04-15.

[2] "Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion". Cenrx.com. Retrieved 2009-09-27.

[3] "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57" (PDF). FDA.gov. 1987-08-12.

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[2]

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Synthesis

See also

References